This menu provides the list of EV mRNAs identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
Filter datasets:
  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
Maximum false positive rate (FPR): Maximum true positive rate (TPR):
  - FPR is the probability that an absent mRNA accidently have higher intensity than that mRNA.
  - TPR is the percentile of mRNA among the present mRNAs.
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Since there are multiple primers in the microarray, the same mRNA can have several FPR and TPR values.

mRNA name UniProt accession FPR TPR Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
(FPR<0.05,TPR<0.5)
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 1.2e-5 4.6e-1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)Q13541 0.0e+0 5.0e-1Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells.
BMC Genomics. 2009 Nov 25;10:556. doi: 10.1186/1471-2164-10-556.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 2.5e-1Nanostructural and transcriptomic analyses of human saliva derived exosomes.
PLoS One. 2010 Jan 5;5(1):e8577. doi: 10.1371/journal.pone.0008577.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 2.3e-1Nanostructural and transcriptomic analyses of human saliva derived exosomes.
PLoS One. 2010 Jan 5;5(1):e8577. doi: 10.1371/journal.pone.0008577.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E binding protein 2 (Eukaryotic translation initiation factor 4E binding protein 2, isoform CRA_b) (Protein Eif4ebp2)Q497A9 0.0e+0 4.9e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)Q62622 0.0e+0 1.2e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E binding protein 2 (Eukaryotic translation initiation factor 4E binding protein 2, isoform CRA_b) (Protein Eif4ebp2)Q497A9 0.0e+0 4.7e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)Q62622 0.0e+0 1.9e-1Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)Q80VV3 0.0e+0 4.6e-1Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.
Biochem Biophys Res Commun. 2010 Aug 6;398(4):723-9. doi: 10.1016/j.bbrc.2010.07.008. Epub 2010 Jul 17.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)Q80VV3 0.0e+0 4.5e-1Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.
Biochem Biophys Res Commun. 2010 Aug 6;398(4):723-9. doi: 10.1016/j.bbrc.2010.07.008. Epub 2010 Jul 17.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 9.3e-15 2.6e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 0.0e+0 1.8e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 8.9e-16 2.4e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 2.6e-6 3.7e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 5.7e-12 2.2e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)P70445 2.1e-6 3.7e-1Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.
PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 4.7e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 3.8e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 2.5e-8 4.9e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 3.0e-1Identifying mRNA, microRNA and protein profiles of melanoma exosomes.
PLoS One. 2012;7(10):e46874. doi: 10.1371/journal.pone.0046874. Epub 2012 Oct 9.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 8.6e-3 6.2e-2miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 2.7e-2 1.0e-1miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles.
Mol Ther Nucleic Acids. 2012 Feb 7;1:e10. doi: 10.1038/mtna.2011.2.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 3.5e-1First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.
Biol Cell. 2013 Jul;105(7):289-303. doi: 10.1111/boc.201200086. Epub 2013 May 4.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 8.1e-6 4.5e-1Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.
J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18389. eCollection 2012.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 2.8e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG411277916 / 0 / 16
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)Q13542 0.0e+0 1.8e-1The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma.
J Cancer. 2016 Sep 27;7(14):1960-1967. eCollection 2016.		ENOG411277916 / 0 / 16
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