EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Serine-type D-Ala-D-Ala carboxypeptidaseHMPREF0010_01990D0CB602
Serine/threonine transporter SstT (Na(+)/serine-threonine symporter)sstT VSAK1_19274A6CY322
Serine/threonine-protein kinase StkP (Ser/Thr-protein kinase StkP) (EC 2.7.11.1) (Eukaryotic-type Ser/Thr protein kinase) (ESTPK)stkP pkn2 spr1577Q8DNS02
Serotype 2 fimbrial subunitfim2 BP1119P057882
Serotype 3 fimbrial subunitfim3 BP1568P178352
Short chain dehydrogenaseFTN_1535A0Q8352
Sialic acid synthaseVSAK1_09593A6D0F92
Sialic acid-binding periplasmic protein SiaP (Extracytoplasmic solute receptor protein SiaP) (N-acetylneuraminic-binding protein) (Neu5Ac-binding protein)siaP NTHI0232Q4QP412
Sigma factor AlgU regulatory protein MucBmucB algN PA0764P381082
Sigma-E factor regulatory protein RseBrseB NTHI0716Q4QMW42
Signal peptidase I (EC 3.4.21.89)lepB ABSDF0950B0VTM32
Signal peptidase I (EC 3.4.21.89)spi SPy_1842Q99Y692
Signal peptidase I (EC 3.4.21.89)sipC SPy_1281Q99ZD22
Signal peptidase I (EC 3.4.21.89)SPy_0127Q9A1S32
Signal peptidase I (EC 3.4.21.89)lepB Smlt3551B2FPY12
Signal peptidase I (EC 3.4.21.89)LMRG_00721A0A0H3GC682
Signal peptidase I (EC 3.4.21.89)LMRG_00719A0A0H3GFV82
Signal peptidase I S (SPase I) (EC 3.4.21.89) (Leader peptidase I)sipS BSU23310P286282
Signal peptidase I T (SPase I) (EC 3.4.21.89) (Leader peptidase I)sipT BSU14410P710132
Signal peptide peptidase SppA, 36K type (EC 3.4.-.-)sppA MXAN_2480Q1D9H32
Signal peptide proteinAB237_1248A0A0E1PPJ82
Signal peptide protein (TPR repeat containing exported protein Putative periplasmic protein contains a protein prenylyltransferase domain) (Tetratricopeptide repeat family protein)A7M90_02125 A7N09_14000 AB988_3800 ABUW_1746 APD06_00085 AZE33_11460 IX87_21615A0A059ZHT52
Signal recognition particle protein (Fifty-four homolog)ffh FTN_0843A0Q6662
Signal recognition particle protein (Fifty-four homolog)ffh spr1166Q8DPH12
Signal recognition particle protein (Fifty-four homolog)ffh VSAK1_04645A6D9642
Signal recognition particle protein (Fifty-four homolog)ffh BP0079Q7W0M32
Signal recognition particle receptor FtsY (SRP receptor)ftsY BP3473Q7VTP22
Single-stranded DNA-binding protein (SSB)ssbD0Z6Q92
Single-stranded DNA-binding protein (SSB)BY96_06515A0A027SYA92
Single-stranded DNA-binding protein (SSB)ssb BP3662P668462
Site-determining proteinminD FTN_0330A0Q4S12
Site-determining proteinminD BP3228Q7VU922
Site-determining proteinLMRG_01426A0A0H3GKH42
Small ribosomal subunit biogenesis GTPase RsgA (EC 3.6.1.-)rsgA UN91_24865A0A0F3UXL72
Small subunit ribosomal protein S1rpsA ACL_0875A9NGK82
SN-glycerol-3-phophate ABC transporter, periplasmic SN-glycerol-3-phosphate-binding proteinVSAK1_01342A6D2F42
Sodium-type flagellar protein MotYVSAK1_03610A6D3R02
Sodium/proline symporterVSAK1_19419A6CWG42
Soluble lytic murein transglycosylaseAB237_2394A0A0E1PSR82
Soluble lytic murein transglycosylaseslt SSON_4542Q3YU022
Soluble lytic murein transglycosylaseVSAK1_17557A6CV722
Soluble lytic murein transglycosylase (Slt)HP_0645O253622
Spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding proteinpotD-1 NMB0462Q9K0U82
Spermidine/putrescine ABC transporter-periplasmic subunitspuE PP_5180Q88CK02
Starvation-inducible outer membrane lipoproteinVSAK1_09068A6D5W62
Streptolysin O (Thiol-activated cytolysin)slo SPy_0167 M5005_Spy0141P0C0I32
Stress-induced protein UspEVSAK1_11580A6D6D22
Stringent starvation protein AsspA VSAK1_04850A6D9I32
Stringent starvation protein AsspA BP0274Q7W0832
Subtilase family proteinHPSD74_1715U4SDX32
Subunit of a proton-driven complex used for maintenance of outer membrane stabilitytolQ PP_1219Q88NI82
Succinate dehydrogenase cytochrome b556 large membrane subunit (EC 1.3.5.1)sdhC VSAK1_08928A6D5T82
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA b0723 JW0713P0AC412
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA KPR_3848R4YD022
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA VSAK1_08938A6D5U02
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA BP2361Q7VWA12
Succinate dehydrogenase hydrophobic membrane anchor subunitsdhD PP_4192Q88FA62
Succinate dehydrogenase hydrophobic membrane anchor subunitVSAK1_08933A6D5T92
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB FTN_1636A0Q8C92
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)frdB Cj0410Q0PBA02
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB b0724 JW0714P070142
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB VSAK1_08943A6D5U12
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)VSAK1_11293A6D8Y32
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB AKG99_04920 BK400_14615 BV389_03980 UN91_17205A0A066R0H32
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB AML07_25800 APZ14_20695 FORC28_4255A0A0F3VHB62
Succinate dehydrogenase membrane b-556 subunit (EC 1.3.5.1)sdhC PP_4193Q88FA52
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD FTN_0593A0Q5H32
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD Cj0534Q0PAY22
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD b0729 JW0718P0AGE92
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD VSAK1_08963A6D5U52
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD BP2540Q7VVU62
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC FTN_0594A0Q5H42
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC b0728 JW0717P0A8362
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC Cj0533Q9PHY12
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC KPR_3844R4YCF42
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC VSAK1_08958A6D5U42
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC EcE24377A_0754A7ZJA82
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC BP2541Q7VVU52
Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)gabD BP1976Q7VX442
Succinyl-diaminopimelate desuccinylase (SDAP desuccinylase) (EC 3.5.1.18) (N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase)dapE AML07_10855 APZ14_05930 FORC28_1490A0A0F3WAE42
Sucrose phosphorylase (EC 2.4.1.7) (Sucrose glucosyltransferase)gtfA spr1709Q8CWP42
Sulfatase, putativeVSAK1_01177A6D5A32
Sulfate transport protein (ABC superfamily, peri_bind)sbp ABSDF0281B0VPF82
Sulfate-binding proteinsbp BP0966Q7VZE62
Sulfate-binding protein of ABC transportercysP PA1493Q9I3L92
Sulfate/thiosulfate import ATP-binding protein CysA (EC 3.6.3.25) (Sulfate-transporting ATPase)cysA PA0280Q9I6L02
Sulfite reductase [NADPH] flavoprotein alpha-component (SiR-FP) (EC 1.8.1.2)cysJ BE932_11750 SY51_15500A0A066SYL92
Sulfur acceptor protein CsdL (tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA)AKG99_03720 BHF46_05215 BK373_15715 BV389_00155 MJ49_16940 UN91_03480A0A066QTV72
SulfurtransferasePP_5055Q88CX52
Superoxide dismutase (EC 1.15.1.1)sodA ACL_0302A9NEZ42
Superoxide dismutase (EC 1.15.1.1)sodA Smlt3238B2FLH12
Superoxide dismutase [Cu-Zn] (EC 1.15.1.1)sodC NMB1398Q596232
Superoxide dismutase [Cu-Zn] (EC 1.15.1.1)sodC HMPREF0010_02564D0CCT42
Superoxide dismutase [Cu-Zn] (EC 1.15.1.1)BP2067Q7VWW92
Superoxide dismutase [Fe] (EC 1.15.1.1)sodB BP2761P373692
Superoxide dismutase [Mn] (EC 1.15.1.1)sodA sod lmo1439P287642
Superoxide dismutase [Mn] (EC 1.15.1.1) (General stress protein 24) (GSP24)sodA yqgD BSU25020P543752
Surface lipoproteindppA SPy_2000Q99XV92
Surface-anchored VWFA domain proteinACL_0449A9NFD92
SWF/SNF family ATP-dependent RNA helicasesnf spr1375Q8DP392
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