EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)KRT14P025337
Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)KIF20A MKLP2 RAB6KIFLO952357
Kinetochore-associated protein NSL1 homologNSL1 C1orf48 DC31 DC8 MIS14Q96IY17
KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)KANK2 ANKRD25 KIAA1518 MXRA3 SIPQ63ZY37
KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1)KRR1 HRB2Q136017
Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1)KLF13 BTEB3 NSLP1Q9Y2Y97
Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2)KLF16 BTEB4 NSLP2Q9BXK17
L antigen family member 3 (Protein ESO-3) (Protein ITBA2)LAGE3 DXS9879E ESO3 ITBA2Q146577
La-related protein 1 (La ribonucleoprotein domain family member 1)LARP1 KIAA0731 LARPQ6PKG07
La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)LARP4B KIAA0217 LARP5Q926157
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)LGMN PRSC1Q995387
Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP)LEPROT LEPR OBRO152437
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)LZTS2 KIAA1813 LAPSER1Q9BRK47
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (Leucine-rich repeat neuronal protein 6D)LINGO4 LRRN6D UNQ9248/PRO34002Q6UY187
Leucine-rich repeat-containing protein 40LRRC40Q9H9A67
Leucine-rich repeat-containing protein 51 (Protein LRTOMT1)LRTOMT LRRC51Q96E667
Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34)LRRC59 PRO1855Q96AG47
Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)CD47 MER6Q087227
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)LAIR1 CD305Q6GTX87
Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7)LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7Q157227
Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta)LHBP012297
Lymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1)LY6E 9804 RIGE SCA2 TSA1Q165537
LYR motif-containing protein 1LYRM1O433257
Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]CTSA PPGBP106197
Macrophage-capping protein (Actin regulatory protein CAP-G)CAPG AFCP MCPP401217
Malcavernin (Cerebral cavernous malformations 2 protein)CCM2 C7orf22 PP10187Q9BSQ57
Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies)MCTS1 MCT1Q9ULC47
Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)SPG21 ACP33 BM-019 GL010Q9NZD87
MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog)MAU2 KIAA0892 SCC4Q9Y6X37
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)MED13L KIAA1025 PROSIT240 THRAP2 TRAP240LQ71F567
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)MED8Q96G257
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)ACADMP113107
Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)MLPH SLAC2AQ9BV367
Membrane protein FAM174BFAM174BQ3ZCQ37
Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1)MBTPS1 KIAA0091 S1P SKI1Q147037
Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE)MT1EP047327
Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein)MTSS1 KIAA0429 MIMO433127
Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]KISS1 PP5098Q157267
Methionine synthase reductase (MSR) (EC 1.16.1.8)MTRRQ9UBK87
Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.-)MSRB2 CBS-1 MSRB CGI-131Q9Y3D27
Methylenetetrahydrofolate reductase (Methylenetetrahydrofolate reductase short isoform) (Fragment)MTHFRQ8IU677
Microfibrillar-associated protein 1MFAP1P550817
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)DGCR8 C22orf12 DGCRK6 LP4941Q8WYQ57
Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45)MIIP IIP45Q5JXC27
MIP18 family protein FAM96AFAM96AQ9H5X17
MIT domain-containing protein 1MITD1Q8WV927
Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11)SLC25A11 SLC20A4Q029787
Mitochondrial carrier homolog 1 (Presenilin-associated protein)MTCH1 PSAP CGI-64 UNQ1871/PRO4314Q9NZJ77
Mitochondrial chaperone BCS1 (h-BCS1) (BCS1-like protein)BCS1L BCS1Q9Y2767
Mitochondrial enolase superfamily member 1 (EC 5.-.-.-) (Antisense RNA to thymidylate synthase) (rTS)ENOSF1 RTS TYMSASQ7L5Y17
Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) (MTP18)MTFP1 MTP18 HSPC242 My022Q9UDX57
Mitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed sequence 4)TIMM22 TEX4 TIM22Q9Y5847
Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) (UCPH)UCP2 SLC25A8P558517
Mitogen-activated protein kinase 1 (Mitogen-activated protein kinase 1, isoform CRA_a)MAPK1 hCG_32557Q1HBJ47
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)MAP4K5Q9Y4K47
Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1)MAPKBP1 JNKBP1 KIAA0596O603367
Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)MAD2L1 MAD2Q132577
MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA)MLXIP BHLHE36 KIAA0867 MIR MONDOAQ9HAP27
Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase accessory protein (Molybdenum cofactor biosynthesis protein C)]MOCS1 MIG11Q9NZB87
Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase)MOCOSQ96EN87
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)SPEN KIAA0929 MINT SHARPQ96T587
Myelin and lymphocyte protein (T-lymphocyte maturation-associated protein)MALP211457
Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)MLF2Q157737
Myeloid-associated differentiation marker (Protein SB135)MYADM UNQ553/PRO1110Q96S977
Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)MEF2A MEF2Q020787
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)MYH9P355797
N-lysine methyltransferase SETD8 (EC 2.1.1.-) (H4-K20-HMTase SETD8) (Histone-lysine N-methyltransferase SETD8) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)SETD8 KMT5A PRSET7 SET07 SET8Q9NQR17
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit)NDUFA1O152397
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (Complex I-KFYI) (CI-KFYI) (NADH-ubiquinone oxidoreductase KFYI subunit)NDUFC1O436777
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)NDUFS2O753067
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)NDUFS3O754897
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)NDUFS7O752517
NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)NDFIP1 N4WBP5 PSEC0192 PSEC0223Q9BT677
Negative elongation factor E (NELF-E) (RNA-binding protein RD)NELFE RD RDBPP186157
Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)MME EPNP084737
Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)NCS1 FLUP FREQP621667
Neuronal membrane glycoprotein M6-b (M6b)GPM6B M6BQ134917
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)IKBKG FIP3 NEMOQ9Y6K97
Nitrogen permease regulator 3-like protein (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Protein CGTHBA)NPRL3 C16orf35 CGTHBA MAREQ129807
NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 26) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9)NLRX1 NOD26 NOD5 NOD9Q86UT67
Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)NDEL1 EOPA MITAP1 NUDELQ9GZM87
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]NFKB2 LYT10Q006537
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4)NFATC3 NFAT4Q129687
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)NCOA1 BHLHE74 SRC1Q157887
Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)NOLC1 KIAA0035 NS5ATP13Q149787
Nucleolar GTP-binding protein 2 (Autoantigen NGP-1)GNL2 NGP1Q138237
Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)NME4 NM23DO007467
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)OPTN FIP2 GLC1E HIP7 HYPL NRPQ96CV97
OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)OTUD5Q96G747
Out at first protein homolog (HCV NS5A-transactivated protein 13 target protein 2)OAF NS5ATP13TP2Q86UD17
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)PDLIM7 ENIGMAQ9NR127
Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]PAMP190217
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)PIN1Q135267
Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP)PLIN2 ADFPQ995417
Peripheral myelin protein 22 (PMP-22) (Growth arrest-specific protein 3) (GAS-3)PMP22 GAS3Q014537
PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)PHF20 C20orf104 GLEA2 HCA58 NZF TZPQ9BVI07
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)PIP4K2B PIP5K2BP783567
Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta)PITPNBP487397
Phosphatidylinositol-glycan biosynthesis class F protein (PIG-F) (GPI11 homolog)PIGFQ073267
Phospholipase A-2-activating protein (PLA2P) (PLAP)PLAA PLAPQ9Y2637
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