EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2)LETMD1Q6P1Q09
Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)LRPPRC LRP130P427049
Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) (Cytokeratin-associated protein in cancer)LRRC26 CAPCQ2I0M49
Leucine-rich repeat-containing protein 29 (F-box and leucine-rich repeat protein 9) (F-box protein FBL9) (F-box/LRR-repeat protein 9)LRRC29 FBL9 FBXL9Q8WV359
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)LILRB1 ILT2 LIR1 MIR7Q8NHL69
Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase)LTA4H LTA4P099609
Lysophospholipase-like protein 1 (EC 3.1.2.-)LYPLAL1Q5VWZ29
Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14)LOXL2Q9Y4K09
Macrophage erythroblast attacher (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10)MAEA EMP HLC10 PIG5Q7L5Y99
Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2)NIPA2Q8N8Q99
Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18)GSTZ1 MAAIO437089
Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4)MLX BHLHD13 TCFL4Q9UH929
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Bardet-Biedl syndrome 6 protein)MKKS BBS6Q9NPJ19
MeninMEN1 SCG2O002559
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)TIMP2P160359
Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995Q9NZL99
Methylmalonic aciduria and homocystinuria type D protein, mitochondrialMMADHC C2orf25 CL25022 HSPC161 My011Q9H3L09
Methyltransferase-like protein 13 (EC 2.1.1.-)METTL13 KIAA0859 CGI-01Q8N6R09
Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)MFAP2 MAGP1P550019
Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]MAP1BP468219
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)MAPT MAPTL MTBT1 TAUP106369
Mitochondrial dynamic protein MID51 (Mitochondrial dynamic protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like)MIEF1 MID51 SMCR7LQ9NQG69
Mitochondrial fission factorMFF C2orf33 AD030 AD033 GL004Q9GZY89
Mitochondrial import inner membrane translocase subunit Tim10TIMM10 TIM10P620729
Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16)PAM16 MAGMAS TIM16 TIMM16 CGI-136Q9Y3D79
Mitochondrial pyruvate carrier 2 (Brain protein 44)MPC2 BRP44O955639
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)MAP3K2 MAPKKK2 MEKK2Q9Y2U59
Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B)MZT2B FAM128B MOZART2BQ6NZ679
Moesin (Membrane-organizing extension spike protein)MSNP260389
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)SMAD2 MADH2 MADR2Q157969
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)SMAD4 DPC4 MADH4Q134859
mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41)RAE1 MRNP41P784069
Myoferlin (Fer-1-like protein 3)MYOF FER1L3 KIAA1207Q9NZM19
Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)MYL6B MLC1SAP146499
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)MYL12B MRLC2 MYLC2BO149509
N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase)SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019Q96KG99
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (LYR motif-containing protein 6) (NADH-ubiquinone oxidoreductase B14 subunit)NDUFA6 LYRM6 NADHB14P565569
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)NDUFA9 NDUFS2LQ167959
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit)NDUFB6O951399
Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1)SLC11A1 LSH NRAMP NRAMP1P492799
NEDD8-conjugating enzyme Ubc12 (EC 6.3.2.-) (NEDD8 carrier protein) (NEDD8 protein ligase) (Ubiquitin-conjugating enzyme E2 M)UBE2M UBC12P610819
Neuroblastoma breakpoint family member 3 (Protein AE2) (Protein SHIIIa4)NBPF3 L7Q9H0949
Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)NET1 ARHGEF8Q7Z6289
Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)NBN NBS NBS1 P95O609349
Nitric oxide synthase-interacting protein (eNOS-interacting protein)NOSIP CGI-25Q9Y3149
Nuclear migration protein nudC (Nuclear distribution protein C homolog)NUDCQ9Y2669
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)NCOR2 CTG26Q9Y6189
Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)NR2F6 EAR2 ERBAL2P105889
Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)NXF1 TAPQ9UBU99
Nucleobindin-2 (DNA-binding protein NEFA) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]NUCB2 NEFAP803039
Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein)NOC3L AD24 C10orf117 FAD24Q8WTT29
Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3)NOP16 CGI-117 HSPC111Q9Y3C19
Nucleoplasmin-3NPM3O756079
Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)NME2 NM23BP223929
Olfactory receptor 4F3/4F16/4F29 (Olfactory receptor OR1-1)OR4F3; OR4F16; OR4F29Q6IEY19
Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2)ODF2Q5BJF69
Oxysterol-binding protein 1OSBP OSBP1P220599
p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)PAK1IP1 PIP1 WDR84Q9NWT19
Palladin (SIH002) (Sarcoma antigen NY-SAR-77)PALLD KIAA0992 CGI-151Q8WX939
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)PSIP1 DFS70 LEDGF PSIP2O754759
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)PPIE CYP33Q9UNP99
Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)PEX19 HK33 PXF OK/SW-cl.22P408559
Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)PDCL3 VIAF1Q9H2J49
Phosphatase and actin regulator 2PHACTR2 C6orf56 KIAA0680O751679
Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2)PEMT PEMPT PNMTQ9UBM19
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC 2.4.1.198) (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P)PIGP DCRC DSCR5 DSCRC NPD010P570549
Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)PAFAH1B3 PAFAHGQ151029
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)PCBP1Q153659
Poly(rC)-binding protein 4 (Alpha-CP4)PCBP4P577239
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)PABPC1 PAB1 PABP1 PABPC2P119409
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)PHC2 EDR2 PH2Q8IXK09
Polyubiquitin-B [Cleaved into: Ubiquitin]UBBP0CG479
PRAME family member 7PRAMEF7Q5VXH59
pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein WDC146)WDR33 WDC146Q9C0J89
Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)FIP1L1 FIP1 RHEQ6UN159
Pre-mRNA-splicing factor 38APRPF38AQ8NAV19
Prickle-like protein 4 (Overexpressed breast tumor protein)PRICKLE4 C6orf49 OEBTQ2TBC49
Proactivator polypeptide [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]PSAP GLBA SAP1P076029
Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47)DDX47Q9H0S49
Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56)DDX56 DDX21 NOH61Q9NY939
Probable palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 16) (DHHC-16)ZDHHC16 UNQ2570/PRO6258Q969W19
Probable phosphoglycerate mutase 4 (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4)PGAM4 PGAM3Q8N0Y79
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)USP9X DFFRX FAM USP9Q930089
Programmed cell death protein 6 (Apoptosis-linked gene 2 protein) (Probable calcium-binding protein ALG-2)PDCD6 ALG2O753409
ProhibitinPHBP352329
Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23)PTGES3 P23 TEBPQ151859
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)PSME1 IFI5111Q063239
Proteasome subunit alpha type-4 (EC 3.4.25.1) (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)PSMA4 HC9 PSC9P257899
Proteasome subunit alpha type-6 (EC 3.4.25.1) (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)PSMA6 PROS27P609009
Proteasome subunit alpha type-7 (EC 3.4.25.1) (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)PSMA7 HSPCO148189
Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)PSMB10 LMP10 MECL1P403069
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)PSMB5 LMPX MB1 XP280749
Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)PSMB8 LMP7 PSMB5i RING10 Y2P280629
Protein amnionlessAMN UNQ513/PRO1028Q9BXJ79
Protein BEX3 (Brain-expressed X-linked protein 3) (Nerve growth factor receptor-associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) (p75NTR-associated cell death executor)NGFRAP1 BEX3 DXS6984E NADEQ009949
Protein C10C12orf57 C10Q996229
Protein CMSS1 (Cms1 ribosomal small subunit homolog)CMSS1 C3orf26Q9BQ759
Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)AHCTF1 ELYS TMBS62 MSTP108Q8WYP59
Protein FADD (FAS-associated death domain protein) (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)FADD MORT1 GIG3Q131589
Protein FAM110AFAM110A C20orf55 F10Q9BQ899
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