This menu provides the list of EV mRNAs identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
Filter datasets:
  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
Maximum false positive rate (FPR): Maximum true positive rate (TPR):
  - FPR is the probability that an absent mRNA accidently have higher intensity than that mRNA.
  - TPR is the percentile of mRNA among the present mRNAs.
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Since there are multiple primers in the microarray, the same mRNA can have several FPR and TPR values.

mRNA name UniProt accession FPR TPR Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
(FPR<0.05,TPR<0.5)
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q9CRA4 1.1e-5 4.6e-1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG300017 / 0 / 17
Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like (Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like variant) (Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like, isoform CRA_b) (cDNA, FLJ93018, highly similar to Homo sapiens sterol-C5-desaturase (ERG3 delta-5-desaturase homolog,fungal)-like (SC5DL), mRNA)Q6GTM5 3.9e-6 4.6e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		COG300017 / 0 / 17
Fatty acid hydroxylase domain-containing protein 2Q96IV6 0.0e+0 9.2e-6Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		COG300017 / 0 / 17
Lathosterol oxidase (EC 1.14.21.6) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase)O75845 0.0e+0 2.5e-4Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		COG300017 / 0 / 17
Lathosterol oxidase (EC 1.14.21.6) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase)O75845 0.0e+0 5.7e-5Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 2.8e-1Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells.
BMC Genomics. 2009 Nov 25;10:556. doi: 10.1186/1471-2164-10-556.		COG300017 / 0 / 17
Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195)A0JPQ8 0.0e+0 4.4e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q9CRA4 8.0e-6 4.4e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG300017 / 0 / 17
Fatty acid 2-hydroxylase (EC 1.-.-.-) (Fatty acid alpha-hydroxylase)Q5MPP0 1.4e-6 3.6e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q9CRA4 3.0e-4 4.6e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 3.6e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		COG300017 / 0 / 17
Fatty acid hydroxylase domain-containing protein 2Q96IV6 4.9e-2 9.6e-2miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		COG300017 / 0 / 17
Fatty acid hydroxylase domain-containing protein 2Q96IV6 4.5e-2 2.0e-1miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 3.5e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 3.4e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		COG300017 / 0 / 17
Fatty acid 2-hydroxylase (EC 1.-.-.-) (Fatty acid alpha-hydroxylase)Q5MPP0 0.0e+0 7.9e-2Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
J Extracell Vesicles. 2013 May 17;2. doi: 10.3402/jev.v2i0.20167. eCollection 2013.		COG300017 / 0 / 17
Fatty acid 2-hydroxylase (EC 1.-.-.-) (Fatty acid alpha-hydroxylase)Q5MPP0 0.0e+0 9.4e-2Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
J Extracell Vesicles. 2013 May 17;2. doi: 10.3402/jev.v2i0.20167. eCollection 2013.		COG300017 / 0 / 17
Fatty acid 2-hydroxylase (EC 1.-.-.-) (Fatty acid alpha-hydroxylase)Q5MPP0 0.0e+0 3.9e-2Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
J Extracell Vesicles. 2013 May 17;2. doi: 10.3402/jev.v2i0.20167. eCollection 2013.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 4.4e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 4.1e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 3.3e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG300017 / 0 / 17
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Q15800 0.0e+0 2.6e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		COG300017 / 0 / 17
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