EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Pericentriolar material 1 protein (PCM-1) (mPCM-1)Pcm1Q9R0L66
Peroxiredoxin 6 (Peroxiredoxin-6) (Putative uncharacterized protein)Prdx6Q6GT246
Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)Crot CotQ9DC506
Phosducin-like protein 3 (Viral IAP-associated factor 1) (VIAF-1)Pdcl3 Viaf1Q8BVF26
Phospholipid phosphatase 1 (EC 3.1.3.4) (35 kDa PAP) (mPAP) (Hydrogen peroxide-inducible protein 53) (Hic53) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)Plpp1 Hpic53 Lpp1 Ppap2aQ614696
Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)Plpp2 Lpp2 Ppap2cQ9DAX26
Plakophilin 2 (Putative uncharacterized protein)Pkp2 mCG_126835Q9CQ736
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)Pdgfrb Pdgfr Pdgfr1P056226
Pleckstrin homology domain-containing, family A member 5Plekha5E9Q6H86
Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neutrophic factor) (HBNF) (Osteoblast-specific factor 1) (OSF-1)PtnP630896
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30)Parp1 Adprt1 mCG_19846Q921K26
Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9)Nol9Q3TZX86
Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]Galnt2Q6PB936
Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog)Cwc22 NcmQ8C5N36
Prefoldin 1 (Prefoldin subunit 1) (Putative uncharacterized protein)Pfdn1 mCG_121970Q9CQF76
Prefoldin subunit 5 (C-Myc-binding protein Mm-1) (EIG-1) (Myc modulator 1)Pfdn5 Eig1 Mm1 Pfd5Q9WU286
Pro-cathepsin H (Cathepsin B3) (Cathepsin BA) [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]CtshP499356
Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46)Ddx46 Kiaa0801Q569Z56
Prolargin (Proline-arginine-rich end leucine-rich repeat protein)PrelpQ9JK536
Proline synthase co-transcribed bacterial homolog proteinProscQ9Z2Y86
Prostaglandin E synthase 3Ptges3D3Z7C66
Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (Glucocorticoid-regulated inflammatory cyclooxygenase) (Gripghs) (Macrophage activation-associated marker protein P71/73) (PES-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) (TIS10 protein)Ptgs2 Cox-2 Cox2 Pghs-b Tis10Q057696
Protease, serine 3 (Trypsinogen 11)Prss3 Tcrb-V20 trypsinogenQ792Z06
Protein FAM49AFam49a D12Ertd553eQ8BHZ06
Protein jagged-1 (Jagged1) (CD antigen CD339)Jag1Q9QXX06
Protein kinase, cAMP dependent regulatory, type II alpha (Protein kinase, cAMP dependent regulatory, type II alpha, isoform CRA_b) (Putative uncharacterized protein) (cAMP-dependent protein kinase type II-alpha regulatory chain) (cAMP-dependent protein kinase type II-alpha regulatory subunit)Prkar2a mCG_16488Q8K1M36
Protein LYRIC (3D3/LYRIC) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)Mtdh LyricQ80WJ76
Protein piccolo (Aczonin) (Brain-derived HLMN protein) (Multidomain presynaptic cytomatrix protein)Pclo AczQ9QYX76
Protein Red (Cytokine IK) (IK factor) (Protein RER)Ik Red RerQ9Z1M86
Protein shisa-4 (Transmembrane protein 58)Shisa4 Tmem58Q8CA716
Protein SON (Negative regulatory element-binding protein) (NRE-binding protein)Son NrebpQ9QX476
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)Sec61a1 Sec61aP616206
Protein unc-119 homolog A (Retinal protein 4) (mRG4)Unc119 Unc119hQ9Z2R66
Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) (Ras excision protein)Lox RrgP283016
PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)Gulp1 Ced6Q8K2A16
Putative uncharacterized protein (RAS-related C3 botulinum substrate 1, isoform CRA_a) (Ras-related C3 botulinum toxin substrate 1)Rac1 mCG_23557Q3TLP86
Putative uncharacterized protein (Sorting nexin 3) (Sorting nexin 3, isoform CRA_b) (Sorting nexin-3)Snx3 mCG_121767Q78ZM06
Putative uncharacterized protein (Syntaxin 7) (Syntaxin-7)Stx7 Stx-7 mCG_6753Q8BH406
Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)Pycr2Q922Q46
Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)CryzP471996
Ran-binding protein 9 (RanBP9) (B-cell antigen receptor Ig beta-associated protein 1) (IBAP-1) (Ran-binding protein M) (RanBPM)Ranbp9 RanbpmP695666
RAP1, GTP-GDP dissociation stimulator 1Rap1gds1E9Q9126
Ras-related protein Rab-27ARab27aQ9ERI26
Ras-related protein Rab-30Rab30 Rsb30Q923S96
Receptor-type tyrosine-protein phosphatase etaPtprjE9Q4S76
Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)Ptprf LarA2A8L56
Reticulocalbin-1Rcn1 Rca1 RcnQ051866
Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)Arhgap30Q640N36
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)Arhgef12 Kiaa0382 LargQ8R4H26
Rho guanine nucleotide exchange factor 39Arhgef39Q66JY66
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)Rock2P703366
Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2)Rpp30 Rnasep2O887966
Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog)Las1lA2BE286
Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)Wdr12 MNCb-5414Q9JJA46
RIKEN cDNA D630045J12 geneD630045J12RikD3YTS36
RING finger and SPRY domain-containing protein 1Rspry1 Kiaa1972Q8BVR66
RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1)RtcA Rpc1 Rtcd1Q9D7H36
RNA-binding protein with serine-rich domain 1Rnps1Q99M286
RRP12-like proteinRrp12 Kiaa0690Q6P5B06
S-formylglutathione hydrolase (EC 3.1.2.12)EsdH3BKH66
Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29)Sacs Kiaa0730Q9JLC86
Secernin-1Scrn1 Kiaa0193Q9CZC86
Serine incorporator 1 (Axotomy-induced glyco/Golgi protein 2) (Membrane protein TMS-2) (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2)Serinc1 Aigp2 Tde1l Tde2 Tms2Q9QZI86
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf)Araf A-raf Araf1P046276
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PPT)Ppp5cQ606766
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44)Ankrd44B2RXR66
SH3 domain-binding glutamic acid-rich-like protein 3Sh3bgrl3Q91VW36
SH3 domain-binding protein 1 (3BP-1)Sh3bp1 3bp1P551946
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)AcadsQ074176
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)AcadsbQ9DBL16
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)Sppl2a Imp3 Psl2 MNCb-3763Q9JJF96
Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)SnrpfP623076
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)Snrpn SmnP631636
Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA)Sorl1O883076
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (mSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)Sgpl1Q8R0X76
Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)Sf3b5 Sf3b10Q923D46
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1)Spred1Q924S86
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170)NsdhlQ9R1J06
Striatin-4 (Zinedin)Strn4 ZinP584046
Synaptogyrin-1Syngr1O551006
Synaptotagmin-4 (Synaptotagmin IV) (SytIV)Syt4 Syt3P407496
Syntaxin-binding protein 2 (Fragment)Stxbp2F8WGM56
Tensin-2 (EC 3.1.3.-) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)Tns2 Tenc1Q8CGB66
Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog)Aspscr1 TugQ8VBT96
Thrombospondin-3Thbs3 Tsp3Q058956
Thyroglobulin (Tg)Tg TgnO087106
Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]PlatP112146
TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1)Traf4 Cart1Q613826
Transducin beta-like protein 3Tbl3Q8C4J76
Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)Tra2aQ6PFR56
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)Trpv4 Trp12 Vrl2 VroacQ9EPK86
Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha)Eif2b1Q99LC86
Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1 homolog) (Tumor-associated antigen L6)Tm4sf1 M3s1Q643026
Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2 homolog)Tmc8 Ever2Q7TN586
Transmembrane emp24 domain-containing protein 3 (p24 family protein gamma-4) (p24gamma4)Tmed3Q78IS16
Transmembrane protein 43 (Protein LUMA)Tmem43Q9DBS16
Transthyretin (Prealbumin)TtrP073096
Triple functional domain protein (EC 2.7.11.1)TrioQ0KL026
Tumor protein D52 (mD52)Tpd52Q623936
Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2)Tacstd2 Trop2Q8BGV36
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