EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (D1Pas1-related sequence 1) (DEAD box protein 3, Y-chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2)Ddx3y D1Pas1-rs1 Dead2Q620959
B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (p28)Bcap31 Bap31Q613359
Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)Birc6 Kiaa1289O887389
Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase)Glb1 Bgl Glb-1P237809
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)Baiap2l1 IrtksQ9DBJ39
C-terminal-binding protein 2 (CtBP2)Ctbp2P565469
Cadherin-1 (ARC-1) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]Cdh1P098039
Carboxypeptidase Q (EC 3.4.17.-) (Hematopoietic lineage switch 2) (Plasma glutamate carboxypeptidase)Cpq Hls2 PgcpQ9WVJ39
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1)Cnot1 Kiaa1007Q6ZQ089
CD44 antigen (Putative uncharacterized protein)Cd44Q3U8S19
Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)Tmem30a Cdc50a D9Wsu20eQ8VEK09
Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)Cdc23 Anapc8Q8BGZ49
Centromere/kinetochore protein zw10 homologZw10O546929
Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)Cep162 Kiaa1009 Qn1Q6ZQ069
Charged multivesicular body protein 1b-1 (Chromatin-modifying protein 1b-1) (CHMP1b-1)Chmp1b1 Chmp1bQ99LU09
Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (M32) (Modifier 2 protein)Cbx3P231989
Coiled-coil domain-containing protein 22Ccdc22 DXImx40eQ9JIG79
COMM domain-containing protein 3 (Bmi-1 upstream gene protein) (Bup protein)Commd3 BupQ638299
Complement C1q subcomponent subunit BC1qbP141069
Complement C1q subcomponent subunit CC1qc C1qgQ021059
Complement C5 (Hemolytic complement) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]C5 HcP066849
Coxsackievirus and adenovirus receptor homolog (CAR) (mCAR)Cxadr CarP977929
Cytochrome b5Cyb5a Cyb5P563959
Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)Cox6b1 Cox6bP563919
Cytochrome c, somaticCycsP628979
Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)Cyc1Q9D0M39
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)Nck2 Grb4O550339
Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63)Ckap4Q8BMK49
Cytoskeleton-associated protein 5Ckap5A2AGT59
Dedicator of cytokinesis protein 7 (Protein moonlight)Dock7 Gm430 Kiaa1771 MnltQ8R1A49
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)Ddr2 Ntrkr3 Tkt Tyro10Q623719
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit)Polr2a Rpii215 Rpo2-1P087759
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (RPB17) (RPB8 homolog)Polr2hQ923G29
DnaJ heat shock protein family (Hsp40) member C13 (MCG115602)Dnajc13 mCG_115602G3X9229
DnaJ homolog subfamily B member 1 (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40)Dnajb1 Hsp40 Hspf1Q9QYJ39
Echinoderm microtubule-associated protein-like 2 (EMAP-2)Eml2Q7TNG59
Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2) (EC 3.6.1.-) (CD39 antigen-like 1) (Ecto-ATP diphosphohydrolase 2) (Ecto-ATPDase 2) (Ecto-ATPase 2)Entpd2 Cd39l1O550269
Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)Ece1Q4PZA29
Exportin-7 (Exp7) (Ran-binding protein 16)Xpo7 Kiaa0745 Ranbp16Q9EPK79
Extracellular sulfatase Sulf-2 (mSulf-2) (EC 3.1.6.-)Sulf2Q8CFG09
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)Fbxw11 Btrcp2 Fbw1b Fbxw1bQ5SRY79
FERM domain-containing protein 8Frmd8Q3UFK89
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]FgaE9PV249
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)Ptk2 Fadk Fak Fak1 Kiaa4203P341529
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)Grk6 Gprk6O702939
G-protein coupled receptor family C group 5 member B (Retinoic acid-induced gene 2 protein) (RAIG-2)Gprc5b Raig2Q923Z09
Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)Eno2 Eno-2P171839
Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]Ggt1 Ggt GgtpQ609289
General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein)Uso1 VdpQ9Z1Z09
Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin)Gnpda1 GnpiO889589
Glutaredoxin-1 (Thioltransferase-1) (TTase-1)Glrx Glrx1 Grx Grx1Q9QUH09
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]Gpc4P516559
GTP-binding protein SAR1a (Putative uncharacterized protein) (SAR1 gene homolog A (S. cerevisiae)) (SAR1 gene homolog A (S. cerevisiae), isoform CRA_b)Sar1a Sara1 mCG_15771Q99JZ49
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)Gng2P632139
H-2 class I histocompatibility antigen, D-D alpha chain (H-2D(D))H2-D1P019009
H-2 class I histocompatibility antigen, K-K alpha chain (H-2K(K))H2-K1 H2-KP042239
Heat shock 70 kDa protein 13 (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein)Hspa13 StchQ8BM729
Heat shock 70 kDa protein 14 (NST-1) (hsr.1)Hspa14 Hsp70-4Q99M319
Heat shock protein beta-1 (HspB1) (Growth-related 25 kDa protein) (Heat shock 25 kDa protein) (HSP 25) (Heat shock 27 kDa protein) (HSP 27) (p25)Hspb1 Hsp25 Hsp27P146029
Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)Hat1Q8BY719
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (YY1 transcription factor-binding protein)Hdac2 Yy1bpP702889
Histone H2A type 1-KHist1h2akQ8CGP79
Histone H2B type 1-A (Histone H2B, testis) (Testis-specific histone H2B)Hist1h2ba Th2bP706969
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)HmgclP380609
Ig gamma-1 chain C region secreted formIghg1 Igh-4P018689
Immunity-related GTPase family M protein 1 (EC 3.6.5.-) (Interferon-inducible GTPase 3) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47) (LRG-47)Irgm1 Ifi1 Iigp3 IrgmQ607669
Immunoglobulin J chainJchain IgjP015929
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)Kpna4 Qip1O353439
Insulin-degrading enzyme (Fragment)IdeF6RPJ99
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (mIMP-3) (IGF-II mRNA-binding protein 3) (VICKZ family member 3)Igf2bp3 Vickz3Q9CPN89
Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b)ItgamP055559
Keratin, type I cytoskeletal 13 (47 kDa cytokeratin) (Cytokeratin-13) (CK-13) (Keratin-13) (K13)Krt13 Krt1-13P087309
Kinesin-like protein KIF2A (Kinesin-2)Kif2a Kif2 Kns2P287409
Lamina-associated polypeptide 2, isoforms alpha/zeta (Thymopoietin isoforms alpha/zeta) (TP alpha/zeta)Tmpo Lap2Q610339
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)Lgmn Prsc1O890179
Leukocyte elastase inhibitor A (Serine protease inhibitor EIA) (Serpin B1a)Serpinb1a Serpinb1Q9D1549
Lipoma-preferred partner homologLppQ8BFW79
Lipopolysaccharide-binding protein (LBP)LbpQ618059
Major vault proteinMvpE9Q3X09
Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog)Spg21Q9CQC89
MCG21756, isoform CRA_b (Nucleoporin 205) (Nup205 protein)Nup205 mCG_21756B9EJ549
Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (mACDP4) (Cyclin-M4)Cnnm4 Acdp4 Kiaa1592Q69ZF79
Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3)Timp3 Sun Timp-3P398769
Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta)Mat2bQ99LB69
Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1)Metap1Q8BP489
Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein)Mri1Q9CQT19
MICOS complex subunit Mic60 (Mitochondrial inner membrane protein) (Mitofilin)Immt Mic60Q8CAQ89
MMS19 nucleotide excision repair protein homolog (MET18 homolog) (MMS19-like protein)Mms19 Mms19lQ9D0719
Myelin proteolipid protein (PLP) (Lipophilin)Plp1 PlpP602029
N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25)Naa25 Mdm20Q8BWZ39
NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)Me2Q99KE19
NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) (mSIR2L2)Sirt2 Sir2l2Q8VDQ89
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)Ndufs3Q9DCT29
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP1) (WW domain-containing protein 1)Wwp1Q8BZZ39
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1)Nae1 Appbp1Q8VBW69
NeogeninNeo1E9QK049
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B)Unc5b Unc5h2Q8K1S39
Neural Wiskott-Aldrich syndrome protein (N-WASP)WaslQ91YD99
Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog)Ncs1 FreqQ8BNY69
Neutrophil collagenase (EC 3.4.24.34) (Collagenase 2) (Matrix metalloproteinase-8) (MMP-8)Mmp8O701389
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