EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Cytokinin riboside 5'-monophosphate phosphoribohydrolase (EC 3.2.2.n1)Fphi_1459B0TYT81
Cytokinin riboside 5'-monophosphate phosphoribohydrolase (EC 3.2.2.n1)FTN_1229A0Q7951
Cytoplasmic membrane proteinlemA spr1163Q8DPH41
Cytosine deaminasecodA PA0437Q9I6801
Cytosine deaminase (EC 3.5.4.1)VSAK1_17107A6CUY21
Cytosine-specific methyltransferase (EC 2.1.1.37)SPCG_1339B2IQG71
Cytosine-specific methyltransferase (EC 2.1.1.37)SP70585_1071C1C7071
Cytosol aminopeptidasepepB FTN_0780A0Q6061
Cytosol non-specific dipeptidase (EC 3.4.13.18) (Aminoacyl-histidine dipeptidase) (Beta-alanyl-histidine dipeptidase) (Carnosinase) (Cysteinylglycinase) (Peptidase D) (Xaa-His dipeptidase) (X-His dipeptidase)pepD pepH b0237 JW0227P152881
Cytotoxicity-associated immunodominant antigen (120 kDa protein)cagA caiP802001
Cytotoxicity-associated immunodominant antigen (120 kDa protein) (CAG pathogenicity island protein 26)cagA cag26 cai jhp_0495Q9ZLT11
D-3-phosphoglycerate dehydrogenaseFphi_1431B0TYI01
D-3-phosphoglycerate dehydrogenaseB195_00135M5QQG71
D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399)serA BSU23070P351361
D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399)serA Rv2996c MTV012.10P9WNX31
D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase (EC 1.1.1.95) (EC 1.1.99.2)serA PP_5155Q88CM51
D-alanine aminotransferase (EC 2.6.1.21)SAOUHSC_01867Q2FXI01
D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase)ddl FTN_0161A0Q4A61
D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase)ddl ddlA SPy_1421 M5005_Spy1158Q99Z341
D-alanine--D-alanine ligase B (EC 6.3.2.4) (D-Ala-D-Ala ligase B) (D-alanylalanine synthetase B)ddlB PA4410Q9LCT61
D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13) (D-alanine-D-alanyl carrier protein ligase) (DCL) (D-alanine-activating enzyme) (DAE)dltA SPy_1312 M5005_Spy1073Q99ZA61
D-alanine--poly(phosphoribitol) ligase subunit 2 (EC 6.1.1.13) (D-alanyl carrier protein) (DCP)dltC SPy_1310 M5005_Spy1071P639591
D-alanine--poly(Phosphoribitol) ligase, subunit 1 (EC 6.1.1.13) (Peptide synthetase-like protein)dltA BTH_I2418 DR63_3356Q2SVW01
D-alanyl-D-alanine carboxypeptidasedacB PP_2098Q88L371
D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4)dacA spr0776Q8DQ991
D-alanyl-D-alanine carboxypeptidase (Penicillin binding protein) family protein (EC 3.4.16.4)dacD FTT_1029Q5NG281
D-alanyl-D-alanine carboxypeptidase (Penicillin binding protein) family protein (EC 3.4.16.4)dacB1 FTT_1039Q5NG201
D-alanyl-D-alanine carboxypeptidase (Putative sporulation-specific penicillin-binding protein) (EC 3.4.16.4)dacF1 CD630_24980Q182I41
D-alanyl-D-alanine carboxypeptidase dacA (EC 3.4.16.4)dacA HPSD74_1374U4SHN61
D-alanyl-D-alanine carboxypeptidase DacF (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein DacF) (PBP)dacF BSU23480P384221
D-alanyl-D-alanine carboxypeptidase family proteinAC1_2465B1R3591
D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6adacC SCH_0857Q57R981
D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 5dacA SCH_0666Q57RT91
D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidaseB195_07190M5QMJ31
D-alanyl-D-alanine dipeptidase (D-Ala-D-Ala dipeptidase) (EC 3.4.13.22)pdgL ddpX STM1599H9L4421
D-amino acid dehydrogenase (EC 1.4.99.-)dadA B195_00590M5R1A71
D-LACTATE DEHYDROGENASEdld jhp_1143Q9ZK041
D-lactate dehydrogenaseVSAK1_17237A6CV081
D-lactate dehydrogenase (EC 1.1.1.28)NMBB_1621E3D6411
D-lactate dehydrogenase (EC 1.1.1.28)dld NMB0997Q9JZL71
D-lactate dehydrogenase (EC 1.1.1.28)hslI YPO2329Q0WEJ21
D-lactate dehydrogenase (EC 1.1.1.28)NGK_0915B4RLA51
D-lactate dehydrogenase (EC 1.1.1.28)HPSD74_1847U4SCR41
D-lactate dehydrogenase, putative (EC 1.1.1.28)SAOUHSC_02875Q2FV621
D-methionine binding transport protein, ABC transporter, membrane and periplasmic proteinmetIQ FTT_1125Q5NFU41
D-methionine transport system permeaseLMRG_02588A0A0H3G9021
D-methionine-binding lipoprotein MetQmetQ STM0245Q8ZRN11
D-methionine-binding lipoprotein MetQmetQ YPO1071 y3106 YP_2778Q8ZH401
D-proline reductase proprotein prdA (EC 1.21.4.1)prdA CD630_32440Q17ZY91
D-proline reductase subunit gamma (EC 1.21.4.1) (Proline reductase)prdB_1 prdB_2 CDFC105_63473 IM33_17710 SAMEA3374973_02406 SAMEA3374989_01450 SAMEA3375004_02699A0A0D6FQX81
D-proline reductase subunit gamma (EC 1.21.4.1) (Proline reductase)prdB_1 prdB_2 BN1095_540013 BN1096_740070 BN1097_500026 IM33_17715 SAMEA3374973_02405 SAMEA3374989_01451 SAMEA3375004_02698 SAMEA3375059_02268A0A031WLJ61
D-ribose pyranase (EC 5.4.99.62)rbsD BSU35930P369461
D-ribose-binding periplasmic domain protein (Fragment)HPSD74_1712U4SCR71
D-serine transporter DsdXdsdX orf445 yfdA yfdD b2365 JW2362P085551
D-tagatose-1,6-bisphosphate aldolase subunit GatY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase)gatY yegF b2096 JW5343P0C8J61
D-tagatose-1,6-bisphosphate aldolase subunit GatZgatZ b2095 JW2082P0C8J81
D12 class N6 adenine-specific DNA methyltransferaseVSAK1_09108A6D7G61
DamX-related proteinVC_A0573Q9KM161
DcrHdcrHQ465831
dCTP deaminase (EC 3.5.4.13) (Deoxycytidine triphosphate deaminase)dcd B195_11116M5QYA71
dCTP deaminase (EC 3.5.4.13) (Deoxycytidine triphosphate deaminase)dcd Rv0321 MTCY63.26P9WP171
DEAD-box ATP-dependent RNA helicase CshA (EC 3.6.4.13)cshA MW2004Q7A0D21
DEAD-box ATP-dependent RNA helicase CshA (EC 3.6.4.13)cshA SAOUHSC_02316Q2FWH51
DEAD-box ATP-dependent RNA helicase CshA (EC 3.6.4.13)cshA LMRG_02289A0A0H3GAJ11
DEAD-box ATP-dependent RNA helicase CshA (EC 3.6.4.13) (Exported protein 9)cshA exp9 spr1440P0A4D81
DEAD-box ATP-dependent RNA helicase CshB (EC 3.6.4.13)rheB cshB spr0670Q8DQH11
DEAD-box ATP-dependent RNA helicase CshB (EC 3.6.4.13)cshB SPy_1659Q99YK31
DEAD-box ATP-dependent RNA helicase CshB (EC 3.6.4.13)cshB SAOUHSC_01659Q2FY151
DEAD-box ATP-dependent RNA helicase CshB (EC 3.6.4.13)cshB LMRG_00902A0A0H3GGC01
DedA family proteinMXAN_0324Q1DFH41
DedA family proteindedA1 FTT_1223Q5NFL11
Deferrochelatase/peroxidase EfeB (EC 1.11.1.-)efeB YPO1856 y2450 YP_1537Q7CI091
Degenerate transposaseSPCG_1219B2IQ471
Degenerate transposaseSPCG_1859B2ISY41
Degenerate transposase (Fusion of orf1 and orf2)spr1721Q8CWP01
Degenerate transposase (Orf1)spr0019Q8DRP41
Degenerate transposase (Orf1)spr0029Q8DRN81
Degenerate transposase (Orf1)spr0886Q8DQ221
Degenerate transposase (Orf2)spr0017Q8DRP61
Degenerate transposase (Orf2)spr0986Q8DPV71
Degenerate transposase (Orf2)spr1008 spr1676Q8CM311
Degenerate transposase (Orf2)spr1702Q8DNI31
DegV domain-containing protein spr0652spr0652Q8DQI61
DegV domain-containing protein SPy_0865/M5005_Spy0672SPy_0865 M5005_Spy0672Q9A0A61
DegV domain-containing protein SPy_1493/M5005_Spy1226SPy_1493 M5005_Spy1226P673721
DegV domain-containing protein SPy_1698/M5005_Spy1391SPy_1698 M5005_Spy1391Q99YH71
DegV domain-containing protein SPy_1936/M5005_Spy1650SPy_1936 M5005_Spy1650P673741
DegV family proteinCPC_0331B1BJW11
DegV family proteinCJD_3151B1UZY21
DegV family proteinCPC_0025B1BHY91
DehydrogenaseFTN_0964A0Q6I71
Deleted.0A3M8861
Deleted.0A3M5051
Deleted.0A3M9X21
Deleted.0A3M9D71
Deleted.0A3M9081
Deleted.0A3M8791
Deleted.0A3M9X31
Deleted.0A3M8851
Deleted.0A3M8841
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