This menu provides the list of EV mRNAs identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
Filter datasets:
  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
Maximum false positive rate (FPR): Maximum true positive rate (TPR):
  - FPR is the probability that an absent mRNA accidently have higher intensity than that mRNA.
  - TPR is the percentile of mRNA among the present mRNAs.
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Since there are multiple primers in the microarray, the same mRNA can have several FPR and TPR values.

mRNA name UniProt accession FPR TPR Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
(FPR<0.05,TPR<0.5)
Cofilin-1 (Cofilin, non-muscle isoform)P18760 0.0e+0 1.9e-1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 9.1e-8 4.1e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 4.9e-7 4.3e-1Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6. doi: 10.1038/ncb1800. Epub 2008 Nov 16.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.7e-2Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats.
J Cell Mol Med. 2010 Jun;14(6B):1605-18. doi: 10.1111/j.1582-4934.2009.00860.x. Epub 2009 Jul 24.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 5.2e-2Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats.
J Cell Mol Med. 2010 Jun;14(6B):1605-18. doi: 10.1111/j.1582-4934.2009.00860.x. Epub 2009 Jul 24.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 1.5e-1Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells.
BMC Genomics. 2009 Nov 25;10:556. doi: 10.1186/1471-2164-10-556.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 1.8e-1Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells.
BMC Genomics. 2009 Nov 25;10:556. doi: 10.1186/1471-2164-10-556.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 2.5e-2Nanostructural and transcriptomic analyses of human saliva derived exosomes.
PLoS One. 2010 Jan 5;5(1):e8577. doi: 10.1371/journal.pone.0008577.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 4.2e-1Nanostructural and transcriptomic analyses of human saliva derived exosomes.
PLoS One. 2010 Jan 5;5(1):e8577. doi: 10.1371/journal.pone.0008577.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 4.4e-2Nanostructural and transcriptomic analyses of human saliva derived exosomes.
PLoS One. 2010 Jan 5;5(1):e8577. doi: 10.1371/journal.pone.0008577.		ENOG41122P524 / 0 / 24
Cofilin-1 (Cofilin, non-muscle isoform)P45592 0.0e+0 5.1e-2Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG41122P524 / 0 / 24
Cofilin-1 (Cofilin, non-muscle isoform)P45592 0.0e+0 1.2e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF) (Sid 23)Q9R0P5 0.0e+0 4.6e-1Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells.
PLoS One. 2012;7(4):e34653. doi: 10.1371/journal.pone.0034653. Epub 2012 Apr 10.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 2.6e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 1.5e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.1e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 1.9e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 2.7e-14 4.1e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 9.9e-2Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 1.9e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 1.1e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 1.4e-2 1.1e-1miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 2.9e-2 2.3e-1miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 2.2e-2 1.7e-1miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 4.3e-2 1.9e-1miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 3.3e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG41122P524 / 0 / 24
Cofilin 2 (Muscle), isoform CRA_a (Cofilin 2 (Muscle), isoform CRA_c) (Cofilin isoform) (cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNA)Q549N0 2.0e-15 4.8e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 2.9e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG41122P524 / 0 / 24
Cofilin 2 (Muscle), isoform CRA_a (Cofilin 2 (Muscle), isoform CRA_c) (Cofilin isoform) (cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNA)Q549N0 0.0e+0 4.4e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 2.1e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 8.5e-2Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.2e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.8e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 9.0e-2Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.3e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.9e-1Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 1.4e-1Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.
J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18389. eCollection 2012.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 1.0e-12 3.0e-1Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.
J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18389. eCollection 2012.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 2.5e-13 2.9e-1Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.
J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18389. eCollection 2012.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF) (Sid 23)Q9R0P5 0.0e+0 1.9e-1Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
J Extracell Vesicles. 2013 May 17;2. doi: 10.3402/jev.v2i0.20167. eCollection 2013.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF) (Sid 23)Q9R0P5 0.0e+0 4.4e-1Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
J Extracell Vesicles. 2013 May 17;2. doi: 10.3402/jev.v2i0.20167. eCollection 2013.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 2.7e-14Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing.
RNA Biol. 2016 Oct 28:0.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 0.0e+0Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing.
RNA Biol. 2016 Oct 28:0.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 4.5e-8Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing.
RNA Biol. 2016 Oct 28:0.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 2.9e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Cofilin-2 (Cofilin, muscle isoform)Q9Y281 0.0e+0 3.7e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.3e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 1.4e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 7.9e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)P23528 0.0e+0 4.2e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 7.8e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 2.9e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
Destrin (Actin-depolymerizing factor) (ADF)P60981 0.0e+0 6.5e-2The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG41122P524 / 0 / 24
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