EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Arginine N-succinyltransferase (AST) (EC 2.3.1.109) (AOST)astA BE932_04190 SY51_09710A0A066SSE24
Arginine N-succinyltransferase (AST) (EC 2.3.1.109) (AOST)astA EC55989_1915B7L6M14
Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)argS PA5051Q9HUC84
Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)argG NGO1961Q5F5G54
Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)argG PA3525Q9HY844
Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)argG AKG99_18990 AML35_13980 BHF46_07220 BK400_20145 BV389_00935 JD73_01825 UN91_15520A0A066QXY54
Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)asnS spr1397Q8CWQ44
Aspartate carbamoyltransferase (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase)pyrB NGO1877Q5F5P04
Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A)asnA spr1785Q8CWN84
Aspartokinase (EC 2.7.2.4)NGO_0956Q5F8424
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) (EC 6.3.5.-)gatB NGO0660Q5F8V04
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) (EC 6.3.5.-)gatB PA4484Q9HVT74
ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17)hisG NGO1238Q5F7E04
ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit)atpC EcE24377A_4246A7ZTU34
ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit)atpG NGO2149Q5F4Z14
ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6)atpB PA5560Q9HT144
ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b)atpF LMRG_01715A0A0H3GKH84
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD Smlt4111B2FHY84
ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD LMRG_02341A0A0H3G8Z54
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)pfkA spr0796Q8DQ854
ATP-dependent Clp protease ATP-binding subunit ClpXclpX NGO0645Q5F8W54
ATP-dependent Clp protease proteolytic subunitA4T40_12315 AML07_13055 ECONIH1_09025 FORC28_3143 GJ12_10225 UN91_14340A0A066QBK34
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp)clpP NGO0593Q5F9144
ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1)clpP1 PA1801Q9I2U14
ATP-dependent RNA helicase RhlB (EC 3.6.4.13)rhlB UN91_08885A0A0F3UWZ84
ATP-dependent RNA helicase RhlE (EC 3.6.4.13)rhlE PA0428Q9I6894
BacterioferritinNGO_0794Q5F8H94
BacterioferritinNGO_0795Q5F8H84
Bacterioferritin (EC 1.16.3.1)bfr Smlt4297B2FJU04
Basal-body rod modification protein FlgDHP_0907O255654
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]glmU BE932_17910 SY51_21280A0A061KIX84
Bifunctional protein HldE [Includes: D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase); D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-beta-D-heptose 7-phosphotransferase) (D-glycero-beta-D-manno-heptose-7-phosphate kinase)]hldE A4T40_20875 BK334_10265 ECONIH1_18145 MS6198_35300A0A0A1ACR14
Biosynthetic arginine decarboxylase (ADC) (EC 4.1.1.19)speA BV389_05245 UN91_02850A0A0F3UKU94
Butanediol dehydrogenaseNGO_0186Q5FA464
Carbamate kinase (EC 2.7.2.2)arcC PA5173P139824
Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase ammonia chain)carB NGO_0048Q5FAH24
Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase glutamine chain)carA spr1154P637344
Carbonate dehydrataseNGO_0574Q5F9304
Catalase (EC 1.11.1.6)NGO_1767Q5F6014
Cell division ATP-binding protein FtsELMRG_01741A0A0H3GJ314
Cell division coordinator CpoBcpoB PA0974G3XDB24
Cell division coordinator CpoBcpoB Smlt3702B2FRM74
Cell division initiation proteinLMRG_01169A0A0H3GDL84
Cell division proteinNGO_2002Q5F5C74
Cell division protein FtsAftsA PA4408P472034
Cell division protein FtsNNGO_1549Q5F6K24
Cell division protein FtsZftsZ NGO_1528Q5F6M34
Cell division protein FtsZftsZ Z0105 ECs0099P0A9A84
Cell division topological specificity factorminE NGO1814Q5F5V54
Cell filamentation protein FicBE932_15770 SY51_19270A0A066SVR44
Cell shape-determining protein MreC (Cell shape protein MreC)LMRG_01423A0A0H3GH534
Chaperone protein ClpBclpB NGO_1046Q5F7W94
Chaperone protein ClpBclpB HP_0264P714044
Chaperone protein ClpBclpB htpM Z3886 ECs3455P632854
Chaperone protein DnaJdnaJ NGO1901Q5F5M14
Chaperone protein DnaJdnaJ BY96_05605A0A027U3E64
Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70)dnaK NGO1429Q5F6W54
Chaperone protein HscA homologhscA NGO0829Q5F8E84
Chaperone protein YajL (DJ-1 family protein) (Oxidative-stress-resistance chaperone)yajL A4T40_05455 BK334_05775 ECONIH1_02305 MS6198_04270A0A0A1A2034
Chaperone SurA (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (EC 5.2.1.8) (Rotamase SurA)surA Smlt0820B2FPG74
Chaperone SurA (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (EC 5.2.1.8) (Rotamase SurA)surA AA102_14675 AC789_1c00560 ACN002_0054 AM270_12245 BN17_44761 GJ12_00300 WQ89_20110J7R0864
ChitinaseNGO_0358Q5F9N54
Chorismate mutaseNGO_1343Q5F7444
Chromosome segregation proteinspo0J spr2046Q8DMW14
Citrate synthasegltA NGO_0918Q5F8734
Citrate synthaseprpC PA0795Q9I5E34
Clp protease ClpBNGO_0250Q5F9Y44
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferaseNGO_1081Q5F7T94
Coat proteinBY96_13530A0A027TXK24
Cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase (EC 2.5.1.17) (Cob(I)yrinic acid a,c-diamide adenosyltransferase)BE932_02185 SY51_07805 WM48_06780A0A066SRS14
Competence protein ComENGO_1178Q5F7J74
Conserved hypothetical exported proteinSmlt1256B2FTB24
Conserved hypothetical exported proteinSmlt1774B2FL624
Conserved hypothetical exported proteinSmlt1812B2FLW54
Conserved hypothetical exported proteinSmlt3351B2FN544
Conserved hypothetical exported proteinSmlt3796B2FSE94
Conserved hypothetical exported proteinSmlt4128B2FI054
Conserved hypothetical exported proteinSmlt4642B2FP554
Coproporphyrinogen-III oxidase (EC 1.3.98.3)NGO_1580Q5F6H84
CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)pyrG EcE24377A_3084A7ZQM34
Cysteine desulfurase IscS (EC 2.8.1.7)iscS NGO0636Q5F8X44
Cysteine desulfurase IscS (EC 2.8.1.7)iscS PA3814Q9HXI84
Cysteine synthase (EC 2.5.1.47)NGO_0340Q5F9Q24
Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)cysS EcSMS35_0571B1LKE54
Cystine transporter subunit (Cystine-binding periplasmic protein)fliY ERS085374_02771 ERS150876_01541 PGD_01311 SM09_04550A0A024L2E84
Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA)cdd E2348C_2289B7UFF94
Cytochrome CNGO_1080Q5F7U04
Cytochrome CNGO_0101Q5FAC54
Cytochrome c-type biogenesis protein CycHcycH PA1483Q9I3M94
Cytochrome o ubiquinol oxidase subunit I (Cytochrome ubiquinol oxidase subunit I)BE932_25770 SY51_02255A0A066T1G84
D-alanyl-D-alanine carboxypeptidaseLMRG_01942A0A0H3GGE34
D-alanyl-D-alanine endopeptidaseNGO_0327Q5F9R44
D-glutamyl-L-m-Dpm peptidase P45LMRG_01743A0A0H3GN804
Deleted.0A3M9304
Deleted.0A3M3224
Deleted.0A3M8I74
Deleted.0A3M9H84
Deleted.0A3M7444
Deleted.0A3MAA44
Deleted.0A3M9E64
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