EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ferrichrome receptor FiuAfiuA PA0470Q9I6483
Ferrichrome-iron receptor (Ferric hydroxamate receptor) (Ferric hydroxamate uptake)fhuA tonA b0150 JW0146P069713
Fibronectin type III domain proteinMXAN_4796Q1D3153
Fimbrial chaperone (Fimbrial chaperone protein FimC)focC focC_2 A5958_24190 ACN77_28800 ACN81_11765 AMK83_09775 BHF46_11395 BK373_20355 ERS085379_04793 ERS085386_04307 GJ11_10300 JD73_26070 MJ49_24320 UN86_18260 UN91_25940A0A066RDY23
Flagellar basal body rod protein FlgBflgB BE932_29575 SY51_05930A0A061YDX03
Flagellar basal-body rod protein FlgCflgC A4T40_09135 BK334_17180 ECONIH1_06605 MS6198_12070A0A0A1A2V53
Flagellar basal-body rod protein FlgG (Distal rod protein)flgG PP_4385Q88ER83
Flagellar basal-body rod protein FlgG (Distal rod protein)flgG ECED1_1222B7MTK93
Flagellar biosynthesis protein FlgL (Flagellar hook protein FlgL) (Flagellar hook-associated protein 3) (Flagellar hook-filament junction protein FlgL)flgL BK248_11950 BK373_19855 BMT49_08335 ERS085366_02278 MJ49_00740 SY51_05980A0A061YDX83
Flagellar hook protein FlgEflgE PP_4388Q88ER53
Flagellar hook protein FlgEflgE BE932_29590 SY51_05945A0A066SNC53
Flagellar hook-associated protein 1 (HAP1)flgK BE932_29620 SY51_05975A0A066SNK83
Flagellar hook-associated protein 2 (HAP2) (Flagellar cap protein)fliD PP_4376Q88ES73
Flagellar hook-associated protein 2 (HAP2) (Flagellar cap protein)fliD Smlt2303B2FQU43
Flagellar hook-associated protein FlgKflgK PP_4381Q88ES23
Flagellar hook-associated protein FlgLflgL PP_4380Q88ES33
Flagellar P-ring protein (Basal body P-ring protein)flgI PA1084Q9I4P53
FlagellinfliC flaF hag b1923 JW1908P049493
Flagellinhag BSU35360P029683
FlagellinfliC PP_4378Q88ES53
FlagellinfliCA0A0F3SVQ73
FlagellinfliC fliCH28A0A0F3UNF43
Flagellin AflaA Cj1339cP569633
Flagellin BflaB Cj1338cP569643
Flavin-containing monooxygenasephzS PA4217Q9HWG93
FlgMflgM PA3351Q9HYP53
Formate C-acetyltransferase (Formate acetyltransferase 1) (Pyruvate formate-lyase) (EC 2.3.1.54)pflB ACU90_17935 BE957_19825 BK334_18015 BK383_04155 BMT97_10320 BUE82_15450 ECONIH1_05765 MS6198_10460A0A0A1A6F53
Formate dehydrogenase-O major subunit (Formate dehydrogenase-O, major subunit)fdoG PGD_03102 SK85_04224A0A024L6U03
Formate dehydrogenase-O, large subunit (EC 1.2.1.2)fdoG ECED1_4597B7N2N73
Fumarate hydratase class I (EC 4.2.1.2)BE932_03460 SY51_09005A0A066SZL63
Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase)fumC Cj1364cO692943
Fumarate reductase flavoprotein subunit (EC 1.3.5.4)frdA BW690_00480 PGD_03338A0A024L7L93
G/U mismatch-specific DNA glycosylase (EC 3.2.2.28) (Double-strand-specific uracil glycosylase) (Mismatch-specific uracil DNA-glycosylase) (MUG)mug EcSMS35_3362B1LF613
GalU regulator GalF (UTP--glucose-1-phosphate uridylyltransferase)BE932_07670 BET08_08595 SY51_11845A0A066T4J13
Gamma-glutamyltranspeptidaseggt FTN_1159A0Q7303
Glucohydrolase (Trehalose-6-phosphate hydrolase) (EC 3.2.1.93)BE932_21720 SY51_24410A0A061KF913
Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24)rmlA BE932_07650 BET08_08610 SY51_11830A0A066SZW03
Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)zwf PA3183O682823
Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)zwf BW690_20570 PGD_01378A0A024L2H13
Glutamate / aspartate ABC transporter-periplasmic binding protein (EC 3.6.3.21)gltI PP_1071Q88NY23
Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK)proB A4T40_04695 BK248_22745 BK334_06595 ECONIH1_01380 MS6198_02820A0A0A1A1I13
Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)gltX HMPREF3040_04863A0A0B5HIL63
Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT)hemL PA3977P482473
Glutaminase-asparaginase (EC 3.5.1.38) (L-ASNase/L-GLNase) (L-asparagine/L-glutamine amidohydrolase)ansB PP_2453Q88K393
Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I beta) (GSI beta)glnA Z5406 ECs4792P0A9C73
Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7)gatA PA4483Q9HVT83
Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7)gatA spr0394Q8DR103
GlutaredoxinPA3533Q9HY773
Glutaredoxin (Glutaredoxin 2) (Glutaredoxin, GrxB family) (Glutaredoxin-2)grxB A4T40_09085 BK334_17230 ECONIH1_06555 MS6198_11970A0A0A1A2U93
Glutaredoxin 4 (Grx4) (Monothiol glutaredoxin)grxD ydhD Z2676 ECs2363P0AC713
Glutaryl-CoA dehydrogenasegcdH PA0447Q9I6713
Glutathione reductase (EC 1.8.1.7) (Glutathione-disulfide reductase)BE932_16480 SY51_19960A0A066T5513
Glutathione synthetase (EC 6.3.2.3) (GSH synthetase) (GSH-S) (GSHase) (Glutathione synthase)gshB BE932_12850 SM09_03106 SY51_16550A0A0J3VSS83
Glutathione transferase GstABET08_08265 BK337_09385 BUE81_02335A0A0A6RYT33
Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.-)LMRG_01789A0A0H3GFI93
Glyceraldehyde-3-phosphate dehydrogenase 1 (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase)gapA gap BSU33940P091243
Glycerol kinase 2 (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 2) (Glycerokinase 2) (GK 2)glpK2 glpK glpK1 PA3582Q513903
Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3)glpD BE932_16085 SY51_19575A0A066SN123
Glycine cleavage system H protein 1gcvH1 PA2446Q9I1363
Glycine cleavage system H protein 2gcvH2 PA5214Q9HTX63
Glycine-glutamate dipeptide porin (EC 3.4.21.-)opdP PP_0883Q88PG73
Glycosyl hydrolase family 3bglX FTN_1474A0Q7X63
Group A colicin translocation tolQ proteintolQ FTN_0352A0Q4U33
GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)folE EcE24377A_2449A7ZNX63
GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)ribA EcE24377A_1479A7ZL973
GTPase Der (GTP-binding protein EngA)der BV389_04925 UN91_26610A0A0F3U1Y33
GTPase Eraera_3 era A4T40_18115 BK334_05090 ECONIH1_14960 MS6198_28980A0A0A1AB573
Hemolysin A (EC 4.6.1.1)hlyA UTI89_C4926Q1R2T53
Histidine acid phosphataseFTN_0022A0Q3W83
Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)hutH MXAN_3465Q1D6R13
Histidine biosynthesis bifunctional protein HisB [Includes: Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19); Histidinol-phosphatase (EC 3.1.3.15)]hisB BE932_07570 SY51_11750A0A066T4D73
Histidine biosynthesis bifunctional protein HisB [Includes: Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19); Histidinol-phosphatase (EC 3.1.3.15)]hisB BHS87_11665 PGD_01194A0A024L0G43
Histidine-specific outer membrane porin D (EC 3.4.21.-)opdC PP_0799Q88PP93
Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12)ruvA EcHS_A1954A8A1613
Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS)acpS BV389_12490 UN91_26360A0A0F3UV863
Homogentisate 1,2-dioxygenase (HGDO) (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)hmgA MXAN_2787Q1D8L93
Homolog of E. coli rod shape-determining proteinmreB Cj0276Q0PBM93
Homoserine dehydrogenase (HDH) (EC 1.1.1.3)hom PA3736P293653
HTH-type transcriptional regulator ArgPargP iciA EcE24377A_3243A7ZR243
HTH-type transcriptional repressor FabRyijC fabR AC789_1c43590A0A0E1LIN13
Immunomodulating metalloprotease (EC 3.4.24.-) (IMPa)impA PA0572Q9I5W43
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)ppa PA4031Q9HWZ63
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)ppa Z5837 ECs5204P0A7B03
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)ppa BHS81_25280 JD73_14775A0A085P7173
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205)guaB A4T50_06025 BE932_10335 BE963_28300 BK375_00755 BK383_22720 BMT94_06480 BUE82_06005 ERS085406_03446 GJ11_16380 SM09_02668 SY51_14410 UC41_13120 WM48_13430E2QPX13
IntegraseA4T50_21330 BE932_29905 BV389_20690 SY51_06255E2QKM03
Integration host factor subunit alpha (IHF-alpha)ihfA himA EcE24377A_1931A7ZMI03
Iron(3+)-hydroxamate-binding protein YxeB (Ferric hydroxamate uptake protein YxeB) (Iron(III)-hydroxamate-binding protein YxeB)yxeB BSU39610 HS74BRP549413
Iron(III) dicitrate transport protein (FecA)HP_0686O253953
Iron-regulated outer membrane protein FrpBfrpB NMB1988Q9JXL33
Iron-sulfur cluster carrier proteinUMNK88_2656A0A0E0U0C63
Iron-uptake system-binding proteinfeuA BSU01630P404093
Isochorismate synthase MenF (EC 5.4.4.2) (Isochorismate mutase)menF ACN002_2324 ACN77_21785 AM270_05965 AML07_04270 APZ14_21820 AUS26_02320 BMT53_24690 BMT61_11615 ERS085374_00303 ERS139235_00464 ERS150876_02677 PU06_13010 RG28_10490 WQ89_02490A0A086U8E83
Isocitrate dehydrogenase (EC 1.1.1.42)icd Cj0531Q0PAY53
Ketol-acid reductoisomeraseilvC FTN_1040A0Q6R23
Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I)ilvC Cj0632Q9PHN53
Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I)ilvC PP_4678Q88DZ03
L-arginine ABC transporter-periplasmic binding subunit (EC 3.6.3.21)artJ PP_0282Q88R523
L-asparaginase 2 (L-asparaginase II) (EC 3.5.1.1)ansB ansB_1 A4T40_20190 BE932_12915 BIQ85_16465 BK334_10880 BK383_12685 BMT97_15870 BUE82_03310 ECONIH1_17035 GJ11_19205 MS6198_33080 SK85_03219 SY51_16615A0A023LIJ53
L-glyceraldehyde 3-phosphate reductaseBK400_12380 WR15_10595A0A0B1F2D63
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