EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Quinol oxidase subunit 2 (EC 1.10.3.-) (Oxidase aa(3)-600 subunit 2) (Quinol oxidase aa3-600, subunit QoxA) (Quinol oxidase polypeptide II)qoxA BSU38170 ipa-37dP349573
Receptor family ligand-binding proteinMXAN_1262Q1DCV43
Recombinase (Recombination protein bet)AM266_24395 EL75_2097 EL79_2408A0A086V0N73
Recombination-associated protein RdgCrdgC BE932_25585 SY51_02070A0A061YF083
Regulator protein FrmRfrmR AML07_16520 APZ14_02825 ERS150876_00540A0A0F3WCZ63
Repressor protein C2CE10_2482A0A0E0V7783
Respiratory nitrate reductase alpha chainnarG PA3875G3XCX13
Response regulatorsirA BY96_17205A0A027TS783
Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]ribA ribBA spr0162Q8DRF13
Riboflavin synthase alpha chainribC PA4055Q9HWX33
Ribonuclease E (RNase E) (EC 3.1.26.12)rne FTN_1246A0Q7B23
Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1)nrdB PA1155Q9I4I23
Ribose import binding protein RbsBrbsB prlB rbsP b3751 JW3730P029253
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs prsA Cj0918cQ9PP153
Ribose-phosphate pyrophosphokinase 2 (RPPK 2) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate 2) (Phosphoribosyl diphosphate synthase 2) (Phosphoribosyl pyrophosphate synthase 2) (P-Rib-PP synthase 2) (PRPP synthase 2) (PRPPase 2)prs2 prs spr1002P652423
Ribosomal RNA large subunit methyltransferase G (EC 2.1.1.174) (23S rRNA m2G1835 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase RlmG)rlmG APU18_16900 BE932_14355 BXT93_22215 SY51_17870A0A066SX353
Ribosomal RNA large subunit methyltransferase I (EC 2.1.1.191) (23S rRNA m5C1962 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RlmI)rlmI BX51_11055A0A025CK373
Ribosome-binding ATPase YchFychF engD Z1974 ECs1708P0ABU33
Ribosome-binding ATPase YchFychF ECBD_2418A0A140NAR53
Ribosome-recycling factor (RRF) (Ribosome-releasing factor)frr PA3653O828533
Ribulose-5-phosphate reductase (Ribulose-5-P reductase) (EC 1.1.1.405) (Ribitol-5-phosphate dehydrogenase)tarJ spr1148Q8DPI33
Right origin-binding proteinrob Z5999 ECs5354P0ACI13
RNA polymerase sigma factor RpoS (Sigma S) (Sigma-38)rpoS AC789_1c30620A0A0E1LFA83
RNA polymerase sigma-54 factorBX23_10445A0A028ECH13
RNA polymerase-associated protein RapA (EC 3.6.4.-) (ATP-dependent helicase HepA)rapA hepA PA3308Q9HYT63
RNA-binding proteinA4T50_21345 BE932_29920 SY51_06270A0A066SN323
RNA-binding transcriptional accessory protein (Transcription accessory protein)BE932_15990 SY51_19490A0A061YNY03
RND efflux transporter, AcrB/AcrD/AcrF familyFTN_1610A0Q8A53
S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase alpha chain]speD EcE24377A_0122A7ZHK93
S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 2.4.99.17) (Queuosine biosynthesis protein QueA)queA EcE24377A_0435A7ZIF73
S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS)luxS EcE24377A_2970A7ZQC03
Sec-independent protein translocase protein TatAtatA PGD_00134 SK85_04164A0A024L6163
Second ferric pyoverdine receptor FpvBfpvB PA4168Q9HWL33
Septum site-determining protein DivIVA (Cell division initiation protein DivIVA) (Minicell-associated protein DivIVA)divIVA ylmJ BSU15420P710213
Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)glyA Z3827 ECs3417Q8XA553
Serine hydroxymethyltransferase 3 (SHMT 3) (Serine methylase 3) (EC 2.1.2.1)glyA2 PA4602Q9HVI73
Serine proteasesphtra spr2045Q8DMW23
Serine protease (EC 3.4.21.-)MXAN_6352Q1CYP73
Serine protease (EC 3.4.21.-)MXAN_0587Q1DER83
Serine protease (Protease DO) (EC 3.4.21.-)htrA Cj1228cQ0P9283
Serine-type D-Ala-D-Ala carboxypeptidaseFTN_0917A0Q6E03
Signal recognition particle protein (Fifty-four homolog)ffh PA3746Q9HXP83
Signal recognition particle protein (Fifty-four homolog)ffh Z3904 ECs3473P0AGD93
Signal recognition particle protein (Fifty-four homolog)ffh CE10_3044A0A0E0V8D23
Site-determining proteinminD Smlt1251B2FTA73
Skp-like proteinPP_1600Q88MH13
Sodium/proline symporter PutPputP PA0783Q9I5F53
Soluble lytic murein transglycosylaseslt FTN_0496A0Q5773
SopBsopBD9Z5543
Spermidine/putrescine ABC transporter-periplasmic subunitspuD PP_5181Q88CJ93
Starvation-inducible DNA-binding proteinLMRG_02041A0A0H3GFE03
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA FTN_1637A0Q8D03
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA PP_4191Q88FA73
Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1)sdhA Smlt1798B2FL863
Succinate dehydrogenase hydrophobic membrane anchor subunitsdhD PA1582Q9I3D63
Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1)sdhB PP_4190Q88FA83
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD Z0883 ECs0754P0AGF13
Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC PP_4186 PP4186Q88FB23
Sugar phosphataseBX52_19210A0A0E2U1H23
Sulfate ABC transportersbp-I PP_4305Q88EZ53
Superoxide dismutase (EC 1.15.1.1)LMRG_00891A0A0H3GC363
Surface protein PspASP70585_0197C1CAE63
Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40) (D-tagatose-1,6-bisphosphate aldolase) (Tagatose-bisphosphate aldolase)lacD spr1073Q8DPP23
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase (EC 2.4.1.325) (4-alpha-L-fucosyltransferase) (TDP-Fuc4NAc:lipid II Fuc4NAc transferase) (Fuc4NAc transferase)wecF rffT BE932_18215 SY51_21580A0A066T2U83
Tetratricopeptide repeat proteinMXAN_2541Q1D9B33
Thiol:disulfide interchange proteindsbA-2 NMB0294Q7DDR63
Thiol:disulfide interchange proteindsbA PP_0127Q88RK23
Thiol:disulfide interchange proteindsbA AC789_1c42430A0A0E1LES43
Thiol:disulfide interchange protein DsbAdsbA-1 NMB0278Q9K1893
Thiol:disulfide interchange protein DsbAdsbA E2348C_4167P0A4L63
Thiol:disulfide interchange protein DsbE (Cytochrome c biogenesis protein CcmG)dsbE ccmG PA1481Q9I3N13
Thioredoxin reductase (EC 1.8.1.9)BE932_28155 SY51_04550A0A066T7553
Threonine synthaseBE932_23025 SY51_00020A0A066SPL13
Toluene tolerance proteinttg2D PP_0961Q88P913
TonB-dependent receptorMXAN_6911Q1CX483
TonB-dependent receptorPP_1446Q88MX23
Toxin expression-transcriptional accessory proteintex spr0808Q8DQ793
TPR repeat-containing protein NMB0313NMB0313Q9K1653
Transaldolase (EC 2.2.1.2)tal O3O_03880K0BE103
Transaldolase 1 (EC 2.2.1.2)tal1 SSON_0009Q3Z6063
Transcription elongation factor GreA (Transcript cleavage factor GreA)greA BY96_04470A0A027U3E83
Transcription termination/antitermination protein NusGnusG spr1820Q8DNB83
Transcriptional regulatornanR ECUMN_3378B7NCN83
Transcriptional regulatornhaR SY51_00105A0A061YHB93
Transcriptional regulatory protein PhoPUMNK88_1461A0A0E0TX073
Transferrin-binding protein 1tbp1 NMB0461Q9K0U93
Transferrin-binding protein 2 (TBP-2)tbpB tbp2 NMB0460Q9K0V03
Translation initiation factor IF-2infB FTN_1660A0Q8F33
Translation initiation factor IF-2infB spr0481Q8DQV23
Trehalose-6-phosphate synthase (EC 2.4.1.15) (Osmoregulatory trehalose synthesis protein A) (UDP-glucose-glucosephosphate glucosyltransferase)otsA A4T40_14230 BK334_13095 ECONIH1_10875 MS6198_21280A0A086V2373
Tributyrin esteraseestA spr0539Q8DQR23
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ (EC 2.1.1.200) (tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase) (tRNA Cm32/Um32 methyltransferase)trmJ BY96_10455A0A027TYH43
tRNA 2-thiocytidine biosynthesis protein TtcAttcA ECS88_1488B7MM213
tRNA 2-thiocytidine biosynthesis protein TtcAttcA ECED1_1555B7MUI73
tRNA dimethylallyltransferase (EC 2.5.1.75) (Dimethylallyl diphosphate:tRNA dimethylallyltransferase) (DMAPP:tRNA dimethylallyltransferase) (DMATase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (IPTase)miaA EcE24377A_4729A7ZV403
tRNA sulfurtransferase (EC 2.8.1.4) (Sulfur carrier protein ThiS sulfurtransferase) (Thiamine biosynthesis protein ThiI) (tRNA 4-thiouridine synthase)thiI BE932_25730 SY51_02215A0A066T5U93
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase)miaB EC958_0779 UG58_01325W8ZNP13
tRNA-dihydrouridine(20/20a) synthase (EC 1.3.1.-) (EC 1.3.1.91) (U20-specific dihydrouridine synthase) (U20-specific Dus) (tRNA-dihydrouridine synthase A)dusA_2 dusA ECRM12581_25810A0A023Z6513
Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase)tnaA BX06_13805A0A028AFZ43
Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase)tnaA Z5203 ECs4645Q8XB343
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