EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)ileS VSAK1_11073A6D8Q52
Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)ileS BP1753Q7VXK32
Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase)ilvC VSAK1_12727A6D8R22
Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I)ilvC NMB1574Q9JYI22
Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I)ilvC BP0791Q7VZU42
Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 2) (Ketol-acid reductoisomerase type II)ilvC SSON_3945Q3YVJ02
Ketose bisphosphate aldolase, class-II (EC 1.1.-.-)ACL_1395A9NE262
Kinase inhibitorBX52_17595A0A0E2TRG62
L,D-carboxypeptidase A (EC 3.4.17.13) (Muramoyltetrapeptide carboxypeptidase)ldcA BE932_30450 SY51_06785A0A061KLZ82
L,D-transpeptidaseA4T50_02705 APU18_07990 BE932_06525 SY51_11350 WM48_10545A0A066SZT02
L,D-transpeptidase (Murein L,D-transpeptidase)BE932_28875 SY51_05250A0A061YK912
L-allo-threonine aldolaseVSAK1_23669A6CWE02
L-arabinose-binding periplasmic protein (ABP)araF AML35_08420 ARC77_04400 AU473_20470 AWP75_01775 BE932_05385 BWP17_07245 BXT93_06945 ECs2609 ERS085383_03474 ERS085386_04309 ERS085404_00073 GJ11_12910 JD73_24250 SY51_10515C3T5A22
L-asparaginase 2 (EC 3.5.1.1) (L-asparaginase II) (L-ASNase II) (L-asparagine amidohydrolase II) (Colaspase)ansB b2957 JW2924P008052
L-cystine-binding protein FliY (CBP) (Protein FliY) (Sulfate starvation-induced protein 7) (SSI7)fliY yzzR b1920 JW1905P0AEM92
L-cystine-binding protein TcyAtcyA yckK BSU03610P421992
L-cystine-binding protein tcyAtcyA HPSD74_1320U4SJ022
L-fuculose phosphate aldolase (EC 4.1.2.17)fucA spr1972Q8DN172
L-lactate dehydrogenase (L-LDH) (EC 1.1.1.27)ldh lctE BSU03050P137142
L-serine deaminaseVSAK1_07089A6D4W52
L-serine dehydratase 1VSAK1_07219A6D4Z12
L-threonine dehydratase (EC 4.3.1.19) (Threonine deaminase)ilvA spr0406Q8DR022
Lactate oxidase (EC 1.1.3.-)lctO spr0627Q8DQK72
Large-conductance mechanosensitive channelmscL PA4614Q9HVH72
Large-conductance mechanosensitive channelmscL LMRG_01214A0A0H3GDR62
LemA family proteinAB237_0291A0A0E1PMW82
LemA-like proteinFTN_0391A0Q4X92
Leu/ile/val-binding proteinlivJ BP1277Q7VYN82
Leu/ile/val-binding proteinlivJ BP1285Q7VYN12
Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)leuS FTN_0870A0Q6932
Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)leuS PA3987Q9HX332
Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)leuS ACL_0242A9NET82
Leucine-responsive transcriptional regulatorVSAK1_00045A6D9A02
Leucine-specific binding proteinlivK SFV_3461Q0SZL42
Leucyl-tRNA synthetase (EC 6.1.1.4) (Fragment)leuS VSAK1_08793A6D9E02
LexA repressor (EC 3.4.21.88)lexA EcE24377A_4596A7ZUR52
Lichenan-specific phosphotransferase enzyme iib component (Pts system lichenan-specific eiib component) (Eiib-lic) (EC 2.7.1.69)SP70585_1864C1C9572
Lipaselip1 AB237_2508A0A0E1PU382
Lipase, putativeVSAK1_20549A6CY872
Lipid A export ATP-binding/permease protein MsbA (EC 3.6.3.-)msbA FTN_1606A0Q8A12
Lipopolysaccharide core heptose(II)-phosphate phosphatase (EC 3.1.3.-)ais SSON_2313Q3YZV42
Lipopolysaccharide core heptose(II)-phosphate phosphatase (EC 3.1.3.-)ais A4T40_16595 BK334_03310 ECONIH1_13160 MS6198_25870A0A0A1A6A62
Lipopolysaccharide export system protein LptAlptA NMB0355Q7DDQ92
Lipopolysaccharide export system protein LptAlptA PP_0954Q88P982
Lipopolysaccharide export system protein LptAyhbN lptA SSON_3348Q3YX412
Lipopolysaccharide export system protein LptAlptA VSAK1_01949A6D4C92
Lipopolysaccharide export system protein LptAlptA BP0698Q7W0102
Lipopolysaccharide export system protein LptClptC PA4459Q9HVV82
LipoproteinNMB1946Q7DD632
LipoproteinnlpC STM1343Q8ZPS72
LipoproteinvacJ STM2392Q7CQ322
LipoproteinSPy_0319Q9A1E42
LipoproteinnlpD SSON_2890Q3YYC02
LipoproteinHPSD74_0538U4SMP32
LipoproteinmetQ VSAK1_10558A6D8S92
LipoproteinyaeC metQ A5958_05280 AA102_15410 AC789_1c01960 ACN002_0204 ACN77_02985 ACN81_21815 AKG99_06615 AM270_26180 AMK83_28465 AML07_03410 AML35_22730 APT94_20140 APZ14_14710 AUS26_27525 BE949_16180 BE957_24175 BE963_14980 BIQ85_00980 BK251_11315 BK292_13820 BK375_04500 BK383_20095 BK400_03465 BMT53_09360 BMT61_25200 BMT91_01220 BMT94_04850 BN17_46211 BUE82_19830 BXT93_05345 ERS085365_03057 ERS085366_02749 ERS085374_05170 ERS085379_05378 ERS085416_04559 ERS139211_02957 ERS139235_01384 ERS150876_00004 GJ12_01025 HMPREF3040_02639 HW42_04580 JD73_12995 PU06_12030 RG28_03755 SM09_00939 UC41_07565 UN86_07855 UN91_10435 WQ89_09700 WR15_02475J7QMA12
LipoproteinBY96_19305A0A027U7022
LipoproteinBP1189Q7VYW42
LipoproteinBP2750Q7VVC72
LipoproteinBP2782Q7VVA32
LipoproteinBP2818Q7VV702
LipoproteinLMRG_02586A0A0H3GDK32
Lipoprotein BlcVSAK1_06829A6D5132
Lipoprotein copper homeostasis and adhesion, NlpEnlpE HPSD74_0253U4SNT02
Lipoprotein NlpCVSAK1_05455A6D5N52
Lipoprotein NlpIVSAK1_10968A6D2412
Lipoprotein RagBragB PG_0186F5H9482
Lipoprotein YgeR (Murein hydrolase activator NlpD)nlpD_1 A4T40_19660 APT94_04695 BE949_26330 BIQ85_15955 BK248_13345 BK334_11385 BK373_15415 BK375_08035 BK383_12200 BMT94_08165 BMT97_17475 BUE82_03830 ECONIH1_16520 MS6198_32050 SM09_03028 UC41_04440A0A023L6532
Lipoprotein, NlpC/P60 familyEc53638_5043A0A0E1T3F22
Lipoprotein, putativePG_0188Q7MXJ62
Lipoprotein, putativePG_1835Q7MTV02
Lipoprotein, putativePG_2105Q7MT762
Lipoprotein, putativeVSAK1_12215A6D8752
Lipoprotein-related proteinVSAK1_10453A6D0U82
Listeriolysin O (LLO) (Thiol-activated cytolysin)hly hlyA lisA lmo0202P131282
Lmo0098 proteinlmo0098Q8YAM02
Lmo0152 proteinlmo0152Q8YAH42
Lmo0181 proteinlmo0181Q8YAE92
Lmo0413 proteinlmo0413Q8Y9V72
Lmo0592 proteinlmo0592Q8Y9D82
Lmo0724 proteinlmo0724Q8Y9182
Lmo0847 proteinlmo0847Q8Y8P92
Lmo0859 proteinlmo0859Q8Y8N72
Lmo1226 proteinlmo1226Q8Y7P72
Lmo1351 proteinlmo1351Q8Y7D22
Lmo1389 proteinlmo1389Q8Y7A12
Lmo1438 proteinlmo1438Q8Y7632
Lmo1601 proteinlmo1601Q7AP592
Lmo1649 proteinlmo1649Q8Y6N52
Lmo1757 proteinlmo1757Q8Y6D12
Lmo1820 proteinlmo1820Q8Y6792
Lmo1851 proteinlmo1851Q8Y6492
Lmo1861 proteinlmo1861Q8Y6392
Lmo2056 proteinlmo2056Q8Y5K42
Lmo2061 proteinlmo2061Q8Y5J92
Lmo2185 proteinlmo2185Q7AP542
Lmo2186 proteinlmo2186Q8Y5852
Lmo2196 proteinlmo2196Q7AP522
Lmo2229 proteinlmo2229Q8Y5472
Lmo2371 proteinlmo2371Q8Y4R32
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