EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Ubiquitin-protein ligase E3AUbe3aE9QKT19
Zinc finger homeobox protein 3Zfhx3E9QMD39
26S proteasome complex subunit DSS1 (Deleted in split hand/split foot protein 1 homolog) (Split hand/foot deleted protein 1 homolog) (Split hand/foot malformation type 1 protein homolog)Shfm1 Dss1 Shfdg1P608978
26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)Psmd13Q9WVJ28
39S ribosomal protein L13, mitochondrial (L13mt) (MRP-L13)Mrpl13Q9D1P08
39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28)Mrpl28Q9D1B98
40S ribosomal protein S17Rps17P632768
40S ribosomal protein S20Rps20P608678
40S ribosomal protein S26Rps26P628558
6.8 kDa mitochondrial proteolipidMp68P563798
60S ribosomal protein L12Rpl12P359798
Actin-related protein 3 (Actin-like protein 3)Actr3 Arp3Q99JY98
ADP-ribosylation factor 1Arf1P840788
ADP-ribosylation factor-related protein 1 (ARF-related protein 1)Arfrp1Q8BXL78
Akirin-1Akirin1 MNCb-2831Q99LF18
AP-4 complex subunit mu-1 (AP-4 adapter complex mu subunit) (Adapter-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)Ap4m1Q9JKC78
Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1)Aen Isg20l1Q9CZI98
Atlastin-3 (EC 3.6.5.-)Atl3Q91YH58
ATP-dependent RNA helicase DDX3Y (EC (D1Pas1-related sequence 1) (DEAD box protein 3, Y-chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2)Ddx3y D1Pas1-rs1 Dead2Q620958
BTB/POZ domain-containing protein KCTD5Kctd5Q8VC578
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC; Methenyltetrahydrofolate cyclohydrolase (EC; Formyltetrahydrofolate synthetase (EC]Mthfd1Q922D88
CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp)Cnot4 Not4Q8BT148
Cdc42 effector protein 4 (Binder of Rho GTPases 4)Cdc42ep4 Borg4 Cep4Q9JM968
Cell division control protein 42 homolog (G25K GTP-binding protein)Cdc42P607668
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)Cbx5 Hp1aQ616868
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)Cops3 Csn3O885438
Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor)Cdk2ap1 Cdkap1 Doc1O352078
Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L)Cox7a2 Cox7a3 Cox7alP487718
DCN1-like protein 1 (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Testis-specific protein 3)Dcun1d1 Dcun1l1 Rp42 Tes3Q9QZ738
Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]Dag1 Dag-1Q621658
E3 ubiquitin-protein ligase RNF14 (EC 6.3.2.-) (Androgen receptor-associated protein 54) (Protein Triad2) (RING finger protein 14)Rnf14 Ara54 Triad2Q9JI908
Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)Eef1a2 Eef1al StnP626318
FGFR1 oncogene partner 2 homologFgfr1op2Q9CRA98
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)Gabarapl1 Apg8l Atg8l Gec1 MNCb-0091Q8R3R88
Gelsolin (Actin-depolymerizing factor) (ADF) (Brevin)Gsn GsbP130208
General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135)Gtf2i Bap135 Diws1tQ9ESZ88
Golgi to ER traffic protein 4 homologGet4Q9D1H78
GPI ethanolamine phosphate transferase 3 (Phosphatidylinositol glycan anchor biosynthesis, class O)PigoQ562G08
GTP-binding protein SAR1a (SAR1 gene homolog A (S. cerevisiae)) (SAR1 gene homolog A (S. cerevisiae), isoform CRA_b)Sar1a Sara1 mCG_15771Q99JZ48
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)Gnb1P628748
Heterogeneous nuclear ribonucleoprotein D-likeHnrnpdl Hnrnpdl1 HnrpdlD3YTQ38
Heterogeneous nuclear ribonucleoprotein U-like protein 1Hnrnpul1 Hnrpul1Q8VDM68
Histone H4Hist1h4a; Hist1h4b H4-53; Hist1h4c H4-12; Hist1h4d; Hist1h4f; Hist1h4h; Hist1h4i; Hist1h4j; Hist1h4k; Hist1h4m; Hist2h4a Hist2h4; Hist4h4P628068
Hypoxia-inducible lipid droplet-associated protein (Hypoxia-inducible gene 2 protein)Hilpda Hig2Q9JLS08
Itsn2 proteinItsn2B2RR828
KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)Kansl2 Nsl2Q8BQR48
Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)Cd47Q617358
Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1)Mier1 Kiaa1610Q5UAK08
Methionine synthase reductase (MSR) (EC
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)Mapre1Q611668
Minor histocompatibility antigen H13 (EC 3.4.23.-) (Presenilin-like protein 3) (Signal peptide peptidase)Hm13 H13 Psl3Q9D8V08
Multiple inositol polyphosphate phosphatase 1 (EC (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)Minpp1 Mipp MNCb-1572Q9Z2L68
N-alpha-acetyltransferase 16, NatA auxiliary subunit (NMDA receptor-regulated 1-like protein) (NARG1-like protein)Naa16 Narg1l Nat2Q9DBB48
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit)Ndufa3Q9CQ918
NHP2-like protein 1 (Fertilization antigen 1) (FA-1) (High mobility group-like nuclear protein 2 homolog 1) (Sperm-specific antigen 1) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]Nhp2l1 Ssfa1Q9D0T18
Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2) (Seizure-related protein 15)Oaz2 Sez15O086088
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC (AblSH3-binding protein) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)Inppl1 Ship2Q6P5498
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC (MGpi1p) (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q)Pigq Gpi1h Mgpi1Q9QYT78
Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta)PitpnbP538118
Plectin (PCN) (PLTN) (Plectin-1) (Plectin-6)Plec Plec1Q9QXS18
Poly (ADP-ribose) polymerase family, member 1 (Poly [ADP-ribose] polymerase 1)Parp1 Adprt1 mCG_19846Q921K28
Poly(rC)-binding protein 2 (Alpha-CP2) (CTBP) (CBP) (Putative heterogeneous nuclear ribonucleoprotein X) (hnRNP X)Pcbp2 Cbp Hnrnpx HnrpxQ619908
Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1)Ptbp3 Rod1Q8BHD78
Protein BEX4 (BEX1-like protein 1) (Brain-expressed X-linked protein 4 homolog)Bex4 Bexl1Q9CWT28
Protein BptfBptfE9Q6A78
Protein BTG1 (B-cell translocation gene 1 protein)Btg1P623258
Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein ZSIG9) (Transmembrane protein 4)Cnpy2 Msap Tmem4 Zsig9Q9QXT08
Protein Jade-1 (PHD finger protein 17)Phf17 Jade1 Kiaa1807Q6ZPI08
Protein LBH (Limb bud and heart-expressed protein)LbhQ9CX608
Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)SetQ9EQU58
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)Sec61a1 Sec61aP616208
Ras association domain-containing protein 2Rassf2 Kiaa0168Q8BMS98
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Rtn4 Kiaa0886 NogoQ99P728
RING finger protein 114 (Zinc finger protein 228) (Zinc finger protein 313)Rnf114 Zfp228 Zfp313 Znf228 Znf313Q9ET268
RING finger protein 141 (Zinc finger protein 230)Rnf141 Znf230Q99MB78
RING-box protein 2 (Rbx2) (RING finger protein 7) (Sensitive to apoptosis gene protein)Rnf7 Rbx2 SagQ9WTZ18
RNA 3'-terminal phosphate cyclase-like proteinRcl1 RnacQ9JJT08
RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Fox-1 homolog Fxh) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9)Rbfox2 Fox2 Fxh Hrnbp2 Rbm9Q8BP718
RNA-binding protein 25 (RNA-binding motif protein 25)Rbm25B2RY568
SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1)Sarnp Hcc1Q9D1J38
Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)Sept2 Nedd-5 Nedd5P422088
Serine--tRNA ligase, cytoplasmic (EC (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)Sars Sars1 SersP266388
Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)Spcs1 Spc12Q9D9588
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC (Sodium pump subunit alpha-1)Atp1a1Q8VDN28
Solute carrier family 12 member 9 (Cation-chloride cotransporter-interacting protein 1) (Potassium-chloride transporter 9)Slc12a9 Cip1 Slc12a8Q99MR38
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)Sorbs1 Kiaa1296 Sh3d5Q624178
Spindlin-1 (30000 Mr metaphase complex) (SSEC P)Spin1 SpinQ611428
Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)SfpqQ8VIJ68
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Chromosome segregation protein SmcB) (Sb1.8)Smc1a Sb1.8 Smc1 Smc1l1 SmcbQ9CU628
SUMO-conjugating enzyme UBC9 (EC 6.3.2.-) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (mUBC9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)Ube2i Ubc9 Ubce2i Ubce9P632808
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h)Smarca5 Snf2hQ91ZW38
T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta-1)Cct6a Cct6 Cctz Cctz1P803178
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)Tab2 Kiaa0733 Map3k7ip2Q99K908
Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)Thrap3 Trap150Q569Z68
Transcription factor 12 (TCF-12) (Class A helix-loop-helix transcription factor ME1) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)Tcf12 Alf1 MebQ612868
Transcription factor BTF3 (RNA polymerase B transcription factor 3)Btf3Q641528
Transcription factor E2F1 (E2F-1)E2f1Q615018
Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)Ssr3Q9DCF98
Transmembrane 9 superfamily member 2Tm9sf2P580218
Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA)TbcaP484288
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