This menu provides the list of EV mRNAs identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
Filter datasets:
  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
Maximum false positive rate (FPR): Maximum true positive rate (TPR):
  - FPR is the probability that an absent mRNA accidently have higher intensity than that mRNA.
  - TPR is the percentile of mRNA among the present mRNAs.
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Since there are multiple primers in the microarray, the same mRNA can have several FPR and TPR values.

mRNA name UniProt accession FPR TPR Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
(FPR<0.05,TPR<0.5)
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Q9CQM8 0.0e+0 1.8e-2Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG213915 / 0 / 15
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Q9CQM8 0.0e+0 1.7e-2Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 3.0e-9 3.8e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 1.3e-5 4.7e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 2.9e-6 4.5e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 1.1e-5 4.7e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		COG213915 / 0 / 15
60S ribosomal protein L21P46778 0.0e+0 8.8e-2Nanostructural and transcriptomic analyses of human saliva derived exosomes.
PLoS One. 2010 Jan 5;5(1):e8577. doi: 10.1371/journal.pone.0008577.		COG213915 / 0 / 15
60S ribosomal protein L21P20280 0.0e+0 2.1e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein LOC100364827D4A4G9 0.0e+0 1.9e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1561815D3ZPH0 0.0e+0 6.7e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1561875D3ZHP4 0.0e+0 1.3e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1562601D3ZLH3 0.0e+0 3.9e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1562839D3ZMI8 0.0e+0 2.6e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1562929D3ZPV5 0.0e+0 4.1e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1565159D4A219 0.0e+0 2.4e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1566326D3ZE97 0.0e+0 2.9e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
60S ribosomal protein L21P20280 0.0e+0 3.0e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein LOC100364827D4A4G9 0.0e+0 2.0e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1561815D3ZPH0 0.0e+0 8.5e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1561875D3ZHP4 0.0e+0 1.6e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1562601D3ZLH3 0.0e+0 5.0e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1562839D3ZMI8 0.0e+0 2.7e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1562929D3ZPV5 0.0e+0 4.6e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1565159D4A219 0.0e+0 4.2e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
Protein RGD1566326D3ZE97 0.0e+0 3.8e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG213915 / 0 / 15
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Q9CQM8 0.0e+0 7.9e-2Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG213915 / 0 / 15
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Q9CQM8 0.0e+0 9.0e-2Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG213915 / 0 / 15
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Q9CQM8 0.0e+0 3.3e-2Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG213915 / 0 / 15
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Q9CQM8 0.0e+0 3.5e-2Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG213915 / 0 / 15
60S ribosomal protein L21P46778 0.0e+0 1.3e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		COG213915 / 0 / 15
60S ribosomal protein L21P46778 0.0e+0 6.5e-2Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 3.6e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 4.1e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 4.4e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 3.6e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 4.3e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 4.4e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 2.9e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 3.0e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 3.4e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)Q6IAX2 0.0e+0 3.1e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		COG213915 / 0 / 15
60S ribosomal protein L21P46778 0.0e+0 7.7e-2Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.
J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18389. eCollection 2012.		COG213915 / 0 / 15
60S ribosomal protein L21P46778 0.0e+0 8.7e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG213915 / 0 / 15
60S ribosomal protein L21P46778 0.0e+0 1.8e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG213915 / 0 / 15
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