EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_a (F-actin-capping protein subunit beta)Capzb mCG_122335A2AMW05
Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3)Cbr3Q8K3545
Carboxylesterase 1D (Carboxylesterase 3) (EC 3.1.1.1) (EC 3.1.1.67) (Fatty acid ethyl ester synthase) (FAEE synthase) (Triacylglycerol hydrolase) (TGH)Ces1d Ces1 Ces3Q8VCT45
Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)Cpt2 Cpt-2P528255
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]Casp1 Il1bcP294525
CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)Cebpz Cbf2 Cebpa-rs1P535695
CCR4-NOT transcription complex subunit 10Cnot10Q8BH155
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) (CAF-1)Cnot7 Caf1Q608095
CD44 antigenCd44A2APM25
CDGSH iron-sulfur domain-containing protein 2 (MitoNEET-related 1 protein) (Miner1) (Nervous system overexpressed protein 70)Cisd2 Cdgsh2 Noxp70 Zcd2Q9CQB55
Cell division cycle 5-like protein (Cdc5-like protein)Cdc5l Kiaa0432Q6A0685
Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1)Cdca3 C8 Grcc8 Tome1Q99M545
Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c)Chmp4cQ9D7F75
Chitinase-3-like protein 1 (BRP39 protein) (Breast regression protein 39) (Cartilage glycoprotein 39) (CGP-39) (GP-39)Chi3l1 Brp39 Chil1Q613625
Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1)Chd1 Chd-1P402015
Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)Acod1 Irg1P549875
Citron Rho-interacting kinaseCitE9QL535
Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2)Cldn3 Cpetr2Q9Z0G95
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)Cpsf3 Cpsf73Q9QXK75
Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)Cstf3Q99LI75
Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain]F12Q80YC55
Coagulation factor XIII B chain (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain)F13b Cf13bQ079685
Coiled-coil domain-containing protein 80 (Up-regulated in BRS-3 deficient mouse)Ccdc80 UrbQ8R2G65
Coiled-coil domain-containing protein 88B (Gipie) (Hook-related protein 3) (HkRP3)Ccdc88b Ccdc88Q4QRL35
Complement component C8 beta chain (Complement component 8 subunit beta)C8bQ8BH355
Complement factor D (EC 3.4.21.46) (28 kDa adipocyte protein) (Adipsin) (C3 convertase activator) (Properdin factor D)Cfd Adn DfP039535
Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (Component of oligomeric Golgi complex 5)Cog5Q8C0L85
Contactin-1 (Neural cell surface protein F3)Cntn1P129605
COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)Cops7b Csn7bQ8BV135
Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin)Serpina6 CbgQ067705
Costars family protein ABRACL (ABRA C-terminal-like protein)AbraclQ4KML45
Crooked neck-like protein 1 (Crooked neck homolog)Crnkl1P631545
CSC1-like protein 2 (Transmembrane protein 63B)Tmem63bQ3TWI95
Cyclin-G-associated kinase (EC 2.7.11.1)GakQ99KY45
Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)Cdo1P603345
Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)UqcrhP990285
Cytochrome b-c1 complex subunit 7Uqcrb mCG_67985Q9CQB45
Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L)Cox7a2 Cox7a3 Cox7alP487715
Cytoplasmic dynein 1 intermediate chain 2Dync1i2A2BFF85
Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (mDHC11) (Dynein heavy chain isotype 1B)Dync2h1 Dhc1b Dnchc2 Kiaa1997Q45VK75
D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase)DdtO352155
Death domain-containing membrane protein NRADD (Neurotrophin receptor homolog-2) (NRH2) (Neurotrophin receptor-alike death domain protein)NraddQ8CJ265
Dedicator of cytokinesis protein 5 (Lens rupture protein 2) (Rupture of lens cataract protein)Dock5 Lr2 RlcB2RY045
Dedicator of cytokinesis protein 7Dock7E9PX485
Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1)Dhrs7b Sdr32c1Q99J475
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)Ech1O354595
Deoxyhypusine hydroxylase (DOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase)DohhQ99LN95
Deoxyuridine triphosphatase (Deoxyuridine triphosphatase, isoform CRA_b) (Dutp protein) (Putative uncharacterized protein)Dut Dutp mCG_6136Q8VCG15
DEP domain-containing protein 1BDepdc1bQ8BH885
DIP2 disco-interacting protein 2 homolog B (Drosophila) (Disco-interacting protein 2 homolog B)Dip2bB2RQC75
Dip2c protein (Disco-interacting protein 2 homolog C)Dip2cB7ZMZ75
Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)MvdQ99JF55
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Mitogen-responsive phosphoprotein)Dab2 Doc2P980785
Disco-interacting protein 2 homolog CDip2cE9PWR45
DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like)Ercc6lQ8BHK95
DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)Lig1 Lig-1P379135
DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-)Pold1P524315
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A)Pole Pole1Q9WVF75
DNA segment, Chr 17, human D6S56E 5, isoform CRA_c (Putative uncharacterized protein) (Viral envelope protein G7e)D17H6S56E-5 G7e mCG_15925Q91UZ65
DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Endoplasmic reticulum DnaJ-PDI fusion protein 1) (J domain-containing protein disulfide isomerase-like protein) (J domain-containing PDI-like protein) (JPDI)Dnajc10 Erdj5 JpdiQ9DC235
DnaJ homolog subfamily C member 5 (Fragment)Dnajc5A2AUE15
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2Rpn2A2ACG75
Down syndrome critical region protein 3 homolog (Down syndrome critical region protein A homolog)Dscr3 Dcra DscraO350755
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1)Map2k4 Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1P478095
Dual-specificity mitogen-activated protein kinase kinase 2 (Mitogen activated protein kinase kinase 2, isoform CRA_d) (Mitogen-activated protein kinase kinase 2) (Putative uncharacterized protein)Map2k2 mCG_142349Q91YS75
Dynactin subunit 1Dctn1E9Q5865
Dynamin-2 (Putative uncharacterized protein)Dnm2Q3T9X35
Dynamin-3 (EC 3.6.5.5)Dnm3 Kiaa0820Q8BZ985
Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Large GTP-binding protein) (LargeG) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like 120 kDa protein, form S1]Opa1P582815
E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (Ran-binding protein 2) (RanBP2)Ranbp2Q9ERU95
E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.-) (Protein ariadne-1 homolog) (ARI-1) (RING-type E3 ubiquitin transferase ARIH1) (UbcH7-binding protein) (UbcM4-interacting protein 77) (Ubiquitin-conjugating enzyme E2-binding protein 1)Arih1 Ari Ubch7bp Uip77Q9Z1K55
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)Rnf20 Bre1a Kiaa4116Q5DTM85
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1) (Protein open mind)Hectd1 Kiaa1131 OpmQ69ZR25
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)Hectd3Q3U4875
E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (Differentially expressed in branching tubulogenesis 91) (Debt-91) (RING-type E3 ubiquitin transferase KCMF1)Kcmf1 Debt91Q80UY25
Echinoderm microtubule-associated protein-like 4 (EMAP-4)Eml4Q3UMY55
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Lymphocyte antigen 41) (Ly-41) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]Enpp1 Npps Pc1 Pdnp1P068025
EGF-containing fibulin-like extracellular matrix protein 1 (Fibulin-3) (FIBL-3)Efemp1 Fbln3Q8BPB55
EGF-like repeat and discoidin I-like domain-containing protein 3 (EGF-like repeats and discoidin I-like domains 3, isoform CRA_a) (Putative uncharacterized protein)Edil3 mCG_142525Q8C4U85
EH domain-binding protein 1-like protein 1 (Tangerin)Ehbp1l1Q99MS75
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)EtfdhQ921G75
Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1)Gfm1 Efg Efg1 GfmQ8K0D55
Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)Edf1Q9JMG15
Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL)LipgQ9WVG55
Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Centrocyclin) (Centrosomal protein CCD41) (Endothelial cell protein C receptor) (CD antigen CD201)Procr EpcrQ646955
Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)Eci1 DciP421255
Envelope polyprotein (Putative envelope protein)envQ811M85
Ephrin type-A receptor 6Epha6G1K3815
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)Eps8l2 Eps8r2Q99K305
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)Eps15P425675
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)Eif1ax Eif1ayQ8BMJ35
Eukaryotic translation initiation factor 2 subunit 3, Y-linked (Eukaryotic translation initiation factor 2 subunit gamma, Y-linked) (eIF-2-gamma Y) (Spermatogonial proliferation factor) (Spy)Eif2s3yQ9Z0N25
Eukaryotic translation initiation factor 2B, subunit 3 (MCG14442)Eif2b3 mCG_14442B1AUN25
Eukaryotic translation initiation factor 3 subunit J-A (eIF3j-A) (Eukaryotic translation initiation factor 3 subunit 1-A) (eIF-3-alpha-A) (eIF3 p35)Eif3j1 Eif3s1-1Q3UGC75
Eukaryotic translation initiation factor 4 gamma 1Eif4g1E9PVC65
Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)Eif4g3Q80XI35
Exocyst complex component 1 (Exocyst complex component Sec3)Exoc1 Sec3 Sec3l1Q8R3S65
Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41)Exosc4 Rrp41Q921I95
Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog)Ext2P704285
FAS-associated factor 1Faf1P547315
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