EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Type 4 prepilin-like proteins leader peptide-processing enzyme (EC 2.1.1.-) (EC 3.4.23.43)OOM_1374I2B0311
Type I restriction modification DNA specificity domain proteinKW89_2484A0A0K2DZK81
Type I restriction-modification system, M subunit (EC 2.1.1.-)SAOUHSC_01933Q2FXD01
Type I secretion membrane fusion, HlyD family proteinHPSD74_1471U4SHZ81
Type I secretion system ATPasehlyB1A0A075FK961
Type I secretion system ATPase, PrtDVSAK1_06210A6CZN21
Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase)coaX Fphi_1333B0TXZ71
Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase)coaX FTN_1355A0Q7L51
Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase)coaX FTN_1603A0Q8981
Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase)coaX CD196_3346A0A0H3NC161
Type III pantothenate kinase 2 (EC 2.7.1.33) (PanK-III 2) (Pantothenic acid kinase 2)coaX2 FTT_1392Q5NF551
Type III secretion protein, FHIPEP familyMXAN_5643Q1D0P11
Type III secretion system effector protein CeseC ETAE_0870D0ZDL01
Type III secretion system effector protein D (Fragment)eseDQ4ACE61
Type IV pili associated proteinFTT_1159cQ5NFR61
Type IV pili ATPasepilB FTN_1115A0Q6Y61
Type IV pili fiber building block proteinFTT_0888cQ5NGF71
Type IV pili fiber building block proteinFTT_0890cQ5NGF51
Type IV pili glycosylation proteinFTT_1158cQ5NFR71
Type IV pili lipoproteinFTT_1057cQ5NG041
Type IV pili lipoproteinFTT_1157cQ5NFR81
Type IV pili nucleotide-binding proteinFphi_0996B0TWW21
Type IV pili polytopic inner membrane proteinpilC FTN_1116A0Q6Y71
Type IV pili polytopic inner membrane proteinpilC FTT_1134Q5NFT61
Type IV pili, pilus assembly proteinOOM_0611I2AY741
Type IV pilin multimeric outer membrane proteinpilQ FTT_1156cQ5NFR91
Type IV pilus assembly protein PilXNGK_0626B4RKG61
Type IV pilus biogenesis and competence protein PilQpilQ NMBH4476_1758 NMH_1547Q9ZHF31
Type IV pilus biogenesis protein PilCpilC KW89_308A0A0K2DTG81
Type IV pilus biogenesis/stability protein PilWpilF NMH_1737E6MZ651
Type IV pilus biogenesis/stability protein PilWpilF HPSD74_1951U4SC021
Type IV secretion system protein IcmBicmB KW89_1829A0A0K2DY631
Type IV secretion system protein IcmGicmG KW89_2388A0A0K2DZQ21
Type IV secretion system protein IcmLicmL KU39_1295 KW89_1825A0A095BKQ01
Type IV secretion system protein VirB9virB9 NSU_1176G6EA051
Type IV secretion system protein VirB9KW89_126A0A0K2DSY31
Type-1 fimbrial protein, C chain (Type-1C pilin)pilC focA c1239P626061
Tyrosine recombinase XerD-likeSPCG_1850B2ISX51
Tyrosine recombinase XerD-likeSPy_0365 M5005_Spy0307Q9A1B31
Tyrosine recombinase XerSxerS spr1046Q7ZAK71
Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS FTN_0992A0Q6L51
Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS YPO2369 y1966 YP_2155Q8ZE201
Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS SSON_1519Q3Z1Z31
Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS SPy_0096 M5005_Spy0081Q9A1U31
Tyrosine--tRNA ligase 1 (EC 6.1.1.1) (Tyrosyl-tRNA synthetase 1) (TyrRS 1)tyrS1 BSU29670P223261
Tyrosine--tRNA ligase 2 (EC 6.1.1.1) (Tyrosyl-tRNA synthetase 2) (TyrRS 2)tyrS2 PA0668Q9I5Q31
Tyrosine-protein kinase etk (EC 2.7.10.-)etk HPSD74_0333U4SLF51
Tyrosine-protein kinase wzc (EC 2.7.10.-)wzc b2060 JW2045P763871
Ubiquinol oxidase subunit 2cyoA ACINWC136_2569K9C6411
Ubiquinol oxidase subunit 2VSAK1_06665A6D1U11
Ubiquinol oxidase subunit 2qoxA Smlt1360B2FUA01
Ubiquinol oxidase subunit 2cyoA SCH_0485Q57SC01
Ubiquinol oxidase subunit 2cyoA FTT_0281Q5NI111
Ubiquinol oxidase subunit I, cyanide insensitivecioA PP_4651Q88E171
Ubiquinol--cytochrome C reductase, cytochrome C1 subunitB195_12096M5QHW31
Ubiquinol-cytochrome c reductase, iron-sulfur subunit (Fragment)VSAK1_04830A6D9R81
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC 2.1.1.163) (EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase) (Demethylmenaquinone methyltransferase)ubiE B195_02553M5QNZ31
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC 2.1.1.163) (EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase) (Demethylmenaquinone methyltransferase)ubiE PP_5011Q88D171
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC 2.1.1.163) (EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase) (Demethylmenaquinone methyltransferase)ubiE VSAK1_13170A6D2C31
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC 2.1.1.163) (EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase) (Demethylmenaquinone methyltransferase)ubiE OOM_0442I2AXS81
UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosamine diphosphatase)lpxH FTT_0436cQ5NHL61
UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase)lpxC Fphi_0658B0TVX11
UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase)lpxC envA PA4406P472051
UDP-3-O-acylglucosamine N-acyltransferase (EC 2.3.1.-)lpxD Fphi_0632B0U1351
UDP-3-O-acylglucosamine N-acyltransferase (EC 2.3.1.-)lpxD FTN_1480A0Q7Y21
UDP-3-O-acylglucosamine N-acyltransferase (EC 2.3.1.-)lpxD VSAK1_11730A6D8P21
UDP-3-O-acylglucosamine N-acyltransferase (EC 2.3.1.-)lpxD OOM_0744I2AYI61
UDP-3-O-acylglucosamine N-acyltransferase 2 (EC 2.3.1.-)lpxD2 lpxD1 FTT_1571cQ5NEP91
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.87) (UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase) (UDP-Ara4O aminotransferase) (UDP-4-amino-4-deoxy-L-arabinose aminotransferase)arnB PA3552Q9HY651
UDP-GlcNAc/Glc 4-epimerase (EC 5.1.3.2)gne Cj1131cQ0P9C31
UDP-glucose 4-epimerase (EC 5.1.3.2)wbtC FTT_1462cQ5NEZ31
UDP-glucose 6-dehydrogenase (EC 1.1.1.22)ugd SP70585_0425C1CBE01
UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22)hasB SPy_2201 M5005_Spy1852P0C0F51
UDP-glucose dehydrogenase (EC 1.1.1.22)ugd spr0139Q8DRG51
UDP-N-acetyl-D-mannosaminuronic acid dehydrogenaserffD spr0961Q8DPX41
UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.3.1.98) (UDP-N-acetylmuramate dehydrogenase)murB SPy_1101 M5005_Spy0825Q99ZS91
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT)murA VSAK1_02004A6D4E01
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT)murA SAOUHSC_02337Q2FWF41
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (EC 2.5.1.7) (Enoylpyruvate transferase 1) (UDP-N-acetylglucosamine enolpyruvyl transferase 1) (EPT 1)murA1 murA MW2024P840591
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (EC 2.5.1.7) (Enoylpyruvate transferase 1) (UDP-N-acetylglucosamine enolpyruvyl transferase 1) (EPT 1)murA1 murA SPy_0763 M5005_Spy0584P654581
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (EC 2.5.1.7) (Enoylpyruvate transferase 2) (UDP-N-acetylglucosamine enolpyruvyl transferase 2) (EPT 2)murA2 murZ SPy_1358 M5005_Spy1107Q99Z781
UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)mnaA AC3_2792B1BRT01
UDP-N-acetylglucosamine 4,6-dehydratase (inverting) (EC 4.2.1.115) (Pseudaminic acid biosynthesis protein B) (UDP-GlcNAc-inverting 4,6-dehydratase)pseB Cj1293Q0P8W41
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)murG PA4412Q9HW011
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)murG SPy_1524 M5005_Spy1252P654831
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)murG FSU_0991C9RM161
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)murG SAOUHSC_01424Q2FYL51
UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase)murC SPy_0345 M5005_Spy0290Q9A1C71
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase (EC 6.3.2.7) (L-lysine-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:L-Lys ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)murE SPy_0388 M5005_Spy0325Q9A1961
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme)murF SPy_1420Q99Z351
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)murD SPN23F06220B8ZMZ61
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)murD SPy_1525 M5005_Spy1253P0C0D81
UDP-N-acetylmuramyl tripeptide synthetase MurC homologCPR_1206Q0STM91
UDP-N-acetylmuramyl tripeptide synthetase, putativeSAOUHSC_02107Q2FWZ91
Uncharacterised proteinERS852446_02894 pBeta2_00059G5DSA81
Uncharacterised proteinSAMEA3374989_04390A0A170Y0C71
Uncharacterised proteinSAMEA3375004_00276A0A160YKK21
Uncharacterised proteinBN1095_1130002 BN1096_1120002 BN1097_820003 SAMEA3375004_04010 SAMEA3375059_04333A0A031W9A41
Uncharacterized ABC transporter ATP-binding protein YejFyejF b2180 JW2168P339161
Uncharacterized ABC transporter solute-binding protein YclQyclQ BSU03830P944211
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