EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20)EIF1BO607398
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)EIF2S1 EIF2AP051988
Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005Q9Y2628
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)FBXW4 FBW4 SHFM3P577758
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)FBXW7 FBW7 FBX30 SEL10Q969H08
Factor VIII intron 22 protein (CpG island protein)F8A1 F8A; F8A2 F8A; F8A3 F8AP236108
FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region]FLAD1 PP591Q8NFF58
Fanconi anemia-associated protein of 20 kDaFAAP20 C1orf86 FP7162Q6NZ368
Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase)FADS1 FADSD5O604278
Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase 10) (Aldehyde dehydrogenase family 3 member A2) (Microsomal aldehyde dehydrogenase)ALDH3A2 ALDH10 FALDHP516488
Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)FERMT2 KIND2 MIG2 PLEKHC1Q96AC18
FGFR1 oncogene partner 2FGFR1OP2 HSPC123Q9NVK58
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFRP113628
Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)FZR1 CDH1 FYR FZR KIAA1242Q9UM118
Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)BLVRB FLRP300438
Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)FLOT2 ESA1 M17S1Q142548
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)FNBP1 FBP17 KIAA0554Q96RU38
G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18)GPSM3 AGS4 C6orf9 G18Q9Y4H48
G1/S-specific cyclin-D3CCND3P302818
G2/mitotic-specific cyclin-B2CCNB2O950678
GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2)GABPB2Q8TAK58
Galactokinase (EC 2.7.1.6) (Galactose kinase)GALK1 GALKP515708
Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)LGALS3 MAC2P179318
Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor)GIPRP485468
GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]H6PD GDHO954798
General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)GTF2F1 RAP74P352698
General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein)USO1 VDPO607638
Germinal-center associated nuclear protein (GANP) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase)MCM3AP GANP KIAA0572 MAP80O603188
Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2)SERPINE2 PI7 PN1P070938
Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin)GNPDA1 GNPI HLN KIAA0060P469268
Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH)PRKCSH G19P1P143148
Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)GLUD1 GLUDP003678
Glutamine-rich protein 1QRICH1Q2TAL88
Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)GLRX3 PICOT TXNL2 HUSSY-22O760038
Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase)GPX1P072038
Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)GSR GLUR GRD1P003908
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8)GPD1L KIAA0089Q8N3358
Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (hGAA1)GPAA1 GAA1O432928
Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118)GADD45B MYD118O752938
GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1)ERAL1 HERAO756168
Guanine nucleotide-binding protein G(k) subunit alpha (G(i) alpha-3)GNAI3P087548
Guanine nucleotide-binding protein-like 3-like proteinGNL3LQ9NVN88
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)HDDC3 MESH1Q8N4P38
HD domain-containing protein 2 (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2)HDDC2 C6orf74 NS5ATP2 CGI-130Q7Z4H38
Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)TRAP1 HSP75Q129318
Heat shock protein beta-11 (Hspb11) (Placental protein 25) (PP25)HSPB11 C1orf41 HSPC034Q9Y5478
Hematological and neurological expressed 1-like protein (HN1-like protein)HN1L C16orf34 L11Q9H9108
Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)HNF1B TCF2P356808
Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)HDGFRP2 HDGF2 UNQ785/PRO1604Q7Z4V58
Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0)HNRNPA0 HNRPA0Q131518
Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I)HK1P193678
High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)HMGB3 HMG2A HMG4O153478
Histone deacetylase 1 (HD1) (EC 3.5.1.98)HDAC1 RPD3L1Q135478
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)HDAC7 HDAC7AQ8WUI48
Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]H1F0 H1FVP073058
Histone H2B type 1-D (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b)HIST1H2BD H2BFB HIRIP2P588768
HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)HLA-F HLA-5.4 HLAFP305118
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)HLA-DRA HLA-DRA1P019038
Homeobox protein SIX4 (Sine oculis homeobox homolog 4)SIX4Q9UIU68
Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein)PSMC3IP HOP2 TBPIPQ9P2W18
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)HMGCLP359148
Immortalization up-regulated protein (Hepatocyte growth factor activator inhibitor type 2-related small protein) (H2RSP) (HAI-2-related small protein)IMUP C19orf33Q9GZP88
Immunity-related GTPase family Q proteinIRGQ IRGQ1 FKSG27Q8WZA98
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)KPNA2 RCH1 SRP1P522928
Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)IPO5 KPNB3 RANBP5O004108
Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)IMPDH1 IMPD1P208398
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2ITPRIPL2Q3MIP18
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)IGF2BP2 IMP2 VICKZ2Q9Y6M18
Integrator complex subunit 10 (Int10)INTS10 C8orf35Q9NVR28
Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]ITGAEP385708
Interferon regulatory factor 3 (IRF-3)IRF3Q146538
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)EIF2AK2 PKR PRKRP195258
Interferon-related developmental regulator 2 (Protein SKMC15)IFRD2Q128948
Interleukin-1 beta (IL-1 beta) (Catabolin)IL1B IL1F2P015848
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)IL18 IGIF IL1F4Q141168
Intersex-like (Drosophila) (cDNA FLJ54860, highly similar to Homo sapiens intersex-lik (IXL), mRNA)IXL hCG_43365B4DUA78
Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)IARS2Q9NSE48
KATNB1-like protein 1 (Katanin p80 subunit B-like 1)KATNBL1 C15orf29Q9H0798
Kelch-like protein 22KLHL22Q53GT18
Kelch-like protein 5KLHL5Q96PQ78
Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein)FN3KRPQ9HA648
Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4)KIF22 KID KNSL4Q148078
KinocilinKNCNA6PVL38
Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)KLF10 TIEG TIEG1Q131188
Late cornified envelope protein 1A (Late envelope protein 1)LCE1A LEP1Q5T7P28
Late cornified envelope protein 1C (Late envelope protein 3)LCE1C LEP3Q5T7518
Late cornified envelope protein 1D (Late envelope protein 4)LCE1D LEP4Q5T7528
Leucine-rich repeat-containing G-protein coupled receptor 6LGR6 UNQ6427/PRO21331 VTS20631Q9HBX88
Leucine-rich repeat-containing protein 42LRRC42Q9Y5468
LIM and calponin homology domains-containing protein 1LIMCH1 KIAA1102Q9UPQ08
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)DBT BCATE2P111828
Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)LRBA BGL CDC4L LBAP508518
Lon protease homolog 2, peroxisomal (EC 3.4.21.-) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease)LONP2 LONPQ86WA88
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4)ACSL4 ACS4 FACL4 LACS4O604888
Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34)LSP1 WP34P332418
Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (EC 2.3.1.n4) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7)MBOAT7 BB1 LENG4 OACT7Q96N668
Lysosomal protein NCU-G1C1orf85 PSEC0030 UNQ2553/PRO6182Q8WWB78
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (CD antigen CD107b)LAMP2P134738
Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) [Cleaved into: Processed macrophage colony-stimulating factor 1]CSF1P096038
Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)MSL3 MSL3L1Q8N5Y28
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