EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Protein YIPF6 (YIP1 family member 6)YIPF6Q96EC827
Putative gamma-glutamyltranspeptidase 3 (GGT 3) (EC 2.3.2.2) (Gamma-glutamyltransferase 3) (Glutathione hydrolase 3) (EC 3.4.19.13) [Cleaved into: Putative gamma-glutamyltranspeptidase 3 heavy chain; Putative gamma-glutamyltranspeptidase 3 light chain]GGT3P GGT3A6NGU527
Ras-related GTP-binding protein A (Rag A) (RagA) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1)RRAGAQ7L52327
Ras-related protein Rab-33BRAB33BQ9H08227
Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAPQ9NRY427
Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6)RNASET2 RNASE6PLO0058427
Ribosome biogenesis regulatory protein homologRRS1 KIAA0112 RRRQ1505027
Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)RPF2 BXDC1Q9H7B227
RING finger and SPRY domain-containing protein 1RSPRY1 KIAA1972 UNQ328/PRO444Q96DX427
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 3.6.3.8) (Calcium pump 3)ATP2A3Q9308427
Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2)SPP2 SPP24Q1310327
Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]SLIT2 SLIL3O9481327
Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)SLC38A5 JM24 SN2 SNAT5 PP7194Q8WUX127
Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)SF1 ZFM1 ZNF162Q1563727
Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)SPON1 KIAA0762 VSGPQ9HCB627
StriatinSTRNO4381527
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B)SMARCD2 BAF60B PRO2451Q9292527
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)MAPKAP1 MIP1 SIN1Q9BPZ727
Testican-1 (Protein SPOCK)SPOCK1 SPOCK TIC1 TICN1Q0862927
Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog)TRRAP PAF400Q9Y4A527
Transmembrane 7 superfamily member 3 (Seven span transmembrane protein)TM7SF3Q9NS9327
Transmembrane protein 51TMEM51 C1orf72Q9NW9727
tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)TRMT1Q9NXH927
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)SYKP4340527
Uncharacterized protein C21orf58C21orf58P5850527
Unconventional myosin-X (Unconventional myosin-10)MYO10 KIAA0799Q9HD6727
Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)SLC7A6 KIAA0245Q9253627
Zinc finger ZZ-type and EF-hand domain-containing protein 1ZZEF1 KIAA0399O4314927
2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)PDE12Q6L8Q726
2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)OAS2P2972826
40S ribosomal protein SA (Fragment)RPSAC9J9K326
5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)OPLAHO1484126
60S acidic ribosomal protein P0-like (Large ribosomal subunit protein uL10-like)RPLP0P6Q8NHW526
Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 9)ACOT9 CGI-16Q9Y30526
Allograft inflammatory factor 1-like (Ionized calcium-binding adapter molecule 2)AIF1L C9orf58 IBA2 UNQ672/PRO1306Q9BQI026
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)AP1S2 DC22P5637726
Armadillo repeat-containing protein 8ARMC8 S863-2Q8IUR726
ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase)NAXD CARKDQ8IW4526
ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)DDX24Q9GZR726
ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)DDX42Q86XP326
ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2)DDX50Q9BQ3926
Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19)CTNNBL1 C20orf33 PP8304Q8WYA626
Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852Q9Y5Z026
Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)PPP3R1 CNA2 CNBP6309826
Calmodulin-like protein 3 (CaM-like protein) (CLP) (Calmodulin-related protein NB-1)CALML3P2748226
Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1)CHST14 D4ST1 UNQ1925/PRO4400Q8NCH026
Carboxypeptidase Q (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase)CPQ LCH1 PGCPQ9Y64626
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)CNOT7 CAF1Q9UIV126
CDKN2AIP N-terminal-like protein (CDKN2A-interacting protein N-terminal-like protein)CDKN2AIPNLQ96HQ226
Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2)CADM4 IGSF4C NECL4 TSLL2Q8NFZ826
DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)MOXD1 MOX UNQ2493/PRO5780Q6UVY626
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)DOCK11 ZIZ2Q5JSL326
DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)LIG1P1885826
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)POLR1AO9560226
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)DNM3 KIAA0820Q9UQ1626
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)RNF40 BRE1B KIAA0661O7515026
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)HERC2O9571426
E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A)TRIM32 HT2AQ1304926
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)SLC4A4 NBC NBC1 NBCE1Q9Y6R126
Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]EPX EPER EPO EPPP1167826
Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)SLC1A1 EAAC1 EAAT3P4300526
F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)TBL1XR1 IRA1 TBLR1Q9BZK726
Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)BBOX1 BBH BBOXO7593626
Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR)SNCG BCSG1 PERSYN PRSNO7607026
Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin)GNL3 E2IG3 NSQ9BVP226
HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3)HS1BP3Q53T5926
HD domain-containing protein 2 (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2)HDDC2 C6orf74 NS5ATP2 CGI-130Q7Z4H326
Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)HELZ2 KIAA1769 PRIC285Q9BYK826
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2) [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]HN1 ARM2Q9UK7626
Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)HDGFRP2 HDGF2 UNQ785/PRO1604Q7Z4V526
Histone H2B type 1-N (Histone H2B.d) (H2B/d)HIST1H2BN H2BFDQ9987726
Histone H2B type 2-FHIST2H2BFQ5QNW626
HLA class I histocompatibility antigen, B-35 alpha chain (MHC class I antigen B*35)HLA-B HLABP3068526
HLA class I histocompatibility antigen, B-57 alpha chain (Bw-57) (MHC class I antigen B*57)HLA-B HLABP1846526
HLA class I histocompatibility antigen, Cw-2 alpha chain (MHC class I antigen Cw*2)HLA-C HLACP3050126
HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)HLA-DPB1 HLA-DP1BP0444026
Immunity-related GTPase family Q proteinIRGQ IRGQ1 FKSG27Q8WZA926
Immunoglobulin kappa variable 4-1 (Ig kappa chain V-IV region B17) (Ig kappa chain V-IV region JI) (Ig kappa chain V-IV region Len) (Ig kappa chain V-IV region STH)IGKV4-1P0162526
Immunoglobulin lambda-like polypeptide 1 (CD179 antigen-like family member B) (Ig lambda-5) (Immunoglobulin omega polypeptide) (Immunoglobulin-related protein 14.1) (CD antigen CD179b)IGLL1 IGL1P1581426
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)KRIT1 CCM1O0052226
Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1)LUC7L3 CREAP1 CROP O48O9523226
Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI)MPI PMI1P3494926
Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)MED11 HSPC296Q9P08626
Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)STEAP4 STAMP2 TNFAIP9Q687X526
Metastasis-associated protein MTA1MTA1Q1333026
MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)MICALL1 KIAA1668 MIRAB13Q8N3F826
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)MAPK15 ERK7 ERK8Q8TD0826
Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)SLC16A7 MCT2O6066926
N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)CMASQ8NFW826
NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2)CYB5R1 NQO3A2 UNQ3049/PRO9865Q9UHQ926
Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)NEFH KIAA0845 NFHP1203626
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]NFKB2 LYT10Q0065326
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)SIN3AQ96ST326
Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)PNN DRS MEMAQ9H30726
Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]PDGFC SCDGF UNQ174/PRO200Q9NRA126
Pre-rRNA-processing protein TSR1 homologTSR1 KIAA1401Q2NL8226
Programmed cell death protein 2-likePDCD2LQ9BRP126
ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))]PCSK1NQ9UHG226
Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein)PDIA5 PDIRQ1455426
Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein)C9orf142 PAXX XLSQ9BUH626
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