EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Oligopeptidase ABE932_16470 BK373_21290 MJ49_12820 SY51_19950A0A066T0J16
Outer membrane proteinyoaF AM270_02980 AML07_21025 APZ14_27125 AUS26_11860 BMT53_01055 BMT61_01720 ERS085374_01278 ERS150876_03574 FORC28_3792 WQ89_08900A0A066QFW96
Outer membrane protein (Omp15)HP_0706O254106
Outer membrane protein (Omp25)HP_1156O257716
Outer membrane protein (Omp8)HP_0254O250366
Outer membrane protein assembly factor BamCnlpB bamC ECED1_2912B7MYB66
Outer membrane protein assembly factor BamCnlpB bamC A4T40_17630 A4T50_05915 APU18_00520 BE932_09965 BK334_04345 BMT49_15955 ECONIH1_14195 ERS085406_01950 MS6198_27960 SY51_14295 WM48_13075E2QPV26
Outer membrane protein assembly factor BamDbamD PA4545P336416
Outer-membrane lipoprotein LolBlolB BE932_30715 SY51_07050A0A061YFK06
OxidoreductaseBE932_16170 SY51_19660A0A061K5J16
OxidoreductaseUN91_28095A0A0F3UMD06
Oxidoreductase (Quinone oxidoreductase)BE932_15155 SY51_18660A0A066SYQ66
Peptidase T (EC 3.4.11.4) (Aminotripeptidase) (Tripeptidase) (Tripeptide aminopeptidase)pepT BY96_03380A0A027U4446
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)fkpA ECED1_4008B7N0Y36
Peptigoglycan-binding protein LysMAKG99_21515 JD73_25065 UN91_19610A0A066QL246
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)pheS E2348C_1843B7US976
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)pheT BE932_04010 SY51_09540A0A061YG466
Phosphoanhydride phosphorylaseBE932_29140 SY51_05510A0A066SNI46
Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Phosphotransferase system, enzyme I)BE932_09695 SY51_14035A0A066T3J06
Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphate isomerase)lpcA gmhA UTI89_C0262Q1RFU96
Phosphomannomutase/phosphoglucomutase (PMM / PGM) (EC 5.4.2.2) (EC 5.4.2.8)algC PA5322P262766
Polyamine-transporting ATPase (EC 3.6.3.31)spuF PA0302Q9I6I96
Polysialic acid transport protein KpsD (Polysialic acid transporter)kpsD ECONIH1_17505 MS6198_34040A0A0A1AEM16
Probable acyl-CoA thiolasePA2553Q9I0T16
Probable aldehyde dehydrogenasePA5312Q9HTP26
Probable bacteriophage proteinPA0641Q9I5S56
Probable binding protein component of ABC sugar transporterPA3190Q9HZ486
Probable dna-binding stress proteinPA0962Q9I4Z76
Probable hemagglutininPA0041Q9I7916
Probable phosphoglycerate mutase GpmB (EC 5.4.2.-) (PGAM) (Phosphoglyceromutase)pspB_2 gpmB A4T40_03270 BK334_15950 ECONIH1_26340 MS6198_51790A0A0A1AJ166
Probable porinPA3038Q9HZH06
Protease HtpX (EC 3.4.24.-) (Heat shock protein HtpX)htpX PA2830Q9I0136
Protein CsiDcsiD BE932_11215 SY51_14970A0A061L5496
Protein ElaBBX52_12345A0A0E2TRU36
Protein RecA (Recombinase A)recA EcE24377A_2983A7ZQC86
Protein translocase subunit SecAsecA EcE24377A_0100A7ZHI96
PslDpslD PA2234Q9I1N56
PTS system mannose-specific EIIAB component (EC 2.7.1.191) (EIIAB-Man) (EIII-Man) [Includes: Mannose-specific phosphotransferase enzyme IIA component (PTS system mannose-specific EIIA component); Mannose-specific phosphotransferase enzyme IIB component (PTS system mannose-specific EIIB component)]manX Z2860 ECs2527P697996
Putative hydrolase, isochorismatase familyycaC CE10_0923A0A0E0V3T96
Putative isovaleryl-CoA dehydrogenaseliuA PA2015Q9I2966
Putative lipoprotein (Putative uncharacterized protein)ACN002_2828 ACN77_06930 ACN81_20235 ACN87_17325 AWP75_20465 BE932_11995 BE949_26730 BE957_08705 BE963_03810 BN17_26951 BUE81_06825 BUE82_04235 BV389_00140 BW690_04825 BWP17_05030 BXT93_09270 ECs3669 HMPREF3040_01196C3SWS26
Putative universal stress protein (Universal stress protein F)uspF A5958_24845 AA102_23395 ACN77_11910 ACN81_14150 ACU90_19595 AM270_05080 AMK83_00415 BE957_16780 BHS81_09545 BK251_04410 BK292_03775 BMT53_03340 BMT61_07810 ERS085374_00575 ERS085379_01708 ERS139235_02071 GJ12_09235 HW42_11235 PU06_28630 RG28_15410 UN86_23895 WQ89_18590A0A066R3Y76
Putrescine-binding periplasmic protein SpuDspuD PA0300Q9I6J16
Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase)proC BE932_25540 SY51_02030A0A061KQD06
Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase)proC A4T40_05255 BE963_16065 BK248_04640 BK334_05970 BV389_16735 ECONIH1_02110 HMPREF3040_03382 MS6198_03860 UN91_18755A0A023L0N56
Pyruvate dehydrogenase (Pyruvate oxidase)A4T50_19220 BE932_28055 SY51_04460A0A066SYL56
Pyruvate kinase (EC 2.7.1.40)A4T50_01800 BE932_04790 BET08_18910 BK248_11035 SY51_10285 WM48_09515E2QN586
RegulatorA4T50_14840 APU18_20045 BE932_19795 BET08_11120 SY51_23290A0A061YFX76
Ribonucleoside-diphosphate reductase 1 subunit beta (EC 1.17.4.1) (Protein B2) (Protein R2) (Ribonucleotide reductase 1)nrdB ftsB Z3491 ECs3118P699256
Ribosomal large subunit pseudouridine synthase B (EC 5.4.99.22) (23S rRNA pseudouridine(2605) synthase) (rRNA pseudouridylate synthase B) (rRNA-uridine isomerase B)rluB c1734Q8FHV46
Ribosomal RNA small subunit methyltransferase C (EC 2.1.1.172) (16S rRNA m2G1207 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase RsmC)rsmC ECED1_5241B7MTB66
Ribosome-recycling factor (RRF) (Ribosome-releasing factor)frr EcE24377A_0176A7ZHR26
Secreted protein involved in flagellar motilityHP_1462O259986
Serralysin (EC 3.4.24.40) (Alkaline metalloproteinase) (AP)aprA PA1249Q030236
Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I)lepB PA0768Q9I5G76
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA ECUMN_0801B7N9W26
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB A4T40_07235 A4T50_18480 A5958_02505 A9R57_13190 AA102_18005 AC789_1c07580 ACN002_0731 ACN77_25325 ACN81_12465 ACN87_25605 ACU90_09540 AM270_21485 AMK83_02780 AML35_15000 APT94_25285 APU18_20490 ARC77_23215 AU473_22965 AUS26_19045 AWP75_10150 BE932_27260 BE949_13505 BE957_21140 BE963_17765 BHF46_14770 BHS81_04210 BHS87_03850 BIQ85_04455 BJJ90_18700 BK248_02595 BK251_08360 BK292_21825 BK334_19330 BK373_24365 BK375_23730 BK383_18315 BMT49_05180 BMT53_06530 BMT61_20775 BMT97_19575 BN17_05011 BUE82_17100 BW690_11470 BWP17_19980 BXT93_02850 ECONIH1_04075 ECs0749 ERS085365_02301 ERS085374_03673 ERS085379_03655 ERS085383_03973 ERS085404_03322 ERS085406_01578 ERS085416_03087 ERS139211_03551 ERS139235_04126 ERS150873_02646 GJ11_03995 GJ12_04295 HW42_07430 JD73_10235 MJ49_02930 MS6198_07780 PGD_02609 PU06_04180 RG28_00935 SY51_03680 UC41_03710 UN86_13180 WM48_03735 WQ89_22975C3TIN26
Succinyl-diaminopimelate desuccinylase (SDAP desuccinylase) (EC 3.5.1.18) (N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase)dapE EcE24377A_2751A7ZPR56
Sulfate transporter subunitBE932_18995 SY51_22525A0A061YJV06
SulfurtransferaseynjE A4T50_01280 BE932_04245 ERS085406_02802 SY51_09760A0A066SS336
Thiosulfate transporter subunitBE932_09735 BMT49_15720 SY51_14075E2QPR06
TonB-dependent receptor (TonB-dependent siderophore receptor)BE932_14025 SY51_17570A0A061KI806
TPR repeat-containing protein PA4667PA4667P428106
Transaldolase (EC 2.2.1.2)tal A4T40_17555 BK248_17065 BK334_04265 ECONIH1_14115 MS6198_27810A0A0A1A7L96
Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho)rho AC789_1c41660 ACN002_3874 EL75_4398 EL79_4648 EL80_4555A0A0A0GPI66
Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho)rho Z5293 ECs4716P0AG326
Transcriptional regulatory protein RcsBrcsBP0DMC86
Transcriptional regulatory protein RcsBrcsB CDCO157_2870A0A0F6C6S36
Transcriptional repressor NrdRnrdR EcE24377A_0444A7ZIG66
tRNA-modifying protein YgfZygfZ BE932_12545 SY51_16290A0A061L4716
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)mnmA A4T40_09800 APT94_20485 BE932_29885 BE949_11260 BE963_20075 BIQ85_06680 BK248_11685 BK334_16870 BK375_24965 BK383_03415 BMT97_12630 BUE82_14135 ECONIH1_06915 MS6198_12700 SY51_06235 UC41_28130A0A023KWH66
Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)trpS G2583_4081D3QTK16
Type II secretion system protein D (T2SS protein D) (General secretion pathway protein D)xcpQ PA3105P358186
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC 2.1.1.163) (EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase) (Demethylmenaquinone methyltransferase)ubiE EcE24377A_4354A7ZU406
Uncharacterized proteinPA0537Q9I5Z96
Uncharacterized proteinPA0588Q9I5U96
Uncharacterized proteinPA4842Q9HUW86
Uncharacterized proteinPA4394Q9HW126
Uncharacterized proteinPA3848Q9HXF86
Uncharacterized proteinPA3716Q9HXS56
Uncharacterized proteinPA0955Q9I5036
Uncharacterized proteinPA3923Q9HX906
Uncharacterized proteinPA0625G3XD836
Uncharacterized proteinHP_0486O252306
Uncharacterized proteinHP_0914O255726
Uncharacterized proteinHP_0605O253266
Uncharacterized proteinHP_0204O249966
Uncharacterized proteinHPY1786_07125A0A0B2E6E66
Uncharacterized proteinHP_0836O255076
Uncharacterized proteinPA0040Q9I7926
Uncharacterized proteinBX23_15665A0A028E4C86
Uncharacterized proteinEcSMS35_4693B1LRA06
Uncharacterized proteinEcSMS35_2935B1LQY86
Uncharacterized proteinEcSMS35_3313B1LF126
Uncharacterized protein HP_0135HP_0135P646556
Uncharacterized protein YecFyecF c2329P0AD086
Uncharacterized protein YqjDyqjD Z4452 ECs3980P645836
Universal stress protein AuspA Z4895 ECs4367P0AED26
UPF0304 protein YfbUyfbU EcE24377A_2587A7ZPA86
UPF0325 protein YaeHyaeH EcE24377A_0168A7ZHQ56
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