EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ribosome-binding factor ArbfA PA4743Q9HV561
Ribosome-binding factor ArbfA VSAK1_10988A6D2451
Ribosome-binding factor ArbfA SPy_1719 M5005_Spy1408P659711
Ribosome-recycling factor (RRF) (Ribosome-releasing factor)frr CPF_1951Q0TPQ61
Ribosome-recycling factor (RRF) (Ribosome-releasing factor)frr YPO1047 y3133 YP_2804Q8ZH631
Ribosome-recycling factor (RRF) (Ribosome-releasing factor)frr SF0162 S0165P0A8081
Ribosome-recycling factor (RRF) (Ribosome-releasing factor)frr HPSD74_0083U4SPB71
RibulokinaseKPN_02547A6TBJ41
Ribulose-phosphate 3-epimerase (EC 5.1.3.1)Fphi_1467B0TYU61
Ribulose-phosphate 3-epimerase (EC 5.1.3.1)rpe PA0607Q9I5T11
Ribulose-phosphate 3-epimerase (EC 5.1.3.1)rpe SPy_0264Q9A1H81
Ribulose-phosphate 3-epimerase (EC 5.1.3.1)rpe1 CD630_25750Q182R31
RmuC family proteinFTN_1024A0Q6P61
RmuC family proteinOOM_1356I2B0161
RNA chaperone ProQproQ VSAK1_05305A6D6G51
RNA polymerase sigma factorVSAK1_03239A6CXE01
RNA polymerase sigma factor RpoD (Sigma-70)rpoD B195_13965M5QTQ11
RNA polymerase sigma factor RpoD (Sigma-70)alt rpoD YPO0643Q0WJ271
RNA polymerase sigma factor RpoD (Sigma-70)rpoD HPSD74_1172U4SIE01
RNA polymerase sigma factor RpoErpoE KW89_1205A0A0K2DWH41
RNA polymerase sigma factor RpoH (Heat shock regulatory protein F33.4) (RNA polymerase sigma-32 factor)rpoH fam hin htpR b3461 JW3426P0AGB31
RNA polymerase sigma factor RpoS (Sigma S) (Sigma-38)rpoS KW89_1518A0A0K2DWU81
RNA polymerase sigma factor SigArpoD sigA SPy_0782Q9A0G81
RNA polymerase sigma factor SigAsigA plaC rpoD SAOUHSC_01662P0A0J01
RNA polymerase sigma factor SigA (Sigma-43) (Sigma-A)sigA rpoD BSU25200P062241
RNA polymerase-associated protein RapA (EC 3.6.4.-) (ATP-dependent helicase HepA)rapA SSON_0065Q3Z5V21
RNA polymerase-binding transcription factor DksAdksA PA4723G3XD141
RNA-binding protein Hfqhfq Fphi_1538B0TZB11
RNA-binding protein Hfqhfq PA4944Q9HUM01
RNA-binding protein Hfqhfq CD630_19740Q187T21
RNA-binding protein Hfqhfq OOM_1325I2AZZ01
RNA-binding protein Hfqhfq FTT_0630Q5NH411
RNA-binding protein YhbYyhbY b3180 JW3147P0AGK41
Rna-binding protein, yhby familyCD630_11650Q18B261
RNase adapter protein RapZrapZ YPO3586 y0158 YP_3840Q8ZB411
RNase I (EC 3.1.27.6)rna STM0617Q8ZR161
RND efflux system outer membrane lipoproteinNSU_4717G6EK461
RND efflux system outer membrane lipoproteinNSU_2605G6EE341
RND efflux system, outer membrane lipoprotein,NodTNSU_1588G6EB671
RND efflux transporterPP_1517Q88MQ31
RND efflux transporterPP_5173Q88CK71
Rod shape-determining protein MreBB195_04911M5QYM91
Rod shape-determining protein MreBmreB BSU28030Q014651
Rod shape-determining protein MreBenvB YPO3665Q7CL651
Rod shape-determining protein MreBVSAK1_08271A6D0371
Rod shape-determining protein MreBmreB2 CD630_11450Q18B051
ROK family proteinFTN_0617A0Q5J61
ROK family proteincscK FTN_0646A0Q5M41
ROK family proteinVSAK1_22089A6D6M61
Rough colony protein BSC1083_1233G4A8T11
RoxRroxR PA4493Q9HVS81
RsbR proteinRsbRQ8Y8K91
RsbT co-antagonist protein RsbRA (Stressosome protein RsbRA)rsbRA rsbR ycxR BSU04670P424091
RsbT co-antagonist protein RsbRB (Stressosome protein RsbRB)rsbRB ykoB BSU13200O348601
Rubredoxin-NAD(+) reductase (RdxR) (EC 1.18.1.1)alkT PA5349Q9HTK91
Rubredoxin/flavodoxin/oxidoreductaseCPC_1265B1BEV41
RubrerythrinCPR_2638C6UAS61
Rubrerythrinrbr FSU_0915C9RLG21
Rz lysis proteinenpP SCH_0350Q57SQ51
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284)Fphi_0427B0U0161
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284)adhC FTN_0409A0Q4Z71
S-(Hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284)B195_06095M5R1881
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284)VSAK1_11845A6D2U51
S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase alpha chain]speH PA4773Q9HV351
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK NMB1799Q9JY091
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK spr0671Q8DQH01
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK YPO0931 y3314 YP_3512Q8ZHG71
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK SF2933 S3137P0A8201
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK Rv1392 MTCY21B4.09P9WGV11
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK KPR_4645R4YFG01
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK metX b2942 JW2909P0A8171
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK SSON_3096Q3YXS91
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK SPy_1359 M5005_Spy1108Q99Z771
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK CD630_01300Q18CL71
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK FSU_0038C9RNB71
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK SCH_3030Q57K261
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK SAOUHSC_01909Q2G1W41
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK FTT_0149cQ5NIC71
S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 2.4.99.17) (Queuosine biosynthesis protein QueA)queA SPy_1400 M5005_Spy1140Q99Z491
S-formylglutathione hydrolase (EC 3.1.2.12)VSAK1_11850A6D2U61
S-layer proteinslpAQ9AEM31
S-layer proteinCDIF1296T_02929A0A125V9601
S-methyl-5-thioadenosine phosphorylase (EC 2.4.2.28)Fphi_1715B0U0B01
S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS)luxS YPO3300 y0888 YP_0386Q8ZBU31
S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS)luxS SSON_2831Q3YYH11
S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS)luxS SPy_1642 M5005_Spy1349P0C0C81
S1 RNA binding domain proteinSAOUHSC_02297Q2FWJ51
S41 family peptidaseB195_20148M5QCZ51
SapA-like proteinsapA SCH_0307Q57SU81
Scaffolding protein for murein-synthesising holoenzymemipA KPN_01194A6T7Q61
Scaffolding protein for murein-synthesizing holoenzymemipA SCH_1298Q57Q071
Sco1-related proteinVSAK1_19069A6CXZ11
SCP-2 sterol transfer family proteinKW89_379A0A0K2DU561
Sec translocon accessory complex subunit YajCyajC b0407 JW0397P0ADZ71
Sec-independent protein translocase protein TatAtatA Rv2094c MTCY49.34cP9WGA11
Sec-independent protein translocase protein TatAtatA PA5068Q9HUB51
Sec-independent protein translocase protein TatAtatA mttA1 yigT b3836 JW3813P694281
Sec-independent protein translocase protein TatCtatC VSAK1_13195A6D2C81
Sec-independent protein translocase protein TatEtatE ybeC b0627 JW0622P0A8431
Secreted chorismate mutase (*MtCM) (CM) (EC 5.4.99.5)pheA2 y2828 YP_1243 YPO1353Q7CHH51
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