EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Virulence membrane protein PagCpagC STM1246P239882
Vitamin B12 transporter BtuB (Cobalamin receptor) (Outer membrane cobalamin translocator)btuB STM4130P374092
Vitamin B12 transporter BtuB (Cobalamin receptor) (Outer membrane cobalamin translocator)btuB KPR_0214R4Y4322
Vitamin B12 transporter BtuB (Cobalamin receptor) (Outer membrane cobalamin translocator)btuB SSON_4139Q3YV102
Vitamin B12-binding proteinbtuF VSAK1_13947A6D3L52
YbaY proteinybaY KPR_4074R4YCW82
Ybl124ybl124 ACN81_23355 BE963_13215 EL75_4913 EL79_5274 EL80_5394 ERS085365_04922 ERS085406_05005A0A061K9G82
YceI family proteinVSAK1_22044A6D6L72
YfaZ proteinyfaZ KPR_0848R4Y5J62
YgiB proteinygiBQ9F5152
Zinc ABC transporter, periplasmic zinc-binding proteinVSAK1_08978A6D5U82
Zinc ABC transporter, periplasmic-binding protein ZnuAznuA ECRM12581_11685A0A023YY322
Zinc carboxypeptidase, putativePG_0232F5HE642
Zinc metalloprotease ZmpB (EC 3.4.24.-)zmpB spr0581Q8DQN52
Zn-dependent protease with chaperone functionVSAK1_24049A6D1L92
(2Fe-2S)-binding domain proteinNSU_3587G6EGW61
(P)ppGpp synthetaserelA SPy_1981Q99XX31
(P)ppGpp synthetase (EC 2.7.6.5)KU39_985A0A0K2L1Y61
(Putative) drug resistance ATPase-1 (Drug RA1) family proteinFTN_1762A0Q8P71
(R)-2-hydroxyisocaproyl-CoA dehydratase beta subunit (EC 4.2.1.157)hadC fldC_1 hgdB lcdB BN1095_530008 BN1096_180049 BN1097_160051 CD630DERM_03980 ERS445050_03309 PCZ31_0397Q5U9231
1,4-alpha-glucan branching enzyme (EC 2.4.1.18)MXAN_5360Q1D1G31
1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen branching enzyme) (BE)glgB FTN_0513A0Q5931
1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen branching enzyme) (BE)glgB SPD_1005Q04KG81
1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen branching enzyme) (BE)glgB SSON_3672Q3YW931
1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen branching enzyme) (BE)glgB VSAK1_20209A6CWX21
1,4-dihydroxy-2-naphthoate octaprenyltransferaseLMRG_02180A0A0H3GFD61
1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74)menA VSAK1_09518A6D0E41
1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36)menB Rv0548cP9WNP51
1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36)menB BSU30800P239661
1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36)menB SAOUHSC_00985Q2FZL51
1,4-dihydroxy-6-naphtoate synthase (EC 4.1.-.-) (Menaquinone biosynthetic enzyme MqnD)mqnD Cj1674Q0P7V51
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)hisA VSAK1_00210A6D5K51
1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)CPC_1656B1BN881
1-acyl-sn-glycerol-3-phosphate acyltransferases domain protein (EC 2.3.1.51)SAOUHSC_01837Q2FXJ71
1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)dxs PA4044Q9KGU71
1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)dxs yqiE BSU24270P545231
1-phosphofructokinase (EC 2.7.1.56) (Fructose 1-phosphate kinase)fruK SF2253 S2382P0AEX21
1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.2.1.88) (L-glutamate gamma-semialdehyde dehydrogenase)rocA SAOUHSC_02869Q2FV671
10 kDa chaperonin (10 kDa antigen) (BCG-A heat shock protein) (GroES protein) (Protein Cpn10)groS cpn10 groES mopB Rv3418c MTCY78.11P9WPE51
10 kDa chaperonin (Fragment)hspAQ6A0P81
10 kDa chaperonin (GroES protein) (Protein Cpn10)groS groES NMB1973Q9JXM41
10 kDa chaperonin (GroES protein) (Protein Cpn10)groS groES mopB YPO0350 y0608 YP_0505Q8ZIY41
10 kDa chaperonin (GroES protein) (Protein Cpn10)groS groES mopB b4142 JW4102P0A6F91
10 kDa chaperonin (GroES protein) (Protein Cpn10)groS groES SSON_4325Q3YUJ81
10 kDa chaperonin (GroES protein) (Protein Cpn10)groS groES SPy_2072 M5005_Spy1762P637701
10 kDa chaperonin (GroES protein) (Protein Cpn10)mopB groES groS SCH_4208Q57GP81
10 kDa chaperonin (GroES protein) (Protein Cpn10)groS groES FTT_1695Q5NEE21
102 kbases unstable region: from 1 to 119443 (Putative exported protein)YPO1942Q9ZC521
16S rRNA (cytosine(967)-C(5))-methyltransferase (EC 2.1.1.176)SAOUHSC_01184Q2FZ671
17 kDa surface antigenB195_11011M5QGP21
17 kDa surface antigenB195_01875M5QQ301
2', 3'-cyclic nucleotide 2'-phosphodiesterase (EC 3.1.3.5) (EC 3.6.1.45)OOM_1276I2AZU81
2',3'-CYCLIC-NUCLEOTIDE 2'-PHOSPHODIESTERASEcpdB jhp_0096Q9ZMW91
2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16)cpdB HPSD74_1414U4SI181
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase)dapD B195_05950M5QK641
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase)dapD STM0213Q8ZRP41
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase)dapD YPO1041 y3140 YP_2810Q8ZH691
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase)dapD b0166 JW0161P0A9D81
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase)dapD VSAK1_08576A6D0981
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)gpmA STM0772Q8ZQS21
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)gpmA YPO1133 y3048 YP_1025Q8ZGY51
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)gpmA gpm pgm pgmA b0755 JW0738P627071
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)gpmA SSON_0707Q3Z4551
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)gpmA SPy_1429 M5005_Spy1164Q99Z291
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12)gpmI Fphi_0172B0TYM81
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12)gpmI FTN_0648A0Q5M61
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12)gpmI CPF_1508Q0TQY91
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12)gpmI pgm PA5131Q9HU531
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12)gpmI VSAK1_12617A6D9251
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12)gpmI FTT_1329Q5NFB11
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12) (Vegetative protein 107) (VEG107)gpmI pgm BSU33910P397731
2,5-diketo-D-gluconic acid reductase A (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (EC 1.1.1.274) (AKR5C)dkgA yqhE b3012 JW5499Q468571
2-alkenal reductaseOOM_1695I2B0V91
2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase)kbl Fphi_0216B0TYR71
2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase)kbl FTN_0626A0Q5K41
2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase)kbl YPO0059Q0WKN31
2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase)kbl b3617 JW3592P0AB771
2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase)kbl SCH_3632Q57IC41
2-aminoethylphosphonate--pyruvate transaminase (EC 2.6.1.37) (2-aminoethylphosphonate aminotransferase) (AEP transaminase) (AEPT)phnW VSAK1_17767A6CVB41
2-aminomuconate deaminase (EC 3.5.99.5)MXAN_0920Q1DDU21
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT)ispD VSAK1_04965A6D3161
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) (2-deoxy-D-gluconate 3-dehydrogenase) (2-keto-3-deoxygluconate 5-dehydrogenase) (2-keto-3-deoxygluconate oxidoreductase) (KDG oxidoreductase) (20-ketosteroid reductase) (EC 1.1.1.-)kduD ygeC yqeD b2842 JW2810P377691
2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase)kdsA B195_18116M5QV681
2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase)kdsA YPO2021 y2286 YP_1869Q8ZEX41
2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase)kdsA PA3636Q9ZFK41
2-heptyl-3-hydroxy-4(1H)-quinolone synthase (EC 1.14.13.182) (2-heptyl-3,4-dihydroxyquinoline synthase)pqsH PA2587Q9I0Q01
2-hydroxy-3-oxopropionate reductaseB195_06810M5QKP91
2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) (Tartronate semialdehyde reductase) (TSAR)garR yhaE b3125 JW5526P0ABQ21
2-hydroxyacid dehydrogenaseB195_05286M5QYW41
2-hydroxyacid dehydrogenaseKW89_1951A0A0K2DY181
2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Enamine/imine deaminase)ridA yjgF b4243 JW5755P0AF931
2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase)leuA VSAK1_07754A6D7A51
2-keto-3-deoxygluconate permease (KDG permease)kdgT b3909 JW5560P0A7121
2-methylisocitrate lyase (2-MIC) (MICL) (EC 4.1.3.30) ((2R,3S)-2-methylisocitrate lyase)prpB B195_10161M5QG691
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (EC 1.14.13.-) (5-demethoxyubiquinone hydroxylase) (DMQ hydroxylase)coq7 B195_13775M5QX171
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (EC 1.14.13.-) (5-demethoxyubiquinone hydroxylase) (DMQ hydroxylase)coq7 OOM_1757I2B1131
2-oxoglutarate decarboxylase, component of the 2-oxoglutarate dehydrogenase complex (E1) (EC 1.2.4.2)sucA ABAYE0780B0VEH21
2-oxoglutarate dehydrogenasesucA SFV_0610Q0T6W41
2-oxoglutarate dehydrogenase (Decarboxylase component)sucA SCH_0740Q57RL51
2-oxoglutarate dehydrogenase (EC 1.2.4.2)KW89_2660A0A0K2E0251
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