EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Histone H2A.Z (H2A/z)H2afz H2azP0C0S610
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) (HPRT B)Hprt1 HprtP0049310
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1)Mcl1P9728710
Keratinocyte-associated protein 2 (KCP-2)Krtcap2Q5RL7910
Leucine zipper protein 1 (Leucine zipper motif-containing protein)Luzp1 LuzpQ8R4U710
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2)Acp1Q9D35810
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)Brcc3 Brcc36 C6.1aP4673710
MCG5546, isoform CRA_c (Poly(A) binding protein, cytoplasmic 4) (Protein Pabpc4)Pabpc4 mCG_5546Q6PHQ910
Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Sterol-regulated luminal protease) (Subtilisin/kexin isozyme 1) (SKI-1)Mbtps1 S1p Ski1Q9WTZ210
Mortality factor 4-like protein 2 (MORF-related gene X protein) (Sid 393) (Transcription factor-like protein MRGX)Morf4l2 Kiaa0026 Sid393Q9R0Q410
Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64)MycP0110810
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a)Ndufa7Q9Z1P610
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)Npm1Q6193710
Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)Nacc1 Btbd14b Nac1Q7TSZ810
Osteopontin (2AR) (Bone sialoprotein 1) (Calcium oxalate crystal growth inhibitor protein) (Early T-lymphocyte activation 1 protein) (Minopontin) (Secreted phosphoprotein 1) (SPP-1)Spp1 Eta-1 Op Spp-1P1092310
Peroxiredoxin-4 (EC 1.11.1.15) (Antioxidant enzyme AOE372) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372)Prdx4O0880710
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)Pparg Nr1c3P3723810
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)Farsb Farsl Farslb FrsbQ9WUA210
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Transplantability-associated protein 1) (NOR1) (TRA1)Plscr1 Tra1b Tras1Q9JJ0010
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)Pabpn1 Pab2 Pabp2Q8CCS610
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]Psen1 Ad3h Psnl1P4976910
Proliferating cell nuclear antigen (PCNA) (Cyclin)PcnaP1791810
Protein Pcdh10Pcdh10E9PX2810
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)Akt1 Akt RacP3175010
RWD domain-containing protein 1 (DRG family-regulatory protein 2) (IH1)Rwdd1 Dfrp2Q9CQK710
Serine/arginine-rich splicing factor 1 (ASF/SF2) (Pre-mRNA-splicing factor SRp30a) (Splicing factor, arginine/serine-rich 1)Srsf1 Sfrs1Q6PDM210
Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu)Prkd3 PrkcnQ8K1Y210
Solute carrier family 2, facilitated glucose transporter member 4 (GT2) (Glucose transporter type 4, insulin-responsive) (GLUT-4)Slc2a4 Glut-4 Glut4P1414210
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]Sae1 Aos1 Sua1 Ubl1a1 Uble1aQ9R1T210
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)Cct2 CctbP8031410
T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5)Cct3 CctgP8031810
Toll-like receptor 2 (CD antigen CD282)Tlr2Q9QUN710
Toll-like receptor 4 (CD antigen CD284)Tlr4 LpsQ9QUK610
Transcription factor AP-1 (AH119) (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A)JunP0562710
Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA)E2f6O5491710
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71)Tfrc TrfrQ6235110
Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2)Tmed5Q9CXE710
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a)Tnfrsf1a Tnfr-1 Tnfr1P2511810
Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)HdlbpQ8VDJ310
40S ribosomal protein S28Rps28P628589
60S ribosomal protein L19Rpl19P840999
60S ribosomal protein L7Rpl7P141489
Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)Man2a2 Mana2xQ8BRK99
AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)Zfand5 Za20d2 Zfp216 Znf216O888789
ArteminArtnQ9Z0L29
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)Bcl2l1 Bcl2l BclxQ643739
Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) (c98)Bcl2l2 Bclw Kiaa0271P703459
BCL2-like 12 (Proline rich), isoform CRA_b (Protein Bcl2l12)Bcl2l12 mCG_23151Q9D3J39
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.-)]Ndst1Q3UHN99
Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3)Rcan3 Dscr1l2Q9JKK09
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2)Ctdsp2Q8BX079
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)Csnk1d HckidQ9DC289
Chromobox homolog 3 (Drosophila HP1 gamma)Cbx3Q32P009
COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (JAB1-containing signalosome subunit 7a)Cops7a Csn7aQ9CZ049
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)Cbfb Pebp2b Pebpb2Q080249
Cytochrome c oxidase subunit 7A-related protein, mitochondrial (Cytochrome c oxidase subunit VIIa-related protein) (Silica-induced gene 81 protein) (SIG-81)Cox7a2l Cox7rp Silg81Q613879
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (MCG2872, isoform CRA_a) (Probable ATP-dependent RNA helicase DDX5)Ddx5 mCG_2872Q8BTS09
DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III subunit C11) (RPC11)Polr3kQ9CQZ79
E3 ubiquitin-protein ligase rififylin (EC 6.3.2.-) (RING finger and FYVE-like domain-containing protein 1) (Fring)RfflQ6ZQM09
ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Mel-N1)Elavl2 HubQ608999
Endonuclease domain-containing 1 protein (EC 3.1.30.-)Endod1 Kiaa0830Q8C5229
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)Eif4a1 Ddx2a Eif4aP608439
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1)Etf1Q8BWY39
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Centrosomin) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (p162)Eif3a Csma Eif3 Eif3s10P231169
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)Eif3c Eif3s8Q8R1B49
Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)Hsp90aa1 Hsp86 Hsp86-1 HspcaP079019
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1) (Inhibitor of BRAF35) (iBRAF)Hmg20a IbrafQ9DC339
Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)Hint1 Hint Pkci Pkci1 Prkcnh1P703499
Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.43) (ASH1-like protein) (Absent small and homeotic disks protein 1 homolog)Ash1lQ99MY89
L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (LDH muscle subunit) (LDH-M)Ldha Ldh-1 Ldh1P061519
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (Lysosomal membrane glycoprotein type B) (LGP-B) (CD antigen CD107b)Lamp2 Lamp-2P170479
Malate dehydrogenase, mitochondrial (EC 1.1.1.37)Mdh2 Mor1P082499
MalectinMlec Kiaa0152Q6ZQI39
MCG53395 (Protein Pdp2) (Uncharacterized protein)Pdp2 4833426J09Rik mCG_53395Q504M29
Microfibrillar-associated protein 1Mfap1Q9CQU19
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)Mapk9 Jnk2 Prkm9Q9WTU69
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (Dwarfin-C) (Dwf-C) (SMAD family member 5) (SMAD 5) (Smad5) (mSmad5)Smad5 Madh5 Msmad5P974549
Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)]PaicsQ9DCL99
Neurolysin, mitochondrial (EC 3.4.24.16) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)NlnQ91YP29
Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1)Hmgn1 Hmg-14 Hmg14P186089
Nuclear receptor subfamily 5 group A member 2 (Liver receptor homolog 1) (LRH-1)Nr5a2 Lrh1P454489
Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140)Nrip1Q8CBD19
Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3)Slc25a3Q8VEM89
Polycomb group RING finger protein 5 (RING finger protein 159)Pcgf5 Rnf159Q3UK789
Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]Galnt2Q6PB939
Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47)Ddx47Q9CWX99
Protein BRICK1 (BRK1)Brk1Q91VR89
Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1)Pomt1Q8R2R19
Protein Rbm6Rbm6Q3ULB09
Protein SGT1 homolog (Ecdysoneless homolog)Ecd Hsgt1 Sgt1Q9CS749
Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)Ptp4a2 Prl2O702749
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)Reps1O549169
Ras GTPase-activating-like protein IQGAP1Iqgap1Q9JKF19
Ras-related protein Rab-28Rab28Q99KL79
Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2)Rdh14Q9ERI69
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (S6K) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)Rps6kb1Q8BSK89
S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase 10) (Esterase D) (Sid 478)Esd Es10 Sid478Q9R0P39
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16)Ppp2caP633309
Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase)Tpi1 TpiP177519
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3)Tpm3 Tpm-5 Tpm5P211079
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