EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)TMED5 CGI-100 UNQ397/PRO733Q9Y3A634
Tubulin alpha-3E chain (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain]TUBA3EQ6PEY234
Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)ZRANB1 TRABIDQ9UGI034
Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)UBE2Z HOYS7Q9H83234
UPF0598 protein C8orf82C8orf82Q6P1X634
Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)TECR GPSN2 SC2Q9NZ0134
Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)AHCYL2 KIAA0828Q96HN233
Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)ALDH3A1 ALDH3P3083833
Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)AGR2 AG2 UNQ515/PRO1030O9599433
Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2) [Cleaved into: Proapolipoprotein C-II (ProapoC-II)]APOC2 APC2P0265533
ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)ATP5J ATP5A ATPMP1885933
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)BAG3 BISO9581733
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.17) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)NUDT2 APAH1P5058333
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)ARFGEF1 ARFGEP1 BIG1Q9Y6D633
Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1)BAZ1A ACF1 WCRF180 HSPC317Q9NRL233
Calpastatin (Calpain inhibitor) (Sperm BS-17 component)CASTP2081033
Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)CEACAM5 CEAP0673133
CB1 cannabinoid receptor-interacting protein 1 (CRIP-1)CNRIP1 C2orf32Q96F8533
Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)CCAR1 CARP1 DISQ8IX1233
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)BCHE CHE1P0627633
Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]F9P0074033
Complement factor H-related protein 1 (FHR-1) (H factor-like protein 1) (H-factor-like 1) (H36)CFHR1 CFHL CFHL1 CFHL1P CFHR1P FHR1 HFL1 HFL2Q0359133
Dedicator of cytokinesis protein 8DOCK8Q8NF5033
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)DNMT1 AIM CXXC9 DNMTP2635833
E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (RING-type E3 ubiquitin transferase KCMF1) (ZZ-type zinc finger-containing protein 1)KCMF1 FIGC ZZZ1Q9P0J733
Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)ENOPH1 MASA MSTP145Q9UHY733
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)EPHA3 ETK ETK1 HEK TYRO4P2932033
Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)EXOSC2 RRP4Q1386833
Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase 10) (Aldehyde dehydrogenase family 3 member A2) (Microsomal aldehyde dehydrogenase)ALDH3A2 ALDH10 FALDHP5164833
Fructosamine-3-kinase (EC 2.7.1.-)FN3KQ9H47933
Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)LGALS9O0018233
Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]GPHN GPH KIAA1385Q9NQX333
Glia maturation factor gamma (GMF-gamma)GMFGO6023433
HLA class I histocompatibility antigen, A-29 alpha chain (Aw-19) (MHC class I antigen A*29)HLA-A HLAAP3051233
HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)HLA-F HLA-5.4 HLAFP3051133
HLA class I histocompatibility antigen, B-40 alpha chain (Bw-60) (MHC class I antigen B*40)HLA-B HLABQ0482633
Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)IGKV3-20P1813533
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]ITGA7 UNQ406/PRO768Q1368333
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)IL6STP4018933
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)IDH3BO4383733
Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)KRT84 KRTHB4Q9NSB233
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)SPINT1 HAI1 UNQ223/PRO256O4327833
Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)PPFIA1 LIP1Q1313633
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2Q9ULK433
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (LYR motif-containing protein 6) (NADH-ubiquinone oxidoreductase B14 subunit)NDUFA6 LYRM6 NADHB14P5655633
NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)FDXR ADXRP2257033
Neural Wiskott-Aldrich syndrome protein (N-WASP)WASLO0040133
Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3)NME3Q1323233
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form]PF4 CXCL4 SCYB4P0277633
Plexin-A2 (Semaphorin receptor OCT)PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235O7505133
Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47)DDX47Q9H0S433
Probable lysosomal cobalamin transporter (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein)LMBRD1 C6orf209 NESI BM-021 CD001 MSTP044Q9NUN533
Protein piccolo (Aczonin)PCLO ACZ KIAA0559Q9Y6V033
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)SEC61A1 SEC61AP6161933
Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP)RCN2 ERC55Q1425733
Ribonuclease 4 (RNase 4) (EC 3.1.27.-)RNASE4 RNS4P3409633
Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)RPIA RPIP4924733
Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)BRIX1 BRIX BXDC2Q8TDN633
Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)SCCPDH CGI-49Q8NBX033
Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (61E3.4) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein)SMG1 ATX KIAA0421 LIPQ96Q1533
Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter)SLC12A3 NCC TSCP5501733
Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)U2AF1 U2AF35 U2AFBP FP793Q0108133
Tetratricopeptide repeat protein 1 (TPR repeat protein 1)TTC1 TPR1Q9961433
Tetratricopeptide repeat protein 38 (TPR repeat protein 38)TTC38Q5R3I433
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)TXNIP VDUP1Q9H3M733
Transportin-2 (Karyopherin beta-2b)TNPO2O1478733
TRPM8 channel-associated factor 1 (TRP channel-associated factor 1)TCAF1 FAM115A KIAA0738Q9Y4C233
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)HCKP0863133
U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K)RRP9 RNU3IP2 U355KO4381833
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)UBE2C UBCH10O0076233
Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)AQP2P4118132
Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)CDCA8 PESCRG3Q53HL232
C-Myc-binding protein (Associate of Myc 1) (AMY-1)MYCBP AMY1Q9941732
Cell growth-regulating nucleolar proteinLYAR PNAS-5Q9NX5832
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)CBX5 HP1AP4597332
CingulinCGN KIAA1319Q9P2M732
Claudin-12CLDN12P5674932
Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]F11P0395132
Collagen alpha-1(XI) chainCOL11A1 COLL6P1210732
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)CR1 C3BRP1792732
Decorin (Bone proteoglycan II) (PG-S2) (PG40)DCN SLRR1BP0758532
Dedicator of cytokinesis protein 5DOCK5Q9H7D032
Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1)DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448Q9Y39432
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)DKK3 REIC UNQ258/PRO295Q9UBP432
DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73)DNAJC9Q8WXX532
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog)STT3B SIMPQ8TCJ232
FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)FARP2 KIAA0793 PLEKHC3O9488732
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)RABGGTAQ9269632
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase)HK2P5278932
Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g)HIST1H2AD H2AFGP2067132
Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)KRT12Q9945632
Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)KRT85 KRTHB5P7838632
Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain)LAMA2 LAMMP2404332
Lethal(2) giant larvae protein homolog 2 (HGL)LLGL2Q6P1M332
Lysyl oxidase homolog 4 (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)LOXL4 LOXCQ96JB632
Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1)MBTPS1 KIAA0091 S1P SKI1Q1470332
Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)MBD3O9598332
Microfibril-associated glycoprotein 4MFAP4P5508332
Mitochondrial import inner membrane translocase subunit TIM50TIMM50 TIM50 PRO1512Q3ZCQ832
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)SMAD3 MADH3P8402232
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