EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)VSAK1_07049A6D5572
60 kDa chaperonin (Fragment)groEL VSAK1_11253A6D8X52
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL FTN_1538A0Q8382
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL ACICU_02908B2HXB62
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL spr1722P0A3362
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL ACL_1247A9NHL62
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL mopA STM4330P0A1D32
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL PP_1361Q88N552
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL SPy_2070 M5005_Spy1761P698832
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL SSON_4326Q3YUJ72
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL cpn60 groEL mopA BP3495P482102
60 kDa chaperonin (GroEL protein) (Protein Cpn60) (Stress protein H5)groL groEL mopA BSU06030P285982
ABC periplasmic phosphonate binding protein, phnDVSAK1_20094A6CWU92
ABC transport protein, periplasmic componentBP2616Q7VVN12
ABC transporter ATP-binding protein (ABC transporter ATPase)uup BE932_28970 ERS085406_01227 SY51_05340A0A061YMQ12
ABC transporter ATP-binding protein (Energy-dependent translational throttle protein EttA) (Putative ABC transporter ATP-binding protein YjjK)yjjK A4T50_17670 APU18_05560 BE932_22945 BMT49_01245 ERS085406_00382 GJ11_27565 SY51_25270 WM48_25025E2QLF22
ABC transporter ATP-binding protein-aspartate/glutamate transportABC-NDB spr1314Q8DP772
ABC transporter ATP-binding protein-glutamineglnQ spr0408Q8DR012
ABC transporter ATP-binding protein-multiple sugar transportmsmK spr1437Q8DP032
ABC transporter ATP-binding protein-ribose/galactose transportABC-NBD spr0748Q8DQC12
ABC transporter solute binding protein-sugar transportABC-SBP spr0083Q8DRJ62
ABC transporter substrate-binding protein (Hemin ABC transporter substrate-binding protein) (Hemin-binding periplasmic protein HmuT)hmuT BK334_07070 ECONIH1_20425 MS6198_40120A0A0A1AAR52
ABC transporter substrate-binding protein-branched chain amino acid transportlivJ spr0659Q8DQI12
ABC transporter substrate-binding protein-glutamine transportglnH spr1353Q8DP502
ABC transporter substrate-binding protein-glutamine-binding proteinglnH spr1251Q8DPB72
ABC transporter, ATP-binding proteinyhbG FTN_0902A0Q6C52
ABC transporter, ATP-binding proteinFTN_0141A0Q4872
ABC transporter, membrane spanning protein (Ribose)VSAK1_19369A6CWF42
ABC transporter, periplasmic solute-binding proteinNMB0041Q9K1P02
ABC transporter, periplasmic substrate-binding proteinVSAK1_23714A6CWE92
ABC transporter, periplasmic substrate-binding proteinVSAK1_01587A6D2K32
ABC transporter, substrate-binding protein, family 3ACINWC136_1675K9CGX72
ABC-transport protein, solute-binding componentBP2692Q7VVH32
ABC-type Fe3+ transport system, periplasmic componentVSAK1_17762A6CVB32
ABC-type Fe3+-hydroxamate transport system, periplasmic componentVSAK1_20944A6CYG62
ABC-type oligopeptide transport system, periplasmic componentVSAK1_03344A6CXG12
ABC-type phosphate transport system, periplasmic componentVSAK1_17967A6CVF42
ABC-type phosphate transport system, periplasmic componentVSAK1_14480A6D4T12
ABC-type sugar transport system, periplasmic componentVSAK1_22804A6CVW72
ABC-type sugar transport system, periplasmic componentVSAK1_10388A6D0T52
ABC-type sugar transport system, periplasmic componentVSAK1_07094A6D4W62
ABC-type sugar transport system, periplasmic componentVSAK1_02374A6D9762
ABC-type transport system, ATPase componentACL_1103A9NH832
ABC-type transport system, ligand-binding componentACL_0661A9NFZ72
ABC-type transport system, substrat-binding componentACL_1223A9NHJ22
ABC-type transport system, substrate-binding componentACL_1410A9NE412
Acetate kinase (EC 2.7.2.1) (Acetokinase)ackA ACL_0496A9NFI42
Acetate kinase (EC 2.7.2.1) (Acetokinase)ackA VSAK1_03379A6CXG82
Acetate kinase 1 (EC 2.7.2.1) (Acetokinase 1)ackA1 lmo1581Q8Y6V02
Acetolactate synthase (EC 2.2.1.6)VSAK1_24540A6D4052
Acetolactate synthase (EC 2.2.1.6) (ALS) (Acetohydroxy-acid synthase)alsS BSU36010Q047892
Acetyl-CoA acetyltransferase (EC 2.3.1.9)atoB thlA A9R57_04050 BHS87_12725 BJJ90_08140 ERS085365_00126 ERS085416_00548 ERS139211_00184 ERS150873_00466 PGD_01000A0A024L1H42
Acetyl-CoA carboxylase subunit A (EC 6.4.1.2)VSAK1_13528A6D4J72
Acetyl-CoA carboxylase, biotin carboxylase subunitaccC FTN_0564A0Q5E42
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC 6.4.1.2)accA VSAK1_11700A6D8N62
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta) (Acetyl-CoA carboxylase carboxyltransferase subunit beta) (EC 6.4.1.2)accD FTN_0272A0Q4L52
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta) (Acetyl-CoA carboxylase carboxyltransferase subunit beta) (EC 6.4.1.2)accD PA3112Q9HZA72
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta) (Acetyl-CoA carboxylase carboxyltransferase subunit beta) (EC 6.4.1.2)accD VSAK1_10133A6D0N42
Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme)acsA VSAK1_13543A6D4K02
Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11)argD VSAK1_09328A6D7752
Acetylornithine aminotransferase 2 (ACOAT 2) (EC 2.6.1.11)argD2 BP0451Q7VSH32
Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)aceF PP_0338Q88QZ62
Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)aceF KPR_1048R4Y5U72
Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)aceF VSAK1_04715A6D6A62
Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)aceF AA102_14980 ACN81_28830 ACU90_26810 AM270_11940 BMT53_09785 ERS085374_01749 HW42_04165 RG28_04175A0A0B1IJQ92
Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)ECs0119C3TQA72
Acetyltransferase PA5475 (EC 2.3.1.-) (GCN5-related N-acetyltransferase) (GNAT)PA5475Q9HT952
Acetyltransferase YpeA (EC 2.3.1.-)ypeA BY96_10920A0A027TZQ52
Acid phosphatase (EC 3.1.3.2)Smlt0084B2FU432
Acid phosphatase/phosphotransferase (EC 3.1.3.2)aphA VSAK1_00687A6D1982
Aconitate hydratase (Aconitase) (EC 4.2.1.3)acnA KPR_2324R4Y8902
Aconitate hydratase (Aconitase) (EC 4.2.1.3)acnA BP2014Q7VX122
Aconitate hydratase B (EC 4.2.1.3) (EC 4.2.1.99) (2-methylisocitrate dehydratase)acnB KPR_1053R4Y5U92
Aconitate hydratase B (EC 4.2.1.3) (EC 4.2.1.99) (2-methylisocitrate dehydratase)VSAK1_05085A6D3402
AcrB proteinacrB KPR_4195R4YE632
Acridine efflux pumpacrA SSON_0450Q3Z4T62
Acyl carrier protein (ACP)acpP BP2440Q7VW322
Acyl-homoserine lactone acylase QuiP (AHL acylase QuiP) (Acyl-HSL acylase QuiP) (EC 3.5.1.97) [Cleaved into: Acyl-homoserine lactone acylase QuiP subunit alpha (Acyl-HSL acylase QuiP subunit alpha); Acyl-homoserine lactone acylase QuiP subunit beta (Acyl-HSL acylase QuiP subunit beta)]quiP PP_1108Q88NU62
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129)lpxA FTN_1478A0Q7Y02
AcyltransferaseFTN_1750A0Q8N62
Adapter protein MecAmecA SPy_0281 M5005_Spy0239P601872
Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)apt VSAK1_10088A6D0M52
Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)apt EcE24377A_0506A7ZIM82
Adenosylhomocysteinase (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)ahcY acyH BP3068Q7VUL82
Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase)purB BP2890Q7VV202
Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)purA VSAK1_09938A6D8C82
Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)purA adeK BP2188Q7VWM12
AdhesinfhaS BP2667Q7VVJ22
Adhesin (Bifunctional enterobactin receptor/adhesin protein)BE932_13260 SY51_16895A0A061YB932
Adhesion and penetration proteinhap NMB1985Q9JXL62
ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (ADP-L-glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6-epimerase) (ADP-hep 6-epimerase) (AGME)rfaD hldD VSAK1_09628A6D0G62
ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (ADP-L-glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6-epimerase) (ADP-hep 6-epimerase) (AGME)hldD htrM rfaD BP0955Q7VZF52
Aerobactin siderophore receptor IutA @ TonB-dependent siderophore receptorSGF_00427E7T7F92
Aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.5.3)glpD BSU09300P181582
Agglutination proteinVSAK1_14470A6D4S92
Alanine dehydrogenase (EC 1.4.1.1)VSAK1_00040A6D9992
Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)alaS FTN_0778A0Q6042
Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)alaS lmo1504Q8Y7222
Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)alaS PA0903Q9I5532
Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)alaS VSAK1_02069A6D4F32
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