EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Protein FAM127B (Mammalian retrotransposon derived protein 8A)FAM127B CXX1B MAR8AQ9BWD39
Protein FAM25GFAM25GB3EWG69
Protein FAM43BFAM43BQ6ZT529
Protein FAM50A (Protein HXC-26) (Protein XAP-5)FAM50A DXS9928E HXC26 XAP5Q143209
Protein FAM90A1FAM90A1Q86YD79
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)FNTAP493549
Protein Hook homolog 3 (h-hook3) (hHK3)HOOK3Q86VS89
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II)PACSIN2Q9UNF09
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)PRKCI DXS1179EP417439
Protein Niban (Cell growth-inhibiting gene 39 protein) (Protein FAM129A)FAM129A C1orf24 NIBAN GIG39Q9BZQ89
Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)PPP1R7 SDS22Q154359
Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein)UXT HSPC024Q9UBK99
Pumilio domain-containing protein KIAA0020 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8)KIAA0020 XTP5Q153979
Putative golgin subfamily A member 6-like protein 10GOLGA6L10A6NI869
Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase)PDXK C21orf124 C21orf97 PKH PNK PRED79O007649
Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)LAMTOR1 C11orf59 PDRO PP7157Q6IAA89
Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240)RALGAPA1 GARNL1 KIAA0884 TULIP1Q6GYQ09
RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1)RALBP1 RLIP1 RLIP76Q153119
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 6.3.2.-) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (Ubiquitin-conjugating enzyme 7-interacting protein 3)RBCK1 C20orf18 RNF54 UBCE7IP3 XAP3 XAP4Q9BYM89
Ras suppressor protein 1 (RSP-1) (Rsu-1)RSU1 RSP1Q154049
Ras-related protein R-Ras (p23)RRASP103019
Ras-related protein Rab-1BRAB1BQ9H0U49
Ras-related protein Rab-5BRAB5BP610209
Ras-related protein Ral-BRALBP112349
Retina and anterior neural fold homeobox protein 2 (Q50-type retinal homeobox protein) (Retina and anterior neural fold homeobox-like protein 1)RAX2 QRX RAXL1Q96IS39
Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)RB1P064009
Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta)ARHGDIB GDIA2 GDID4 RAP1GN1P525669
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)ARHGAP17 RICH1 MSTP066 MSTP110Q68EM79
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)ARHGEF1Q928889
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)RRM1 RR1P239219
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)RPS6KA2 MAPKAPK1C RSK3Q153499
RING finger protein 10RNF10 KIAA0262 RIE2Q8N5U69
RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)TARBP2 TRBPQ156339
RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1)RBFOX1 A2BP A2BP1 FOX1 HRNBP1Q9NWB19
RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity)RBFOX2 FOX2 HRNBP2 RBM9 RTAO432519
RNA-binding protein 39 (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)RBM39 HCC1 RNPC2Q144989
RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)RBM8A RBM8 HSPC114 MDS014Q9Y5S99
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)FUS TLSP356379
RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)RALY HNRPCL2 P542Q9UKM99
RNA-binding protein with multiple splicing (RBP-MS) (Heart and RRM expressed sequence) (Hermes)RBPMS HERMESQ930629
RPA-interacting protein (hRIP)RPAIN RIPQ86UA69
Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)RUNX3 AML2 CBFA3 PEBP2A3Q137619
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)RUVBL2 INO80J TIP48 TIP49B CGI-46Q9Y2309
Sepiapterin reductase (SPR) (EC 1.1.1.153)SPRP352709
Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)SHMT1P348969
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)HTRA2 OMI PRSS25O434649
Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)SRSF11 SFRS11Q055199
Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)PRKD2 PKD2 HSPC187Q9BZL69
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)CDC42BPA KIAA0451Q5VT259
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)PAK4 KIAA1142O960139
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)PPP2CAP677759
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)PPP6R2 KIAA0685 PP6R2 SAPS2O751709
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)ASH2L ASH2L1Q9UBL39
Signal recognition particle 9 kDa protein (SRP9)SRP9P494589
Signal transducer and activator of transcription 6 (IL-4 Stat)STAT6P422269
Signal transducer CD24 (Small cell lung carcinoma cluster 4 antigen) (CD antigen CD24)CD24 CD24AP250639
Small EDRK-rich factor 2 (Gastric cancer-related protein VRG107) (Protein 4F5-related) (4F5rel) (h4F5rel)SERF2 FAM2CP841019
Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)SNRPD2 SNRPD1P623169
Snurportin-1 (RNA U transporter 1)SNUPN RNUT1 SPN1O951499
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)ATP1A1P050239
Sperm-associated antigen 7SPAG7O753919
Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)S1PR2 EDG5O951369
Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)SF3A1 SAP114Q154599
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)SDHB SDH SDH1P219129
SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)SUGP2 KIAA0365 SFRS14Q8IX019
Switch-associated protein 70 (SWAP-70)SWAP70 KIAA0640 HSPC321Q9UH659
Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-)VAT1Q995369
Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)SDCBP MDA9 SYCLO005609
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Renal carcinoma antigen NY-REN-15)CCT8 C21orf112 CCTQ KIAA0002P509909
Tctex1 domain-containing protein 2TCTEX1D2Q8WW359
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)TAB1 MAP3K7IP1Q157509
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.15) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog)PRDX3 AOP1P300489
Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)TXNL1 TRP32 TXL TXNLO433969
TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)TIPRLO756639
Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)TRAK2 ALS2CR3 KIAA0549O602969
Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)TCEA1 GTF2S TFIISP231939
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)TCF12 BHLHB20 HEB HTF4Q990819
Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1)TCF7 TCF1P364029
Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)JUNP054129
Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)GTF2E2 TF2E2P290849
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)PURA PUR1Q005779
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)TRA2B SFRS10P629959
Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)TACC1 KIAA1103O754109
Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)TACC2O953599
Transketolase (TK) (EC 2.2.1.1)TKTP294019
Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)EIF2B5 EIF2BEQ131449
Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO)TSNQ156319
Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)SEC62 TLOC1Q994429
Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144)TMUB1 C7orf21 DULP HOPS SB144 UNQ763/PRO1555Q9BVT89
Transmembrane protein 59 (Liver membrane-bound protein)TMEM59 C1orf8 HSPC001 UNQ169/PRO195Q9BXS49
Transmembrane protein 98 (Protein TADA1)TMEM98 UNQ536/PRO1079Q9Y2Y69
tRNA methyltransferase 112 homolog (TRM112-like protein)TRMT112 AD-001 HSPC152 HSPC170Q9UI309
Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)TPM2 TMSBP079519
Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]WARS IFI53 WRSP233819
TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R)TSC22D3 DSIPI GILZQ995769
Tubulin, alpha 2 (Tubulin, alpha 2, isoform CRA_b) (cDNA FLJ77591, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA)TUBA2 hCG_19100Q1ZYQ19
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]TNFRSF1A TNFAR TNFR1P194389
Tumor protein D52 (Protein N8)TPD52P553279
Tumor protein D54 (hD54) (Tumor protein D52-like 2)TPD52L2O433999
Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)INPP4BO153279
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