This menu provides the list of EV mRNAs identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
Filter datasets:
  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
Maximum false positive rate (FPR): Maximum true positive rate (TPR):
  - FPR is the probability that an absent mRNA accidently have higher intensity than that mRNA.
  - TPR is the percentile of mRNA among the present mRNAs.
    Please see user manual in the contact us/help menu for detail.
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Since there are multiple primers in the microarray, the same mRNA can have several FPR and TPR values.

mRNA name UniProt accession FPR TPR Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
(FPR<0.05,TPR<0.5)
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 1.5e-7 4.0e-1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 8.5e-6 4.5e-1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 2 (SEC61A2 protein) (Sec61 alpha 2 subunit (S. cerevisiae), isoform CRA_d)Q8TC24 4.8e-6 4.6e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61619 0.0e+0 4.7e-1Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats.
J Cell Mol Med. 2010 Jun;14(6B):1605-18. doi: 10.1111/j.1582-4934.2009.00860.x. Epub 2009 Jul 24.		COG020112 / 0 / 12
Protein Sec61a2D3ZEH3 0.0e+0 2.1e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG020112 / 0 / 12
Protein Sec61a2D3ZEH3 0.0e+0 1.9e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 0.0e+0 1.4e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 2.0e-9 3.5e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 4.2e-9 3.6e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 7.3e-15 1.7e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 1.9e-3 5.0e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61619 0.0e+0 2.8e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61619 0.0e+0 2.6e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61620 0.0e+0 3.2e-1Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
J Extracell Vesicles. 2013 May 17;2. doi: 10.3402/jev.v2i0.20167. eCollection 2013.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61619 0.0e+0 3.0e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG020112 / 0 / 12
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)P61619 0.0e+0 1.8e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG020112 / 0 / 12
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