EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD A1S_0155A3M1442
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD NMB1934Q9JXQ22
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD ACL_0982A9NGW22
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD VSAK1_24595A6D4162
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD Z5230 ECs4674P0ABB62
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD BP3288Q7VU442
ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein)atpE PA5559Q9HT152
ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein)atpE VSAK1_24620A6D4212
ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)atpH VSAK1_24610A6D4192
ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)atpH Z5233 ECs4677P0ABA52
ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)atpH LMRG_01716A0A0H3GJ542
ATP-binding protease component ClpAclpA PA2620Q9I0L82
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfk1 pfkA ACL_1091A9NH712
ATP-dependent Clp protease ATP-binding subunitclpA VSAK1_03992A6D8N02
ATP-dependent Clp protease proteolytic subunitZ0967Q8X8662
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP lmo1138Q8Y7Y12
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP lmo2468Q9RQI62
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP spr0656P637882
ATP-dependent Clp protease, ATP-binding subunit, putativeclpL SPCG_0342B2ISQ72
ATP-dependent endonucleaseBE932_28090 SY51_04490A0A061KP512
ATP-dependent helicase/deoxyribonuclease subunit B (EC 3.1.-.-) (EC 3.6.4.12) (ATP-dependent helicase/nuclease RexB)rexB spr1039Q8DPR72
ATP-dependent protease ATP-binding subunit (Fragment)clpX VSAK1_02419A6D9M12
ATP-dependent protease ATPase subunit HslU (Unfoldase HslU)hslU VSAK1_09513A6D0E32
ATP-dependent protease LA (Fragment)VSAK1_02424A6D9M22
ATP-dependent protease subunit HslV (EC 3.4.25.2)hslV BP3086Q7VUK02
ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A)deaD VSAK1_23749A6D1F92
ATP-dependent RNA helicase RhlB (EC 3.6.4.13)rhlB VSAK1_24199A6D6I82
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH SPy_0015Q9A2002
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH KPR_4781R4YI462
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH)ftsH BSU00690P374762
AutolysinLMRG_02238A0A0H3GJK82
Autolysin, amidaseamiQ8Y4962
Autonomous glycyl radical cofactorgrcA E2348C_2856B7UH182
AutotransporterBP0529Q7VSA82
AutotransporterBP1344Q7VYJ22
Autotransportervag8 BP2315Q79GN72
Autotransporter (Autotransporter outer membrane beta-barrel domain-containing protein)BE932_25200 SY51_01715A0A061Y5782
Autotransporter (Autotransporter outer membrane beta-barrel domain-containing protein) (BapA protein)bapA AV743_07755 ERS005128_00915 ERS005179_01466 ERS1058649_00515Q9F4B42
Autotransporter (Autotransporter outer membrane beta-barrel domain-containing protein) (Phg protein)phg AV743_08970 ERS1058649_00614Q9Z5R32
Autotransporter subtilisin-like proteasesphB1 BP0216Q7W0C92
Azurinazu PA4922P002822
AzurinBP0824P0A3202
Bacterial extracellular solute-binding family proteinHPSD74_0188U4SMX72
Bacterial extracellular solute-binding s, 5 Middle family protein (Fragment)HPSD74_1053U4SH822
Bacterial Ig-like domain (Group 1)/fibronectin type III domain proteinMXAN_5837Q1D0492
Bacterial Ig-like domain proteinMXAN_6749Q1CXK72
Bacterial non-heme ferritin (EC 1.16.3.2)ftn cft Cj0612cQ461062
Bacterial non-heme ferritin (EC 1.16.3.2) (Ferritin-1)ftnA Z2960 ECs2613P0A9A02
Bacteriocin production proteinVSAK1_10118A6D0N12
Bacteriocin-associated integral membrane proteinSP70585_0743C1C6462
Bacterioferritinbfr BP0174Q7W0G12
Bacterioferritin A (BFR A) (EC 1.16.3.1)bfrA NMB1207P0A0R12
Basal-body rod modification protein FlgDflgD PP_4389Q88ER42
Basal-body rod modification protein FlgDflgD VSAK1_02944A6CX812
Beta sliding clampdnaN BP0490Q7VSE12
Beta-D-glucoside glucohydrolase, periplasmicbglX SSON_2189Q3Z0722
Beta-galactosidasebgaA SPCG_0603B2IMV92
Beta-galactosidase (Beta-gal) (EC 3.2.1.23) (Lactase)lacZ BE932_25375 SY51_01870A0A061YHL52
Beta-ketoacyl-(Acyl carrier protein) reductase (EC 1.1.1.100)fabG1 ACL_0463A9NFF22
Beta-ketoacyl-[acyl-carrier-protein] synthase FabY (Beta-ketoacyl-ACP synthase) (KAS) (EC 2.3.1.180) (Beta-ketoacyl synthase KAS I/II domain-containing enzyme)fabY PA5174Q9HU152
Beta-lactam resistance factorSP70585_0677C1C5Y42
Bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein (EC 3.1.4.16)cpdB VSAK1_01779A6D4952
Bifunctional aspartokinase I/homoserine dehydrogenase I (EC 1.1.1.3) (EC 2.7.2.4)thrA VSAK1_14022A6D3N02
Bifunctional aspartokinase/homoserine dehydrogenase 1 (Aspartokinase I/homoserine dehydrogenase I) (AKI-HDI) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)]thrA thrA1 thrA2 b0002 JW0001P005612
Bifunctional enzyme CysN/CysC [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase)]cysNC cysN PA4442O502742
Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase (EC 4.1.1.36) (EC 6.3.2.5)BE932_17385 SY51_20750A0A066T2872
Bifunctional polymyxin resistance protein ArnA [Includes: UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating (EC 1.1.1.305) (UDP-GlcUA decarboxylase) (ArnADH) (UDP-glucuronic acid dehydrogenase); UDP-4-amino-4-deoxy-L-arabinose formyltransferase (EC 2.1.2.13) (ArnAFT) (UDP-L-Ara4N formyltransferase)]arnA VSAK1_04182A6D6672
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]glmU BP3730Q7VT272
Bifunctional protein HldE [Includes: D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase); D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-glycero-beta-D-manno-heptose-7-phosphate kinase) (D-beta-D-heptose 7-phosphotransferase)]hldE VSAK1_04760A6D6B52
Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-beta-D-heptose 7-phosphotransferase) (D-glycero-beta-D-manno-heptose-7-phosphate kinase); D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase)]hldE rfaE PA4996Q9HUG92
Bifunctional protein PutAputA Cj1503cQ0P8B52
Bifunctional protein PutAVSAK1_19429A6CWG62
Bifunctional purine biosynthesis protein PurH [Includes: IMP cyclohydrolase (EC 3.5.4.10) (IMP synthase) (ATIC) (Inosinicase); Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase)]purH BP3416Q7VTU12
Bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic (EC 3.1.3.5)ushA VSAK1_02119A6D9882
Biopolymer transport protein ExbBexbB PP_5306Q88C772
Biosynthetic peptidoglycan transglycosylase (EC 2.4.1.129) (Glycan polymerase) (Peptidoglycan glycosyltransferase MtgA) (PGT)mtgA ACINNAV57_1068L9P5R12
Biosynthetic peptidoglycan transglycosylase (EC 2.4.1.129) (Glycan polymerase) (Peptidoglycan glycosyltransferase MtgA) (PGT)mtgA VSAK1_16887A6CUT82
Biotin carboxyl carrier protein of acetyl-CoA carboxylasefabE BP2997Q7VUS82
Biotin sulfoxide reductaseVSAK1_18032A6CVG72
Bipartate energy taxis response protein cetAcetA Cj1190cQ0P9662
BON domain proteinACINWC487_1281K9BH862
Branched chain amino acid ABC transporter substrate-binding protein (Leucine ABC transporter substrate-binding protein) (Leucine ABC transporter subunit substrate-binding protein LivK)APU18_01265 BK248_05615 BK334_06800 ECONIH1_20155 SY51_19755A0A0A2RKZ22
Branched-chain amino acid aminotransferase (EC 2.6.1.42)ilvE MXAN_2987Q1D8272
Branched-chain amino acid-binding proteinBP1948Q7VX602
Branched-chain amino-acid ABC transport system periplasmic binding proteinlivJ Cj1019cQ0P9N32
Branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42)ilvE BP3398Q7VTV52
BrkA autotransporter [Cleaved into: Serum resistance protein BrkA; BrkA translocator]brkA BP3494Q453402
C4-dicarboxylate ABC transporterBE932_27215 SY51_03640A0A061YFJ32
C4-dicarboxylate transport proteindctA PP_1188Q88NL92
C4-dicarboxylate transport proteinVSAK1_02389A6D9792
C4-dicarboxylate-binding periplasmic proteinVSAK1_02379A6D9772
Calcineurin-like phosphoesterase family proteinHPSD74_0580U4SM382
CAMP factorcfa SPy_1273Q99ZD82
cAMP-activated global transcriptional regulator CRP (Catabolite activator protein) (CAP) (Catabolite gene activator) (cAMP receptor protein) (CRP) (cAMP regulatory protein)crp cap csm b3357 JW5702P0ACJ82
cAMP-regulatory proteinVSAK1_09303A6D7702
Carbamate kinaseVSAK1_15712A6D4Q32
Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase ammonia chain)carB VSAK1_13912A6D3K82
Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase glutamine chain)carA AKG99_14105 AUQ13_08190 BET08_21535 BK248_20715 BK337_05695 BUE81_03390 EC3234A_2c00180A0A0A6REX32
Carbamoyl-phosphate synthase small subunit (EC 6.3.5.5) (Fragment)VSAK1_13907A6D3K72
Carboxy-terminal protease (EC 3.4.21.102)VSAK1_05300A6D6G42
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