EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfkA Rv3010c MTV012.24cP9WID71
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfkA SC1083_1801G4AAC81
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfkA pfk SPy_1283 M5005_Spy0989Q99ZD01
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfkA CD630_33950Q180P41
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfkA SAOUHSC_01807Q2FXM81
ATP-dependent 6-phosphofructokinase isozyme 1 (ATP-PFK 1) (Phosphofructokinase 1) (EC 2.7.1.11) (6-phosphofructokinase isozyme I) (Phosphohexokinase 1)pfkA SF3994 S3753P0A7981
ATP-dependent 6-phosphofructokinase isozyme 1 (ATP-PFK 1) (Phosphofructokinase 1) (EC 2.7.1.11) (6-phosphofructokinase isozyme I) (Phosphohexokinase 1)pfkA b3916 JW3887P0A7961
ATP-dependent chaperone ClpBSC1083_1135G4A8I41
ATP-dependent Clp protease ATP-binding subunit ClpAclpA lopD b0882 JW0866P0ABH91
ATP-dependent Clp protease ATP-binding subunit ClpXclpX lmo1268Q8Y7K91
ATP-dependent Clp protease ATP-binding subunit ClpXclpX Cj0275Q9PIM01
ATP-dependent Clp protease ATP-binding subunit ClpXclpX SPG_1495B5E6L21
ATP-dependent Clp protease ATP-binding subunit ClpXclpX SPy_0885 M5005_Spy0691P637931
ATP-dependent Clp protease ATP-binding subunit ClpXclpX SAOUHSC_01778Q2FXQ71
ATP-dependent Clp protease proteolytic subunitPP_3045Q88IF41
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP Fphi_1532B0TZA51
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP NMB1312Q9JZ381
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP B195_07515M5QMP91
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP YPO3157 y1027 YP_0774Q8ZC651
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP SPy_0395 M5005_Spy0328P698841
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP1 clpP CD630_33050Q180F01
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP Cj0192cP544131
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP FTT_0624Q5NH471
ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1)clpP1 clpP Rv2461c MTV008.17cP9WPC51
ATP-dependent Clp protease proteolytic subunit 2 (EC 3.4.21.92) (Endopeptidase Clp 2)clpP2 Rv2460c MTV008.16cP9WPC31
ATP-dependent dethiobiotin synthetase BioD (EC 6.3.3.3) (DTB synthetase) (DTBS) (Dethiobiotin synthase)bioD Fphi_1803B0U0S61
ATP-dependent DNA helicase (EC 3.6.4.12)pcrA SPy_1267Q99ZE11
ATP-dependent DNA helicase PcrA (EC 3.6.4.12)pcrA MW1846Q8NVT11
ATP-dependent DNA helicase RecG (EC 3.6.4.12)recG spr1539Q7ZAK61
ATP-dependent DNA helicase RecG (EC 3.6.4.12)recG ylpB BSU15870O349421
ATP-dependent DNA helicase RecG (EC 3.6.4.12)recG SPy_1785Q99YB01
ATP-dependent DNA helicase Rep (EC 3.6.4.12)rep PA5296Q9HTQ81
ATP-dependent DNA helicase Rep (EC 3.6.4.12)rep Smlt0095B2FU541
ATP-dependent helicase/deoxyribonuclease subunit B (EC 3.1.-.-) (EC 3.6.4.12) (ATP-dependent helicase/nuclease RexB)rexB SPy_0776 M5005_Spy0594Q9A0H41
ATP-dependent helicase/nuclease subunit A (EC 3.1.-.-) (EC 3.6.4.12) (ATP-dependent helicase/nuclease AddA)addA rexA spr1040Q8DPR61
ATP-dependent helicase/nuclease subunit A (EC 3.1.-.-) (EC 3.6.4.12) (ATP-dependent helicase/nuclease AddA)addA rexA SPy_0777 M5005_Spy0595Q9A0H31
ATP-dependent protease ATP-binding subunitclpL spr0307Q8DR681
ATP-dependent protease ATP-binding subunit-like protein AmiBamiB PA3365Q514161
ATP-dependent protease ATPase subunit HslU (Heat shock protein HslU) (Unfoldase HslU)hslU htpI b3931 JW3902P0A6H51
ATP-dependent protease ATPase subunit HslU (Heat shock protein HslU) (Unfoldase HslU)hslU htpI SF4009 S3738P0A6H71
ATP-dependent protease ATPase subunit HslU (Heat shock protein HslU) (Unfoldase HslU)hslU SCH_3980Q57HC61
ATP-dependent protease ATPase subunit HslU (Unfoldase HslU)hslU B195_02573M5QME01
ATP-dependent protease ATPase subunit HslU (Unfoldase HslU)hslU SC1083_2010G4AAY01
ATP-dependent protease ATPase subunit HslU (Unfoldase HslU)hslU OOM_1378I2B0341
ATP-dependent protease ATPase subunit HslU (Unfoldase HslU)hslU SAOUHSC_01226Q2FZ281
ATP-dependent protease subunit HslV (EC 3.4.25.2)Fphi_1592B0TZG31
ATP-dependent protease subunit HslV (EC 3.4.25.2)hslV FTN_0995A0Q6L81
ATP-dependent protease subunit HslV (EC 3.4.25.2)OOM_1379I2B0351
ATP-dependent protease subunit HslV (EC 3.4.25.2) (Heat shock protein HslV)hslV STM4092P0A2711
ATP-dependent protease subunit HslV (EC 3.4.25.2) (Heat shock protein HslV)hslV SSON_4101Q3YV461
ATP-dependent RecD-like DNA helicase (EC 3.6.4.12)recD2 SPy_1844Q99Y681
ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A)deaD SC1083_1698G4AA251
ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A)deaD HPSD74_0569U4SMS41
ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A)deaD OOM_1434I2B0871
ATP-dependent RNA helicase RhlB (EC 3.6.4.13)rhlB XCC3776Q8P4D41
ATP-dependent RNA helicase RhlE (EC 3.6.4.13)rhlE B195_14530M5QGF21
ATP-dependent RNA helicase SrmB (EC 3.6.4.13)srmB VSAK1_11228A6D8U61
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)hflB ftsH KPN_03588A6TEJ71
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)hflB ftsH FTN_0668A0Q5P51
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH AC1_0727B1RB721
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH CJD_3111B1V4Q41
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH PP_4718Q88DV11
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH OOM_1255I2AZS91
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH SCH_3234Q57JH21
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH SAOUHSC_00486Q2G0R01
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)hflB ftsH FTT_1310cQ5NFC91
ATPase involved in DNA repairVSAK1_00025A6D9961
ATPase proteindppE SPy_2004Q99XV61
ATPase proteindppD SPy_2003Q99XV71
ATPase RavA (EC 3.6.3.-) (Regulatory ATPase variant A)ravA SFV_3772Q0SYT01
Attachment invasion locus proteinail YPO2190Q7CIM91
Autoinducer 2-binding protein LsrB (AI-2-binding protein LsrB)lsrB STM4077Q8ZKQ11
Autoinducer 2-binding protein LsrB (AI-2-binding protein LsrB)lsrB YPO0409 y3772 YP_3772Q74PW21
Autoinducer-2 kinase (AI-2 kinase) (EC 2.7.1.189)lsrK KPN78578_34800 KPN_03509A6TEC01
Autonomous glycyl radical cofactorgrcA YPO2705 y1282 YP_2509Q8ZD841
Autonomous glycyl radical cofactorgrcA SF2641 S2814Q83K211
Autonomous glycyl radical cofactorgrcA yfiD b2579 JW2563P680661
Autotransporter beta-domain proteinKW89_1540A0A0K2DWX01
Autotransporter beta-domain-containing proteinNSU_3585G6EGW41
AzurinB195_03218M5R3N01
AzurinVSAK1_23824A6D1H41
B12 family TonB-dependent receptorB195_13326M5QK761
B12-dependent methionine synthase (EC 2.1.1.13)metH VSAK1_04630A6D9611
Bacitracin ABC transporter, ATP-binding proteinAC3_1318B1BVB61
Bacterial extracellular solute-binding proteinCPC_2328B1BID81
Bacterial extracellular solute-binding proteinAC1_0394B1R4B51
Bacterial extracellular solute-binding s, 3 family proteinKW89_1094A0A0K2DVN01
Bacterial extracellular solute-binding s, 3 family proteinKW89_2692A0A0K2E0P71
Bacterial extracellular solute-binding s, 5 Middle family proteinHPSD74_1574U4SHH01
Bacterial lipid A biosynthesis acyltransferase family proteinKW89_746A0A0K2DV401
Bacterial non-heme ferritin (EC 1.16.3.2)ftnA SAOUHSC_02108Q2FWZ81
Bacterial non-heme ferritin (EC 1.16.3.2) (Ferritin-1)ftnA SF1951 S2044P0A9A11
Bacterial phosphonate metabolism proteinVSAK1_19814A6CWP31
Bacterial regulatory s, luxR family proteinKW89_2118A0A0K2DZ101
Bacterial type II and III secretion system proteinFSU_0658C9RKD21
Bacteriocin transport accessory proteinLMRG_01050A0A0H3GLF81
Bacterioferritinbfr FTN_1410A0Q7R51
Bacterioferritin (EC 1.16.3.1)bfrA ACIAD0852Q6FDV61
Bacterioferritin (EC 1.16.3.1)B195_11186M5QGS91
Bacterioferritin (EC 1.16.3.1)B195_13456M5QW371
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