EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Phospholipase DDHD2 (EC 3.1.1.-) (DDHD domain-containing protein 2) (KIAA0725p) (SAM, WWE and DDHD domain-containing protein 1)DDHD2 KIAA0725 SAMWD1O948307
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41)PRPSAP2O602567
Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)LCP1 PLS2P137967
Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)PAFAH1B1 LIS1 MDCR MDS PAFAHAP430347
Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)PARP3 ADPRT3 ADPRTL3Q9Y6F17
Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP)PARP4 ADPRTL1 KIAA0177 PARPLQ9UKK37
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)PABPN1 PAB2 PABP2Q86U427
Polyamine-modulated factor 1 (PMF-1)PMF1Q6P1K27
Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)POLDIP3 KIAA1649 PDIP46Q9BY777
Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)FIG4 KIAA0274 SAC3Q925627
Potassium voltage-gated channel subfamily C member 4 (KSHIIIC) (Voltage-gated potassium channel subunit Kv3.4)KCNC4Q037217
Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)KCNQ1 KCNA8 KCNA9 KVLQT1P517877
Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)BCAS2 DAM1O759347
Pre-rRNA-processing protein TSR2 homologTSR2Q969E87
Prefoldin subunit 3 (HIBBJ46) (Von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)VBP1 PFDN3P617587
Prenylated Rab acceptor protein 1 (PRA1 family protein 1)RABAC1 PRA1 PRAF1Q9UI147
Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)RARS2 RARSLQ5T1607
Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) (Helicain)DDX31Q9H8H27
Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5)DDX59 ZNHIT5Q5T1V67
Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD)DHX40 DDX40 ARG147Q8IX187
Probable cation-transporting ATPase 13A2 (EC 3.6.3.-)ATP13A2 PARK9Q9NQ117
Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8)JMJD1C JHDM2C KIAA1380 TRIP8Q156527
Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40)EBNA1BP2 EBP2Q998487
Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)PDCD10 CCM3 TFAR15Q9BUL87
Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)PDCD5 TFAR19O147377
Proline synthase co-transcribed bacterial homolog proteinPROSCO949037
Promethin (Transmembrane protein 159)TMEM159Q96B967
Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor)PTGER1P349957
Proteasome activator complex subunit 4 (Proteasome activator PA200)PSME4 KIAA0077Q149977
Proteasome inhibitor PI31 subunit (hPI31)PSMF1Q925307
Proteasome subunit alpha type-5 (EC 3.4.25.1) (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)PSMA5P280667
Protein BEX4 (BEX1-like protein 1) (Brain-expressed X-linked protein 4) (Nerve growth factor receptor-associated protein 3)BEX4 BEXL1 NADE3Q9NWD97
Protein BRICK1 (BRK1)BRK1 C3orf10 HSPC300 MDS027Q8WUW17
Protein BTG1 (B-cell translocation gene 1 protein)BTG1P623247
Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog)BUD31 EDG2P412237
Protein CASC4 (Cancer susceptibility candidate gene 4 protein)CASC4 UNQ2573/PRO6308Q6P4E17
Protein cereblonCRBN AD-006Q96SW27
Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025Q9Y3M27
Protein cornichon homolog 2 (CNIH-2) (Cornichon family AMPA receptor auxiliary protein 2) (Cornichon-like protein)CNIH2 CNILQ6PI257
Protein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1)DBF4B ASKL1 DRF1Q8NFT67
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)P4HB ERBA2L PDI PDIA1 PO4DBP072377
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)PDIA6 ERP5 P5 TXNDC7Q150847
Protein FAM104AFAM104AQ969W37
Protein FAM131CFAM131C C1orf117Q96AQ97
Protein FAM136AFAM136AQ96C017
Protein FAM13AFAM13A FAM13A1 KIAA0914O949887
Protein FAM13B (GAP-like protein N61)FAM13B C5orf5 FAM13B1Q9NYF57
Protein FAM195AFAM195A C16orf14Q9BUT97
Protein FAM195BFAM195BC9JLW87
Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)HEXIM2 L3Q96MH27
Protein LBH (hLBH)LBHQ53QV27
Protein lin-37 homolog (Antolefinin)LIN37 MSTP064Q96GY37
Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613)NDRG2 KIAA1248 SYLDQ9UN367
Protein phosphatase 1 regulatory subunit 11 (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase inhibitor 3)PPP1R11 HCGV TCTE5O609277
Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)PPP1R15A GADD34O758077
Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)PPM1F KIAA0015 POPX2P495937
Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)RCC2 KIAA1470 TD60Q9P2587
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)S100A6 CACYP067037
Protein SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)SMG5 EST1B KIAA1089Q9UPR37
Protein SMG7 (EST1-like protein C) (SMG-7 homolog) (hSMG-7)SMG7 C1orf16 EST1C KIAA0250Q925407
Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP)SREK1IP1 P18SRP SFRS12IP1Q8N9Q27
Protein TFG (TRK-fused gene protein)TFGQ927347
Protein transport protein Sec24C (SEC24-related protein C)SEC24C KIAA0079P539927
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)PTP4A1 PRL1 PTPCAAX1Q930967
Protein Wnt-10aWNT10AQ9GZT57
Protein yippee-like 5YPEL5 CGI-127P626997
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2)TGM2P219807
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)F2R CF2R PAR1 TRP251167
Putative ataxin-7-like protein 3BATXN7L3BQ96GX27
Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like)GTPBP6 PGPLO438247
Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)NSUN5 WBSCR20 WBSCR20AQ96P117
Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10)SLC38A10 PP1744Q9HBR07
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)PYCR1P323227
R3H domain-containing protein 2R3HDM2 KIAA1002Q9Y2K57
Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17)RABEP1 RAB5EP RABPT5 RABPT5AQ152767
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (EC 1.3.99.-) (Oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1)RSAD1Q9HA927
Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783Q9UHA47
Ran GTPase-activating protein 1 (RanGAP1)RANGAP1 KIAA1835 SDP460607
Ran-binding protein 3 (RanBP3)RANBP3Q9H6Z47
Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7)RANBP9 RANBPMQ96S597
RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)RGPD1 RANBP2L6 RGP1P0DJD07
Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)RIN1Q136717
Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)RASSF7 C11orf13 HRC1Q028337
Ras GTPase-activating-like protein IQGAP1 (p195)IQGAP1 KIAA0051P469407
Ras-related protein Rab-32RAB32Q136377
Ras-related protein Rab-4ARAB4A RAB4P203387
Ras-related protein Rab-7aRAB7A RAB7P511497
RBPJ-interacting and tubulin-associated proteinRITA C12orf52 PSEC0043Q96K307
Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)RAMP1O608947
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)ERBB3 HER3P218607
Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM)FAM213A C10orf58 PAMM PRO2290 PSEC0139 UNQ611/PRO1198Q9BRX87
Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51)RMDN3 FAM82A2 FAM82C PTPIP51 hucep-10 UNQ3122/PRO10274Q96TC77
Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP)RCN2 ERC55Q142577
Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)RTN3 ASYIP NSPL2O951977
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)PDE6D PDEDO439247
Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)ARHGEF15 KIAA0915O949897
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)ROCK2 KIAA0619O751167
Rho-related BTB domain-containing protein 3 (EC 3.6.1.-)RHOBTB3 KIAA0878O949557
Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A)RNASEH2A RNASEHI RNHIAO757927
Ribonuclease P protein subunit p20 (RNaseP protein p20) (EC 3.1.26.5) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7)POP7 RPP20O758177
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