EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)UBQLN2 N4BP4 PLIC2 HRIHFB2157Q9UHD944
Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)MYO5A MYH12Q9Y4I144
[F-actin]-methionine sulfoxide oxidase MICAL3 (EC (Molecule interacting with CasL protein 3) (MICAL-3)MICAL3 KIAA0819 KIAA1364Q7RTP644
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)PLCG1 PLC1P1917443
2-oxoglutarate dehydrogenase, mitochondrial (EC (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)OGDHQ0221843
Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC (Alkaline phosphatase liver/bone/kidney isozyme)ALPLP0518643
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V)MGAT5 GGNT5Q0932843
Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]APOC1P0265443
Butyrophilin subfamily 2 member A1BTN2A1 BT2.1 BTF1Q7KYR743
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)CTDSP1 NIF3 NLIIF SCP1Q9GZU743
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)CBFBQ1395143
Cystathionine gamma-lyase (EC (Cysteine-protein sulfhydrase) (Gamma-cystathionase)CTHP3292943
Cytochrome b5 (Microsomal cytochrome b5 type A) (MCB5)CYB5A CYB5P0016743
Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1)DPM3Q9P2X043
E3 UFM1-protein ligase 1 (EC 6.3.2.-) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1)UFL1 KIAA0776 NLBP RCADO9487443
Ethanolamine-phosphate cytidylyltransferase (EC (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase)PCYT2Q9944743
Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (Mammary-derived growth inhibitor) (MDGI) (Muscle fatty acid-binding protein) (M-FABP)FABP3 FABP11 MDGIP0541343
Fumarylacetoacetate hydrolase domain-containing protein 2A (EC 3.-.-.-)FAHD2A CGI-105Q96GK743
Glutamate--cysteine ligase catalytic subunit (EC (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)GCLC GLCL GLCLCP4850643
Glutaminyl-peptide cyclotransferase (EC (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)QPCTQ1676943
Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain)HBG1 PRO2979P6989143
Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)SAP18 GIG38O0042243
Histone H3.1t (H3/t) (H3t) (H3/g)HIST3H3 H3FTQ1669543
Immediate early response 3-interacting protein 1IER3IP1 HSPC039Q9Y5U943
Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region)IGLC2P0DOY243
Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC (IMPDH-I)IMPDH1 IMPD1P2083943
Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)IFI35 IFP35P8021743
Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)LLGL1 DLG4 HUGL HUGL1Q1533443
Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)KDM1A AOF2 KDM1 KIAA0601 LSD1O6034143
Maleylacetoacetate isomerase (MAAI) (EC (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC MAAIO4370843
Mimecan (Osteoglycin) (Osteoinductive factor) (OIF)OGN OIF SLRR3AP2077443
NAD(P) transhydrogenase, mitochondrial (EC (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)NNTQ1342343
Nucleobindin-2 (DNA-binding protein NEFA) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]NUCB2 NEFAP8030343
Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)NOLC1 KIAA0035 NS5ATP13Q1497843
Phosphoglycerate kinase 2 (EC (Phosphoglycerate kinase, testis specific)PGK2 PGKBP0720543
Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)]EGFP0113343
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)MKI67P4601343
Protein FAM98BFAM98BQ52LJ043
Protein HEG homolog 1HEG1 KIAA1237Q9ULI343
Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein)RASA3Q1464443
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC PTPKQ1526243
Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM)FAM213A C10orf58 PAMM PRO2290 PSEC0139 UNQ611/PRO1198Q9BRX843
RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1)RTCA RPC RPC1 RTC1 RTCD1O0044243
RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)RBM14 SIPQ96PK643
Sorting nexin-17SNX17 KIAA0064Q1503643
STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC (DCHT) (Serine/threonine-protein kinase 39)STK39 SPAKQ9UEW843
Transmembrane protein 106BTMEM106BQ9NUM443
Trypsin-1 (EC (Beta-trypsin) (Cationic trypsinogen) (Serine protease 1) (Trypsin I) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]PRSS1 TRP1 TRY1 TRYP1P0747743
U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140)U2SURP KIAA0332 SR140O1504243
Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72)UBTD2 DCUBP SB72Q8WUN743
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2)SLC35B2 PAPST1 PSEC0149Q8TB6142
Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)]ADGRG6 DREG GPR126 VIGRQ86SQ442
Band 4.1-like protein 5EPB41L5 KIAA1548Q9HCM442
BRISC complex subunit Abro1 (Abraxas brother protein 1) (Protein FAM175B)FAM175B ABRO1 KIAA0157Q1501842
Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein)CAB39LQ9H9S442
CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)CD70 CD27L CD27LG TNFSF7P3297042
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)CHD4Q1483942
Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)CTGF CCN2 HCS24 IGFBP8P2927942
Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)FOLR1 FOLRP1532842
Glutamine synthetase (GS) (EC (Glutamate decarboxylase) (EC (Glutamate--ammonia ligase)GLUL GLNSP1510442
HLA class I histocompatibility antigen, B-27 alpha chain (MHC class I antigen B*27)HLA-B HLABP0398942
Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)IGKV3-20P0162042
Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3)JAM3 UNQ859/PRO1868Q9BX6742
Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)KRT73 K6IRS3 KB36 KRT6IRS3Q86Y4642
Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod)KNTC1 KIAA0166P5074842
Maltase-glucoamylase, intestinal [Includes: Maltase (EC (Alpha-glucosidase); Glucoamylase (EC (Glucan 1,4-alpha-glucosidase)]MGAM MGA MGAMLO4345142
Mitochondrial-processing peptidase subunit alpha (EC (Alpha-MPP) (P-55)PMPCA INPP5E KIAA0123 MPPAQ1071342
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit)NDUFB4O9516842
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC (EC (Complex I-75kD) (CI-75kD)NDUFS1P2833142
Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)SPP1 BNSP OPN PSEC0156P1045142
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)FKBP5 AIG6 FKBP51Q1345142
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)PDGFRB PDGFR PDGFR1P0961942
Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)PAIP1Q9H07442
Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)FAT4 CDHF14 FATJ Nbla00548Q6V0I742
Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K)POTEKP ACTBL3 FKSG30Q9BYX742
Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)RAB11FIP1 RCPQ6WKZ442
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC PTPGP2347042
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)RHOV ARHV WRCH2Q96L3342
Ribosyldihydronicotinamide dehydrogenase [quinone] (EC (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)NQO2 NMOR2P1608342
Serine/threonine-protein kinase N2 (EC (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)PKN2 PRK2 PRKCL2Q1651342
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)STAM2 HBPO7588642
Spectrin beta chain, erythrocytic (Beta-I spectrin)SPTB SPTB1P1127742
Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)TRA2AQ1359542
Treacle protein (Treacher Collins syndrome protein)TCOF1Q1342842
U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)SNRNP40 PRP8BP SFP38 WDR57Q96DI742
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)LSM4Q9Y4Z042
Vacuolar protein sorting-associated protein 18 homolog (hVPS18)VPS18 KIAA1475Q9P25342
Vacuolar protein sorting-associated protein 33A (hVPS33A)VPS33AQ96AX142
Xaa-Pro aminopeptidase 2 (EC (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)XPNPEP2O4389542
Active breakpoint cluster region-related proteinABRQ1297941
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)ACTN2P3560941
Alpha-amylase 1 (EC (1,4-alpha-D-glucan glucanohydrolase 1) (Salivary alpha-amylase)AMY1A AMY1; AMY1B AMY1; AMY1C AMY1P0474541
Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)ANK1 ANKP1615741
Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2)ANTXR2 CMG2P5833541
C4b-binding protein beta chainC4BPBP2085141
Caspase-3 (CASP-3) (EC (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]CASP3 CPP32P4257441
CDGSH iron-sulfur domain-containing protein 1 (MitoNEET)CISD1 C10orf70 ZCD1 MDS029Q9NZ4541
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CFIm68) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)CPSF6 CFIM68Q1663041
Coiled-coil domain-containing protein 80 (Down-regulated by oncogenes protein 1) (Up-regulated in BRS-3 deficient mouse homolog)CCDC80 DRO1 URB HBE245Q76M9641
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