EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)MAPKAPK2P491378
MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)MAPKAPK3Q166448
Mastermind-like protein 1 (Mam-1)MAML1 KIAA0200Q925858
Matrilin-4MATN4O954608
Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)MED7 ARC34 CRSP9O435138
Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET)MANF ARMET ARPP551458
Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF)MT1F PRO0376P047338
Metaxin-2 (Mitochondrial outer membrane import complex protein 2)MTX2O754318
Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS)MTRQ997078
Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)MBD2Q9UBB58
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)MSMO1 DESP4 ERG25 SC4MOLQ158008
Methyltransferase-like protein 9 (DORA reverse strand protein) (DREV) (DREV1)METTL9 DREV CGI-81Q9H1A38
Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III)MGST3O148808
Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)MCRS1 INO80Q MSP58Q96EZ88
Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region)MTFR1 CHPPR FAM54A2 KIAA0009Q153908
Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)MGME1 C20orf72 DDK1Q9BQP78
Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog)TOMM7 TOM7 TOMM07 AD-014Q9P0U18
Mitochondrial inner membrane protein (Cell proliferation-inducing gene 4/52 protein) (Mitofilin) (p87/89)IMMT HMP MINOS2 PIG4 PIG52Q168918
Mitochondrial nucleoid factor 1 (Breast cancer-associated protein SGA-81M) (Mitochondrial protein M19)MNF1 C6orf125Q9BRT28
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)MAPK9 JNK2 PRKM9 SAPK1AP459848
MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)MOB4 MOB3 MOBKL3 PHOCN PREI3 CGI-95Q9Y3A38
Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 12)ABHD12 C20orf22Q8N2K08
Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)MORF4L2 KIAA0026 MRGXQ150148
Mpv17-like protein 2MPV17L2 FKSG24Q567V28
MuskelinMKLN1Q9UL638
Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin)MYPOP P42POPQ86VE08
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)MYC BHLHE39P011068
Myotubularin-related protein 14 (EC 3.1.3.-) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy)MTMR14 C3orf29Q8NCE28
N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)CMASQ8NFW88
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)SLC9A3R1 NHERF NHERF1O147458
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)NDUFB5O436748
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit)NDUFB7P175688
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (Atrophin-1-interacting protein 5) (AIP5) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)WWP1Q9H0M08
Negative elongation factor B (NELF-B) (Cofactor of BRCA1)NELFB COBRA1 KIAA1182Q8WX928
Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G)NGRN FI58G HT020Q9NPE28
Neural Wiskott-Aldrich syndrome protein (N-WASP)WASLO004018
Neurensin-2NRSN2 C20orf98Q9GZP18
Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII)NOS3P294748
Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Locus control region-factor 1) (Nuclear factor, erythroid derived 2, like 1) (Transcription factor 11) (TCF-11) (Transcription factor HBZ17) (Transcription factor LCR-F1)NFE2L1 HBZ17 NRF1 TCF11Q144948
Nuclear protein 1 (Candidate of metastasis 1) (Protein p8)NUPR1 COM1O603568
Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1)NCOA4 ARA70 ELE1 RFGQ137728
Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15)NUTF2 NTF2P619708
Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)DDX21Q9NR308
Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1)UBTF UBF UBF1P174808
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)TPRP122708
Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)BPTF FAC1 FALZQ128308
NUT family member 2ANUTM2A FAM22A KIAA2020Q8IVF18
Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)OSBPL2 KIAA0772 ORP2Q9H1P38
Pancreatic progenitor cell differentiation and proliferation factor (Exocrine differentiation and proliferation factor)PPDPF C20orf149 EXPDFQ9H3Y88
PAXIP1-associated glutamate-rich protein 1 (PAXIP1-associated protein 1) (PTIP-associated protein 1)PAGR1 C16orf53 PA1Q9BTK68
Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)FKBP2 FKBP13P268858
Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta)PEX11BO960118
PERQ amino acid-rich with GYF domain-containing protein 2 (GRB10-interacting GYF protein 2) (Trinucleotide repeat-containing gene 15 protein)GIGYF2 KIAA0642 PERQ2 TNRC15Q6Y7W68
PHD finger protein 20-like protein 1PHF20L1 CGI-72A8MW928
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)PIK3R2O004598
Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)PTDSS1 KIAA0024 PSSAP486518
Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)PGM1P368718
Phospholipase D3 (PLD 3) (EC 3.1.4.4) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3)PLD3Q8IV088
Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)PSPHP783308
PITH domain-containing protein 1PITHD1 C1orf128 AD039 HT014 PP603Q9GZP48
Plastin-3 (T-plastin)PLS3P137978
Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003Q7Z3K38
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)BMI1 PCGF4 RNF51P352268
Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)SUZ12 CHET9 JJAZ1 KIAA0160Q150228
Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)PQBP1 NPW38 JM26O608288
Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)KCNC3Q140038
Potassium voltage-gated channel subfamily G member 2 (Cardiac potassium channel subunit) (Voltage-gated potassium channel subunit Kv6.2)KCNG2 KCNF2Q9UJ968
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)HCN2 BCNG2Q9UL518
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4HCN4Q9Y3Q48
PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127O759158
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)PITRM1 KIAA1104 MP1Q5JRX38
Probable ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE)DHX36 DDX36 KIAA1488 MLEL1 RHAUQ9H2U18
Probable dimethyladenosine transferase (EC 2.1.1.183) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)DIMT1 DIMT1L HUSSY-05Q9UNQ28
Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4)HERC4 KIAA1593Q5GLZ88
Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc)MYCBP2 KIAA0916 PAMO755928
Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein)GPR162 GRCAQ165388
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)SMARCA1 SNF2L SNF2L1P283708
Probable glutamate--tRNA ligase, mitochondrial (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)EARS2 KIAA1970Q5JPH68
Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778Q8N4908
Probable phospholipid-transporting ATPase IIA (EC 3.6.3.1) (ATPase class II type 9A)ATP9A ATPIIA KIAA0611O751108
Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)COLGALT1 GLT25D1 PSEC0241Q8NBJ58
Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV)PAQR4Q8N4S78
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)PHB2 BAP REAQ996238
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)PAAF1 WDR71Q9BRP48
Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)PSME2Q9UL468
Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)PSMB3P497208
Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)PSMB6 LMPY YP280728
Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z)PSMB7 ZQ994368
Protein ARMCX6ARMCX6Q7L4S78
Protein FAM101BFAM101BQ8N5W98
Protein FAM127A (Mammalian retrotransposon derived protein 8C)FAM127A CXX1 MAR8 MAR8C MART8A6ZKI38
Protein FAM45AFAM45AQ8TCE68
Protein FAM98AFAM98AQ8NCA58
Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)FEM1B F1AA KIAA0396Q9UK738
Protein flightless-1 homologFLII FLILQ130458
Protein Jumonji (Jumonji/ARID domain-containing protein 2)JARID2 JMJQ928338
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)PACSIN3Q9UKS68
Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)LYL1 BHLHA18P129808
Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)MTDH AEG1 LYRICQ86UE48
Protein Mpv17MPV17P392108
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