This menu provides the list of EV mRNAs identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
Filter datasets:
  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
Maximum false positive rate (FPR): Maximum true positive rate (TPR):
  - FPR is the probability that an absent mRNA accidently have higher intensity than that mRNA.
  - TPR is the percentile of mRNA among the present mRNAs.
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The downloaded CSV file is not exactly the same as the displayed table. Opening CSV file with Excel can impair its content.

Since there are multiple primers in the microarray, the same mRNA can have several FPR and TPR values.

mRNA name UniProt accession FPR TPR Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
(FPR<0.05,TPR<0.5)
E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Protein inhibitor of activated STAT protein 1)O88907 1.2e-10 3.3e-1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 0.0e+0 2.7e-1Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.
Blood. 2007 Oct 1;110(7):2440-8. Epub 2007 May 29.		ENOG410XQ2E18 / 0 / 18
Zinc finger MIZ domain-containing protein 2 (PIAS-like protein Zimp7)Q8NF64 6.3e-12 3.3e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		ENOG410XQ2E18 / 0 / 18
ZMIZ1 protein (Fragment)A0JLS3 1.3e-9 3.7e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)O75925 0.0e+0 4.4e-3Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 5.5e-5 4.4e-1Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 5.5e-5 4.4e-1Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 3.9e-6Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
J Am Soc Nephrol. 2009 May;20(5):1053-67. doi: 10.1681/ASN.2008070798. Epub 2009 Apr 23.		ENOG410XQ2E18 / 0 / 18
cDNA FLJ14651 fis, clone NT2RP2002193, highly similar to Protein inhibitor of activated STAT protein 3B3KNI3 0.0e+0 4.2e-1Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells.
BMC Genomics. 2009 Nov 25;10:556. doi: 10.1186/1471-2164-10-556.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 0.0e+0 4.6e-1Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells.
BMC Genomics. 2009 Nov 25;10:556. doi: 10.1186/1471-2164-10-556.		ENOG410XQ2E18 / 0 / 18
Pias4 protein (Protein Pias4) (Protein inhibitor of activated STAT, 4)B5DFF9 0.0e+0 2.6e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS3 (EC 6.3.2.-) (KChAP) (Potassium channel-associated protein) (Protein inhibitor of activated STAT protein 3)O70260 0.0e+0 4.9e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG410XQ2E18 / 0 / 18
Pias4 protein (Protein Pias4) (Protein inhibitor of activated STAT, 4)B5DFF9 0.0e+0 4.3e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Protein inhibitor of activated STAT protein 1)O88907 0.0e+0 4.7e-1Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.
Biochem Biophys Res Commun. 2010 Aug 6;398(4):723-9. doi: 10.1016/j.bbrc.2010.07.008. Epub 2010 Jul 17.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)Q8C5D8 0.0e+0 5.0e-1Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.
Biochem Biophys Res Commun. 2010 Aug 6;398(4):723-9. doi: 10.1016/j.bbrc.2010.07.008. Epub 2010 Jul 17.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)Q8C5D8 0.0e+0 3.9e-1Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.
Biochem Biophys Res Commun. 2010 Aug 6;398(4):723-9. doi: 10.1016/j.bbrc.2010.07.008. Epub 2010 Jul 17.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS3 (EC 6.3.2.-) (Protein inhibitor of activated STAT protein 3)Q9Y6X2 0.0e+0 4.8e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG410XQ2E18 / 0 / 18
Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17)Q9ULJ6 0.0e+0 3.2e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 4.6e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 4.3e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)O75925 0.0e+0 3.0e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 0.0e+0 5.0e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 0.0e+0 4.7e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 0.0e+0Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing.
RNA Biol. 2016 Oct 28:0.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 4.1e-1Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing.
RNA Biol. 2016 Oct 28:0.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)O75925 0.0e+0 3.7e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 0.0e+0 4.2e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS3 (EC 6.3.2.-) (Protein inhibitor of activated STAT protein 3)Q9Y6X2 0.0e+0 4.3e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 4.5e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17)Q9ULJ6 0.0e+0 5.7e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)O75925 0.0e+0 2.5e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)O75928 0.0e+0 2.4e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS3 (EC 6.3.2.-) (Protein inhibitor of activated STAT protein 3)Q9Y6X2 0.0e+0 3.7e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)Q8N2W9 0.0e+0 5.2e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17)Q9ULJ6 0.0e+0 8.9e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG410XQ2E18 / 0 / 18
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