EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Phosphoglucomutasepgm CE10_0678A0A0E0V3383
Phosphoglucosamine mutase (EC 5.4.2.10)glmM PA4749Q9HV503
Phosphoglycerate kinase (EC 2.7.2.3)pgk PA0552Q9I5Y43
Phospholipase (Phospholipase A) (EC 3.1.1.32) (EC 3.1.1.4)A4T50_13445 APU18_23080 BE932_18380 SY51_21735 WM48_21070E2QHZ43
Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase)purD ECED1_4712B7N2K73
Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT)purL BE932_10570 SY51_14640A0A066T7J43
Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT)serC ECED1_0934B7MS223
Pneumococcal surface protein ApspA SPCG_0120B2IRK13
Polar amino acid uptake transporterFTN_0191A0Q4D63
Polyamine-transporting ATPase (EC 3.6.3.31)PA0603Q9I5T53
Polyphosphate kinase (EC 2.7.4.1) (ATP-polyphosphate phosphotransferase) (Polyphosphoric acid kinase)ppk PA5242Q9S6463
Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase)pnp E2348C_3445B7UJ593
PorinoprB-I PP_1019Q88P343
PorinoprB-III PP_3570Q88GZ53
PorinrpfN Smlt2559B2FSS73
Positive alginate biosynthesis regulatory proteinalgR PA5261P262753
Potassium-transporting ATPase ATP-binding subunit (EC 3.6.3.12) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium-binding and translocating subunit B) (Potassium-translocating ATPase B chain)kdpB FTN_1717A0Q8K93
Potassium-transporting ATPase ATP-binding subunit (EC 3.6.3.12) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium-binding and translocating subunit B) (Potassium-translocating ATPase B chain)kdpB PA1634P576983
Potential aminotransferase (EC 2.6.1.1)aspC spr1808Q8DNC73
Predicted type I restriction-modification enzyme M subunitE2348C_4610B7UQU33
Predicted type I restriction-modification enzyme S subunitE2348C_4609B7UQU23
Primosomal replication protein NBE932_25960 SY51_02435A0A061KQ463
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (EC 3.5.1.n3)arnD A4T40_16615 BK334_03330 ECONIH1_13180 MS6198_25910A0A0A1AA633
Probable AGCS sodium/alanine/glycine symporterPA2252Q9I1L73
Probable aldehyde dehydrogenasePA4022Q9HX053
Probable ATP-binding component of ABC dipeptide transporterPA4506Q9HVR53
Probable ATP-binding component of ABC transporterPA4505Q9HVR63
Probable ATP-binding component of ABC transporterPA4595Q9HVJ13
Probable bacteriophage proteinPA0638Q9I5S83
Probable chemotaxis proteinPA3349Q9HYP73
Probable chemotaxis transducerPA1608Q9I3B33
Probable chemotaxis transducerPA4633Q9HVF83
Probable ClpA/B protease ATP binding subunitPA0459Q9I6593
Probable cold-shock proteinPA0456Q9I6623
Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase)pepA BX23_11600A0A028E6T33
Probable efflux pump membrane transporter TtgBttgB PP_1385Q88N313
Probable efflux pump outer membrane protein TtgCttgC PP_1384Q88N323
Probable efflux pump periplasmic linker TtgAttgA PP_1386Q88N303
Probable enoyl-CoA hydratase/isomerasePA0745Q9I5I43
Probable glyceraldehyde-3-phosphate dehydrogenasePA2323Q9I1F53
Probable GTP-binding protein EngBengB EcE24377A_4383A7ZU663
Probable L,D-transpeptidase YbiS (EC 2.-.-.-)ybiS Z1041 ECs0896P0AAY03
Probable L-asparaginase (L-ASNase) (EC 3.5.1.1) (L-asparagine amidohydrolase)ansA asn HP_0723O254243
Probable lipoprotein YiaDyiaD b3552 JW5657P376653
Probable outer membrane proteinopmD PA4208Q9HWH33
Probable outer membrane proteinPA1048Q9I4S63
Probable oxidoreductasePA1833Q9I2R23
Probable phospholipid import ATP-binding protein MlaF (EC 3.6.3.-)mlaF Z4558 ECs4074P633883
Probable purine-binding chemotaxis proteinPA1464G3XD723
Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion proteinPA4374Q9HW283
Probable Resistance-Nodulation-Cell Division (RND) efflux transportermexI PA4207Q9HWH43
Probable septum site-determining protein MinCminC BX23_12090A0A028E6333
Probable siderophore-binding lipoprotein YfiYyfiY BSU08440O315673
Probable thioredoxinPA0953Q9I5053
Probable TonB-dependent receptorPA5505Q9HT683
Protease 7 (EC 3.4.23.49)ompT ECDEC1D_0931H4J4S03
Protease B (EC 3.4.-.-)prtB MXAN_2791Q1D8L53
Protease HtpX (EC 3.4.24.-) (Heat shock protein HtpX)htpX PP_1871Q88LQ83
Protein CyaEtolC Smlt3928B2FTS53
Protein TolBtolB FTN_0355A0Q4U63
Protein TolBtolB Cj0112Q9PJ143
Protein TolBtolB PP_1222P0A1733
Protein TolBtolB HP_1126O257513
Protein TolRtolR PA0970P505993
Protein TonBAC789_1c05620 ACN002_0554 APT94_07960 APU18_12400 BET08_30795 BK373_12420 BMT94_24345 BN17_22271 HMPREF3040_04526 SM09_05063 SY51_06410 WM48_06000E2QKQ23
Protein translocase subunit SecAsecA spr1544Q8DNT83
Protein translocase subunit SecAsecA E2348C_0103B7UIE83
Protein translocase subunit SecDFsecDF BSU27650O320473
Protein transporter, outer bacterial membrane secretin (Secretin) familyMXAN_3106Q1D7R43
Protein YebFyebF b1847 JW1836P332193
Protein-disulfide isomeraseFTN_0771A0Q5Z73
Protein-disulfide isomeraseFTN_0597A0Q5H73
Protein-export membrane protein SecG (P12) (Preprotein translocase band 1 subunit)secG Z4537 ECs4054P0AGA13
Protein-export protein SecBsecB PA5128Q9HU563
Protoporphyrinogen IX dehydrogenase [menaquinone] (Protoporphyrinogen IX oxidase HemG) (Protoporphyrinogen oxidase) (EC 1.3.3.4) (EC 1.3.5.3)hemG AA102_11500 ACN77_18125 ACN81_23910 ACU90_13925 AML07_08265 APZ14_07770 AUS26_26115 BE957_02840 BHF46_22510 BHS81_23030 BK400_20800 BMT53_14410 BMT61_12715 BW690_25260 ERS085374_03145 ERS150876_04184 FORC28_5937 GJ11_24465 GJ12_23730 HW42_00740 PGD_00121 PU06_16905 RG28_24565 SK85_04176A0A024L7L13
Protoporphyrinogen oxidase (EC 1.3.3.4)hemG EcSMS35_4231B1LM363
Pseudouridine synthase (EC 5.4.99.-)rsuA CE10_2557A0A0E0V7W23
Pseudouridine synthase (EC 5.4.99.-)rluD A5958_17240 AA102_04920 ACN77_02865 ACN81_10225 ACU90_01895 AM270_24195 AMK83_27920 BE957_09685 BMT61_22580 ERS085374_05138 GJ12_17190 PU06_25505 UN86_25225 WQ89_15875A0A066RC263
PTS system glucose-specific EIICBA component (EC 2.7.1.199) (EII-Glc/EIII-Glc) (EIICBA-Glc) (EIICBA-Glc 1) [Includes: Glucose permease IIC component (PTS system glucose-specific EIIC component); Glucose-specific phosphotransferase enzyme IIB component (PTS system glucose-specific EIIB component); Glucose-specific phosphotransferase enzyme IIA component (PTS system glucose-specific EIIA component)]ptsG crr ptsX BSU13890P201663
Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1)deoD EcE24377A_4983A7ZVS73
Putative 2',3'-cyclic-nucleotide 2'-phosphodiesteraseMXAN_6266Q1CYX83
Putative 28 kDa outer membrane proteinMXAN_7203Q1CWA73
Putative ACR family proteinSmlt3869B2FT313
Putative acyl-CoA thioester hydrolase YbhC (EC 3.1.2.-)ybhC b0772 JW0755P461303
Putative alkaline phosphataseMXAN_1389Q1DCH73
Putative alkyl hydroperoxide reductase subunit c (EC 1.11.1.15)ahpC Smlt0841B2FPY73
Putative amino-acid transporter periplasmic solute-binding proteincjaA Cj0982cQ0P9S03
Putative autotransporter subtilisin-like proteasesphB Smlt3524B2FPV53
Putative cell division proteinPP_5090Q88CU03
Putative cytochrome C551 peroxidase (EC 1.11.1.5)Cj0358Q0PBF13
Putative endonuclease P1 (EC 3.1.30.1)Smlt3806B2FSF83
Putative fibronectin domain-containing lipoproteinCj1279cQ0P8X73
Putative fimbria adhesin proteinSmlt0709B2FNJ33
Putative glycosyltransferaseSP70585_0422C1CBD73
Putative GMC oxidoreductase subunitCj0415Q0PB953
Putative intercellular spreading VacJ lipoproteinSmlt4675B2FP873
Putative iron transporterSmlt2858B2FHT93
Putative iron-uptake ABC transport system,periplasmic iron-binding proteincfbpA Cj0175cQ0PBW43
Putative lipoproteinMXAN_5684Q1D0K13
Putative lipoproteinMXAN_7333Q1CVX73
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