EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Translation initiation factor IF-1infA PA2619P651162
Translation initiation factor IF-2infB lmo1325Q8Y7F62
Translation initiation factor IF-2infB ACL_0320A9NF122
Translation initiation factor IF-2infB VSAK1_10993A6D2462
Translation initiation factor IF-3infC E2348C_1847B7USA12
Translation initiation factor IF-3infC BP1498Q7VY632
Transport protein ComBcomB spr0044P596542
Transport/processing ATP-binding protein ComA (EC 3.4.22.-)comA spr0043P596532
Transporter, MotA/TolQ/ExbB proton channel familyMXAN_1448Q1DCB82
Transposase, Mutator family protein (Fragment)HPSD74_0874U4SJR02
TRAP dicarboxylate transporter-DctP subunitVSAK1_23499A6CWA62
TRAP transporter solute receptor, TAXI family proteinHPSD74_2005U4S9V82
TRAP-type C4-dicarboxylate transport system, periplasmic componentVSAK1_23239A6CW542
TRAP-type C4-dicarboxylate transport system, periplasmic componentVSAK1_18949A6CXW72
TRAP-type C4-dicarboxylate transport system, periplasmic componentVSAK1_21364A6CZR72
TRAP-type C4-dicarboxylate transport system, periplasmic componentVSAK1_18299A6D8J52
TRAP-type mannitol/chloroaromatic compound transport system, periplasmic componentVSAK1_05740A6CZD82
Trehalose repressortreR BX06_21965A0A027ZZ442
Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA) (UDP-glucose-glucosephosphate glucosyltransferase)otsA SSON_1221Q3Z2S42
Tresponse regulator proteinrisA BP3554Q79GE22
Tricarboxylate-specific outer membrane porin (EC 3.4.21.-)opdH PP_1419Q88MZ92
Tricarboxylic transport proteinSTM2786Q9FA462
Tricorn protease homolog (EC 3.4.21.-)VSAK1_25615A6D2N52
Trigger factor (Fragment)tig VSAK1_02409A6D9R92
Trigger factor (TF) (EC 5.2.1.8) (PPIase)tig NMB1313Q9JZ372
Trigger factor (TF) (EC 5.2.1.8) (PPIase)tig FTN_1058A0Q6T02
Trigger factor (TF) (EC 5.2.1.8) (PPIase)tig Cj0193cQ461082
Trigger factor (TF) (EC 5.2.1.8) (PPIase)tig ACL_0535A9NFM32
Trigger factor (TF) (EC 5.2.1.8) (PPIase)tig KPR_4321R4YHL82
Trigger factor (TF) (EC 5.2.1.8) (PPIase)tig BP1774Q7VXI82
Trigger factor (TF) (EC 5.2.1.8) (PPIase) (Vegetative protein 2) (VEG2)tig yzzH BSU28230P806982
Trimethylamine-N-oxide reductaseVSAK1_04372A6D8142
Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)tpiA ACL_1206A9NHH52
Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)tpiA tpi BSU33920P278762
Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)tpiA PA4748Q9HV512
Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)tpiA VSAK1_12567A6D9152
Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)tpiA tpi BP0801Q7VZT52
tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaBBE932_04490 SY51_10010A0A066SS852
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ (EC 2.1.1.200) (tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase) (tRNA Cm32/Um32 methyltransferase)trmJ SSON_2614Q3YZ202
tRNA (Guanosine-2'-O-)-methyltransferase, TrmH family (EC 2.1.1.34)trmH spr1311Q8CWQ62
tRNA 2-thiocytidine biosynthesis protein TtcAttcA BX23_13370A0A028E5B42
tRNA modification GTPase MnmE (EC 3.6.-.-)mnmE trmE VSAK1_24660A6D4292
tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD)tsaD gcp EcE24377A_3528A7ZRU62
tRNA nuclease WapA (EC 3.1.-.-) (Cell wall-associated polypeptide CWBP200) (CWBP200) (RNase WapA) (Toxin WapA) (Wall-associated protein)wapA BSU39230 N17GQ078332
tRNA sulfurtransferase (EC 2.8.1.4) (Sulfur carrier protein ThiS sulfurtransferase) (Thiamine biosynthesis protein ThiI) (tRNA 4-thiouridine synthase)thiI VSAK1_08908A6D5T42
Tryptophan synthase beta chain (EC 4.2.1.20)trpB VSAK1_17077A6CUX62
Tryptophan synthase beta chain (EC 4.2.1.20)trpB VSAK1_01002A6D5682
Tryptophan synthase beta chain (EC 4.2.1.20)trpB A4T40_10575 BK334_00130 ECONIH1_07665 MS6198_14840A0A0A1A4Q42
Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)trpS PA4439Q9HVX62
Tryptophan-specific transport proteinVSAK1_05970A6CZI42
Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase)tnaA ind b3708 JW3686P0A8532
Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase)tnaA VSAK1_05975A6CZI52
Tryptophanyl-tRNA synthetasetrpS FTN_1499A0Q7Z92
Tsx proteintsx KPR_4358R4YEE42
Tungstate-binding protein TupAtupA Cj1540Q0P8852
Type 1 restriction modification system endonuclease R (EC 3.1.21.3)hsdR spr0792Q8DQ892
Type 4 fimbrial biogenesis protein PilVpilV PA4551G3XD842
Type I secretion outer membrane protein, TolC familyF911_03650 HMPREF0010_01972D0CB422
Type I site-specific restriction-modification system, M (Modification) subunit (EC 2.1.1.72)hsdM1 ACL_0589A9NFS62
Type II secretory pathway, component EpsDVSAK1_13363A6D4G42
Type IV pili secretin componentpilQ FTN_1137A0Q7082
Type IV pilus biogenesis/stability protein PilWpilF ABUW_3379A0A0D5YL782
Type IV pilus secretin PilQpilQ MXAN_5772Q1D0B42
Type IV secretion system protein PtlF (Pertussis toxin liberation protein F)ptlF BP3794Q7VSX52
Type VI secretion protein (Type VI secretion-associated protein)ACN81_17750 ERS085406_02084 ERS150876_04705A0A0E1IM912
Type-1 fimbrial protein, A chain (Type-1A pilin)fimA STM0543P379212
Tyrosine porin OpdTopdT PA2505Q9I0X72
Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS lmo1598Q8Y6T42
Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS ACL_1185A9NHF42
Ubiquinol oxidase subunit 2cyoA FTN_0195A0Q4E02
Ubiquinol--cytochrome c reductase, cytochrome c1petC PP_1319Q88N932
Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC 1.10.2.2)petA PP_1317Q88N952
Ubiquinol-cytochrome c reductase, cytochrome c1VSAK1_04845A6D9I22
Ubiquinol-cytochrome c reductase, iron-sulfur subunit (Fragment)VSAK1_04835A6D9I02
Ubiquinone biosynthesis O-methyltransferase (2-polyprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.64)ubiG PA3171Q9HZ632
UDP glucose pyrophosphorylase (EC 2.7.7.9)galU ACL_0839A9NGH32
UDP-3-O-acylglucosamine N-acyltransferase (EC 2.3.1.-)lpxD FTN_0200A0Q4E52
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferaseVSAK1_04172A6D6652
UDP-glucose dehydrogenase (EC 1.1.1.22)ugd ECRM12581_13550A0A023YZL92
UDP-glucose/GDP-mannose dehydrogenase family proteinwbtE FTN_1426A0Q7S92
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase (EC 1.1.1.335) (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid 3-dehydrogenase) (UDP-N-acetyl-D-glucosaminuronic acid 3-oxidase) (UDP-D-GlcNAcA 3-oxidase)wbpB wlbA PA3158G3XD232
UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.336) (UDP-ManNAc 6-dehydrogenase)rffD rffD_1 wecC A5958_09960 AA102_11165 ACN77_17785 ACN81_24265 ACU90_13605 AMK83_07120 AML07_07930 APZ14_08105 AUS26_16915 BE957_03170 BK251_23245 BK292_00630 BK400_21135 BMT61_13050 ERS085374_03079 ERS085379_03212 ERS139235_04174 ERS150876_04493 FORC28_6004 GJ12_23410 HW42_00430 PU06_17225 WQ89_13650 WR15_15380A0A066RF372
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (EC 2.5.1.7) (Enoylpyruvate transferase 1) (UDP-N-acetylglucosamine enolpyruvyl transferase 1) (EPT 1)murA1 murA spr1781Q8DNE82
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (EC 2.5.1.7) (Enoylpyruvate transferase 2) (UDP-N-acetylglucosamine enolpyruvyl transferase 2) (EPT 2)murA2 murZ spr0989Q8DPV42
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)murE BE932_23485 SY51_00490A0A061YL422
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)murD ACN81_28965 BE957_24760 BK248_21000 BK251_10760 BK292_13265 BK337_05410 BMT61_08290 ERS085374_01775 ERS139235_01275 GJ12_00470 HW42_04040A0A0C2EF222
Uncharacterized ABC-type transport system, periplasmic component/surface lipoproteinVSAK1_10868A6D2212
Uncharacterized lipoprotein ChiQchiQ STM0688Q8ZQX42
Uncharacterized lipoprotein YbjPybjP b0865 JW0849P758182
Uncharacterized lipoprotein YdcLydcL b1431 JW1427P644512
Uncharacterized lipoprotein YeaYyeaY b1806 JW1795P0AA912
Uncharacterized lipoprotein YedDyedD b1928 JW1913P310632
Uncharacterized lipoprotein YedDyedD STM1964Q063992
Uncharacterized lipoprotein YgdIygdI b2809 JW5448P652922
Uncharacterized lipoprotein YgdRygdR b2833 JW2801P652942
Uncharacterized lipoprotein YgeRygeR b2865 JW2833Q467982
Uncharacterized lipoprotein YifLyifL b4558 JW3781P0ADN62
Uncharacterized periplasmic proteinyiiO SSON_4083Q3YV642
Uncharacterized proteinNMB1047Q9JZH62
Uncharacterized proteinNMB1620Q9JYE32
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