EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Immunoglobulin heavy constant delta (Ig delta chain C region) (Ig delta chain C region NIG-65) (Ig delta chain C region WAH)IGHDP0188039
Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2)KIF5C KIAA0531 NKHC2O6028239
Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein)MGP MGLAP GIG36P0849339
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)NF2 SCHP3524039
Mitochondrial import inner membrane translocase subunit TIM44TIMM44 MIMT44 TIM44O4361539
Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)TOMM40 C19orf1 PEREC1 TOM40O9600839
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (LYR motif-containing protein 3) (NADH-ubiquinone oxidoreductase B22 subunit)NDUFB9 LYRM3 UQOR22Q9Y6M939
Pancreatic alpha-amylase (PA) (EC (1,4-alpha-D-glucan glucanohydrolase)AMY2AP0474639
Protein FAM65AFAM65A KIAA1930Q6ZS1739
Ras-related protein Rab-15RAB15P5919039
Ras-related protein Rab-4BRAB4B PP1596P6101839
Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)RPRD1B C20orf77 CREPTQ9NQG539
Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)CANT1 SHAPYQ8WVQ139
Spastin (EC (Spastic paraplegia 4 protein)SPAST ADPSP FSP2 KIAA1083 SPG4Q9UBP039
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC (Iron-sulfur subunit of complex II) (Ip)SDHB SDH SDH1P2191239
SymplekinSYMPK SPKQ9279739
Trafficking protein particle complex subunit 5TRAPPC5Q8IUR039
Tubulin alpha-3C/D chain (Alpha-tubulin 2) (Alpha-tubulin 3C/D) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C/D chain]TUBA3C TUBA2; TUBA3DQ1374839
U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')SNRPB2P0857939
Ubiquitin-protein ligase E3C (EC (HECT-type ubiquitin transferase E3C) (HectH2)UBE3C KIAA0010 KIAA10Q1538639
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT)OGTO1529439
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC 2.7.7.-)UAP1L1Q3KQV939
Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC UPQ1683139
Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)KCNAB2 KCNA2B KCNK2Q1330339
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC (Prostaglandin dehydrogenase 1) (Short chain dehydrogenase/reductase family 36C member 1)HPGD PGDH1 SDR36C1P1542838
3-ketoacyl-CoA thiolase, peroxisomal (EC (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase)ACAA1 ACAA PTHIOP0911038
Adenylate kinase 4, mitochondrial (AK 4) (EC (EC (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)AK4 AK3 AK3L1P2714438
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)AEBP1 ACLPQ8IUX738
Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1 aldehyde reductase 2) (AFB1-AR 2)AKR7A3 AFAR2O9515438
Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)AKR1B10 AKR1B11O6021838
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)RAI14 KIAA1334 NORPEGQ9P0K738
Coagulation factor XII (EC (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]F12P0074838
Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)C1RL C1RL1 C1RLP CLSPAQ9NZP838
Corneodesmosin (S protein)CDSNQ1551738
Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin)SERPINA6 CBGP0818538
CTP synthase 2 (EC (CTP synthetase 2) (UTP--ammonia ligase 2)CTPS2Q9NRF838
Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C)UQCRQO1494938
Disheveled-associated activator of morphogenesis 1DAAM1 KIAA0666Q9Y4D138
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)ADAM15 MDC15Q1344438
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)ADAM17 CSVP TACEP7853638
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKEQ0834538
Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)FLVCR1 FLVCRQ9Y5Y038
Geranylgeranyl transferase type-2 subunit beta (EC (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)RABGGTB GGTBP5361138
Immunoglobulin kappa variable 1D-12 (Ig kappa chain V-I region Wes)IGKV1D-12P0161138
Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)IGFBP4 IBP4P2269238
Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)KRT27 KRT25CQ7Z3Y838
Kinesin-like protein KIF2A (Kinesin-2) (hK2)KIF2A KIF2 KNS2O0013938
Kinetochore protein Spc24 (hSpc24)SPC24 SPBC24Q8NBT238
KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1)KRR1 HRB2Q1360138
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)BIN1 AMPHLO0049938
NestinNES Nbla00170P4868138
Non-syndromic hearing impairment protein 5 (Inversely correlated with estrogen receptor expression 1) (ICERE-1)DFNA5 ICERE1O6044338
Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3)PPIL3Q9H2H838
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)PELP1 HMX3 MNARQ8IZL838
Protein AHNAK2AHNAK2 C14orf78 KIAA2019Q8IVF238
Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC (Guanine insertion enzyme) (tRNA-guanine transglycosylase)QTRT1 TGT TGUTQ9BXR038
Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)LAMTOR5 HBXIP XIPO4350438
Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m)RASA2 GAP1M RASGAPQ1528338
RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10)NAT10 ALP KIAA1709Q9H0A038
Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24)SEPT1 DIFF6 PNUTL3Q8WYJ638
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC (Protein phosphatase X) (PP-X)PPP4C PPP4 PPXP6051038
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)ANKRD28 KIAA0379O1508438
Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)]SAA1P0DJI838
Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)SLC6A8P4802938
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)SLC12A4 KCC1Q9UP9538
Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)SPTA1 SPTAP0254938
Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)SF3A2 SAP62Q1542838
Sulfhydryl oxidase 2 (EC (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1)QSOX2 QSCN6L1 SOXNQ6ZRP738
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)SMARCE1 BAF57Q969G338
Thiopurine S-methyltransferase (EC (Thiopurine methyltransferase)TPMTP5158038
Thiosulfate sulfurtransferase (EC (Rhodanese)TSTQ1676238
TP53-regulating kinase (EC (Atypical serine/threonine protein kinase TP53RK) (EKC/KEOPS complex subunit TP53RK) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase)TP53RK C20orf64 PRPKQ96S4438
U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K)USP39 CGI-21 HSPC332 PRO2855Q53GS938
Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog)VPS51 ANG2 C11orf2 C11orf3 FFR PP5382Q9UID338
Vacuolar protein sorting-associated protein 53 homologVPS53 PP13624Q5VIR638
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)YBX3 CSDA DBPAP1698938
Acetyl-coenzyme A synthetase, cytoplasmic (EC (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme)ACSS2 ACAS2Q9NR1937
Alpha-amylase 2B (EC (1,4-alpha-D-glucan glucanohydrolase 2B) (Carcinoid alpha-amylase)AMY2BP1996137
ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2)ABCF2 HUSSY-18Q9UG6337
Beta-glucuronidase (EC (Beta-G1)GUSBP0823637
Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3)CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3Q9HCU437
Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)CHI3L1P3622237
Cilia- and flagella-associated protein 20 (Basal body up-regulated protein 22) (Transcription factor IIB)CFAP20 BUG22 C16orf80Q9Y6A437
Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)CCDC6 D10S170 TST1Q1620437
Cyclin-Y-like protein 1CCNYL1Q8N7R737
Cysteine dioxygenase type 1 (EC (Cysteine dioxygenase type I) (CDO) (CDO-I)CDO1Q1687837
DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1)DDRGK1 C20orf116 UFBP1Q96HY637
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)DERL1 DER1 UNQ243/PRO276Q9BUN837
DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)DNAJB6 HSJ2 MRJ MSJ1O7519037
Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1)DYSF FER1L1O7592337
Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)ERLIN1 C10orf69 KE04 KEO4 SPFH1O7547737
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)B3GAT3O9476637
Glial fibrillary acidic protein (GFAP)GFAPP1413637
Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14)GNA14O9583737
Histone H2A.J (H2a/j)H2AFJQ9BTM137
Histone H2B type 1-M (Histone H2B.e) (H2B/e)HIST1H2BM H2BFEQ9987937
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E)HLA-E HLA-6.2 HLAEP1374737
Immunoglobulin heavy variable 3-7 (Ig heavy chain V-III region GAL) (Ig heavy chain V-III region GAR) (Ig heavy chain V-III region JON)IGHV3-7P0178037
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