EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
GTP pyrophosphokinase (EC 2.7.6.5)relA spr1487Q8DNX12
GTP-binding protein TypA/BipA (Tyrosine phosphorylated protein A)typA spr0598Q8CWS62
GTPase Der (GTP-binding protein EngA)engA der VSAK1_12040A6D2Y42
GTPase Der (GTP-binding protein EngA)der engA EcE24377A_2795A7ZPV42
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) (Guanosine pentaphosphate phosphohydrolase) (pppGpp-5'-phosphohydrolase)gppA A9R57_23900 BHS87_21165 BJJ90_26270 BW690_10240 ERS085416_02711 ERS139211_01489 ERS150873_02224 PGD_00192 SK85_04108A0A024L7522
Heat shock proteinVSAK1_01287A6D2E32
Heat shock protein HslJhslJ ydbI b1379 JW1374P526442
Heat-shock protein IbpAibpA PA3126Q9HZ982
Helix destabilizing protein of bacteriophage Pf1PA0720Q9I5K82
Hemagglutinin AhagA PG_1837P599152
Hemagglutinin protein HagEhagE PG_2024Q7MTE22
Heme transport proteinVSAK1_14737A6D7F82
Heme utilization proteinhup NTHI1390Q4QL822
Heme-binding protein FetBfetB PG_0669Q7MWF22
HemolysinVSAK1_15132A6D3D82
HemX family proteinHPSD74_1108U4SGE22
HemX proteinhemX KPR_0252R4Y7E12
HemY proteinVSAK1_12255A6D6U22
HflK proteinVSAK1_09953A6D8D12
High-affinity amino acid transport system periplasmic binding proteinlivJ SSON_3698Q3YW682
High-affinity zinc uptake system protein ZnuAznuA NTHI0208Q4QP632
Histidine kinase (EC 2.7.13.3)VSAK1_15682A6D4P72
Histidine Motif-Containing proteinphpA spr1060Q8CWR42
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS spr1931Q8DN462
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS ACL_0824A9NGF82
Histidine-binding periplasmic protein (HBP)hisJ STM2354P029102
Histidine-binding periplasmic protein of high-affinity histidine transport systemhisJ SSON_2367Q3YZQ22
Histidinol dehydrogenase (HDH) (EC 1.1.1.23)hisD PA4448Q9HVW92
Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase)hisC BX06_23725A0A027ZUP02
Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase)hisC EC1303_c22010A0A0E1LYP12
Histone proteinbpH1 BP2985Q7VUT92
HlyD family secretion proteinLMRG_02615A0A0H3G9812
HmuY proteinhmuY PG_1551F5HFY52
HMW2B, OMP-85-like protein required for HMW1A and HMW2A secretionhmw2B NTHI1449Q4QL292
Holliday junction resolvase (EC 3.1.22.4)HPSD74_1476U4SI022
Holocytochrome c synthetase subunitccmG PP_4321Q88EY12
Homoserine dehydrogenase (EC 1.1.1.3)BP2784Q7VVA12
HrpA proteinhrpA KPR_2859R4Y9R02
HTH-type transcriptional regulator IscRiscR EcE24377A_2816A7ZPX52
HTH-type transcriptional repressor NsrRnsrR WR15_07000A0A0B0W2Q72
HTH-type transcriptional repressor PurR (Pur regulon repressor) (Purine nucleotide synthesis repressor)purR VSAK1_04067A6D7J82
HtrA proteinhtrA PG_0593Q7MWL52
Hyaluronate lyase (Hyaluronidase/hyase) (EC 4.2.2.1)hysA spr0286Q8CWU32
Hydrolase, alpha/beta fold familyMXAN_0220Q1DFS12
Hydrolase, alpha/beta fold familyMXAN_0201Q1DFU02
Hydroxyethylthiazole kinase (EC 2.7.1.50) (4-methyl-5-beta-hydroxyethylthiazole kinase) (TH kinase) (Thz kinase)thiM VSAK1_18649A6CXQ72
Hydroxymethylpyrimidine-binding proteinVSAK1_11990A6D2X42
Hyperosmotically inducible periplasmic proteinosmY STM4561Q7CP682
Hypothetical ABC transporter, substrate binding proteinVSAK1_15812A6CYN02
Hypothetical C4-dicarboxylate binding proteinVSAK1_02649A6CX222
Hypothetical Flp pilus assembly proteinVSAK1_05920A6CZH42
Hypothetical glucose dehydrogenaseVSAK1_03389A6CXH02
Hypothetical membrane proteinFTN_1260A0Q7C62
Hypothetical myo-inositol 2-dehydrogenaseVSAK1_25190A6CZ942
Hypothetical myo-inositol catabolismprotein iolBVSAK1_25145A6CZ852
Hypothetical outer membrane cobalamin receptor protein (Fragment)VSAK1_13281A6D9592
Hypothetical outer membrane cobalamin receptor protein (Fragment)VSAK1_13286A6D9L62
Hypothetical surface-anchored proteinACL_0387A9NF792
Hypothetical surface-anchored proteinACL_0210A9NEQ62
Hypothetical surface-anchored proteinACL_0662A9NFZ82
Hypothetical surface-anchored proteinACL_0672A9NG082
Hypothetical surface-anchored proteinACL_1409A9NE402
Hypothetical surface-anchored proteinACL_1407A9NE382
Ig-like repeat domain protein 1VSAK1_03875A6D3W32
IgA-specific serine endopeptidase (EC 3.4.21.72)iga NMB0700Q9K0B42
Imidazole glycerol phosphate synthase subunit HisH (EC 2.4.2.-) (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH)hisH BE932_07575 SY51_11755A0A066SZX52
Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19)hisB BP3770Q7VSY92
Immunogenic proteinVSAK1_18414A6CXL02
Immunogenic proteinVSAK1_07639A6D3K52
Immunogenic secreted-like proteinisp2 SPy_1801Q99Y992
Immunoreactive 47 kDa antigen PG97PG_1374F5HDB62
Immunoreactive 61 kDa antigen PG91PG_2102F5HI792
Increased serum survival (Lambda prophage Bor protein)iss bor ACN002_0555Q2V5132
Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48)trpC BP3261Q7VU672
Indole-3-glycerol phosphate synthase (IGPS) (PRAI) (EC 4.1.1.48) (EC 5.3.1.24) (N-(5'-phosphoribosyl)anthranilate isomerase)trpF trpC VSAK1_01007A6D5692
Inhibitor of complement-mediated lysissic SPy_2016Q7DAL12
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)ppa BP2533Q7VVV32
Inorganic triphosphataseBE932_14165 SY51_17710A0A066STK92
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205)guaB FTN_0661A0Q5N82
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205)guaB BP2625Q7VVM32
Inositol monophosphate family proteinVSAK1_14307A6D7552
Insulinase family proteinHPSD74_1113U4SGE72
IntegraseBX23_01905A0A028DPV02
Internalin BinlB lmo0434P251472
Internalin-related proteinPG_0350Q7MX642
Intracellular growth locus protein BiglB FTN_1323A0Q7I42
Iron ABC transporter substrate-binding protein (Preprotein translocase YidC) (Preprotein translocase subunit YidC)fhuD_1 fhuD_2 APT94_26070 BE949_25275 BIQ85_17105 BK375_12040 BK383_02220 BMT97_12000 BUE82_02815 ERS085383_00861 ERS085386_00648 ERS085404_02597 GJ11_19910 JD73_01060 SM09_03310 UC41_12845A0A023KTM22
Iron binding protein FbpAfbpA HPSD74_1065U4SJ642
Iron complex transport system substrate-binding proteinLMRG_00535A0A0H3GB262
Iron(3+)-hydroxamate-binding protein FhuD (Ferric hydroxamate uptake protein D) (Ferrichrome-binding protein) (Iron(III)-hydroxamate-binding protein FhuD)fhuD BSU33320P375802
Iron(III) ABC transporter, periplasmic iron-compound-binding protein (Fragment)VSAK1_08024A6D7U32
Iron(III) dicitrate transport protein (FecA)HP_1400O259502
Iron-regulated protein FrpCVSAK1_19279A6CY332
Iron-sulfur cluster carrier proteinVSAK1_03449A6CXI22
Iron-utilization periplasmic protein hFbpAhitA NTHI0177Q4QP872
Isocitrate dehydrogenaseVSAK1_03967A6D8M52
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)icd_3 icd icd_2 icdA AGG09_03900 BB749_16865 BL143_19960 BN49_2233 PMK1_03484 SAMEA3531778_05647 SAMEA3531848_00953 SM57_02359F1DFL42
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)icd BP2488Q7VVZ22
Isocitrate dehydrogenase [NADP] (IDH) (EC 1.1.1.42) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)icd icdA icdE b1136 JW1122P082002
Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)ileS ACL_0702A9NG382
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