EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein)POTEF A26C1BA5A3E068
Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2)PROM2 PROML2 UNQ2521/PRO6014Q8N27168
Sorting nexin-1SNX1Q1359668
Thimet oligopeptidase (EC (Endopeptidase 24.15) (MP78)THOP1P5288868
TRAF2 and NCK-interacting protein kinase (EC KIAA0551Q9UKE568
WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)WASHC5 KIAA0196Q1276868
ATP-dependent RNA helicase DDX19A (EC (DDX19-like protein) (DEAD box protein 19A)DDX19A DDX19LQ9NUU767
Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC (Dephosphocoenzyme A kinase) (DPCOAK)]COASY PSEC0106Q1305767
Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)CDH13 CDHHP5529067
Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)CNTN1Q1286067
Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2)NUBP2Q9Y5Y267
Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)HRGP0419667
Histone H2A type 1-H (Histone H2A/s)HIST1H2AH HIST1H2AIQ96KK567
Histone H2A type 2-C (Histone H2A-GL101) (Histone H2A/q)HIST2H2AC H2AFQQ1677767
Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)IGFBP2 BP2 IBP2P1806567
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)ITGB2 CD18 MFI7P0510767
Mannosyl-oligosaccharide glucosidase (EC (Processing A-glucosidase I)MOGS GCS1Q1372467
Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)STEAP3 TSAP6Q658P367
Nucleolar protein 58 (Nucleolar protein 5)NOP58 NOL5 NOP5 HSPC120Q9Y2X367
Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)FKBP2 FKBP13P2688567
Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)SERPINA5 PCI PLANH3 PROCIP0515467
Protein BRICK1 (BRK1)BRK1 C3orf10 HSPC300 MDS027Q8WUW167
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)G3BP2 KIAA0660Q9UN8667
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)FUS TLSP3563767
Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)SRSF9 SFRS9 SRP30CQ1324267
Sorting nexin-18 (SH3 and PX domain-containing protein 3B) (Sorting nexin-associated Golgi protein 1)SNX18 SH3PXD3B SNAG1Q96RF067
Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha)EIF2B1 EIF2BAQ1423267
Tumor protein D52 (Protein N8)TPD52P5532767
Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)ATG3 APG3 APG3LQ9NT6267
Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36)VPS36 C13orf9 EAP45 CGI-145Q86VN167
Aldehyde dehydrogenase family 1 member A3 (EC (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)ALDH1A3 ALDH6P4789566
Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin)AFP HPAFPP0277166
Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2)PARVA MXRA2Q9NVD766
Angiopoietin-related protein 2 (Angiopoietin-like protein 2)ANGPTL2 ARP2 UNQ170/PRO196Q9UKU966
Carboxypeptidase D (EC (Metallocarboxypeptidase D) (gp180)CPDO7597666
Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)CLDN4 CPER CPETR1 WBSCR8O1449366
Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A)FAM120A C9orf10 KIAA0183 OSSAQ9NZB266
Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)COX5BP1060666
Glycolipid transfer protein (GLTP)GLTPQ9NZD266
Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]ITM2C BRI3 hucep-14 NPD018 PSEC0047Q9NQX766
Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)LAMA1 LAMAP2539166
Lysosomal acid phosphatase (LAP) (EC
Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET)MANF ARMET ARPP5514566
Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]MAP1BP4682166
Microtubule-associated protein 4 (MAP-4)MAP4P2781666
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]CD14P0857166
Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205)NUP205 C7orf14 KIAA0225Q9262166
Proteasome inhibitor PI31 subunit (hPI31)PSMF1Q9253066
Ras-related protein Rab-2BRAB2BQ8WUD166
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)SMC2 CAPE SMC2L1 PRO0324O9534766
Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)SDC2 HSPG1P3474166
Testin (TESS)TESQ9UGI866
Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC
V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)ATP6AP1 ATP6IP1 ATP6S1 VATPS1 XAP3Q1590466
ATP synthase subunit f, mitochondrialATP5J2 ATP5JLP5613465
ATP-dependent RNA helicase DDX39A (EC (DEAD box protein 39) (Nuclear RNA helicase URH49)DDX39A DDX39O0014865
Caldesmon (CDM)CALD1 CAD CDMQ0568265
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC
Dedicator of cytokinesis protein 10 (Zizimin-3)DOCK10 KIAA0694 ZIZ3Q96BY665
Dipeptidase 1 (EC (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)DPEP1 MDP RDPP1644465
E3 ubiquitin-protein ligase TRIM23 (EC (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)TRIM23 ARD1 ARFD1 RNF46P3640665
Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]EIF2A CDA02 MSTP004 MSTP089Q9BY4465
Extended synaptotagmin-2 (E-Syt2) (Chr2Syt)ESYT2 FAM62B KIAA1228A0FGR865
Glypican-6 [Cleaved into: Secreted glypican-6]GPC6 UNQ369/PRO705Q9Y62565
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)HNRNPUL1 E1BAP5 HNRPUL1Q9BUJ265
Histone acetyltransferase type B catalytic subunit (EC (Histone acetyltransferase 1)HAT1 KAT1O1492965
Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein)FN3KRPQ9HA6465
Metallo-beta-lactamase domain-containing protein 2 (EC 3.-.-.-)MBLAC2Q68D9165
Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)HM13 H13 IMP1 PSL3 SPP MSTP086Q8TCT965
Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)MYL9 MLC2 MRLC1 MYRL2P2484465
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC (EC (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)NDUFS3O7548965
Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)PPID CYP40 CYPDQ0875265
Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)PPIH CYP20 CYPHO4344765
Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain]PRSS8Q1665165
Pyridoxine-5'-phosphate oxidase (EC (Pyridoxamine-phosphate oxidase)PNPOQ9NVS965
Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]LAMTOR4 C7orf59Q0VGL165
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)ARHGEF2 KIAA0651 LFP40Q9297465
Serpin B12SERPINB12Q96P6365
SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)UBA2 SAE2 UBLE1B HRIHFB2115Q9UBT265
Syntenin-2 (Syndecan-binding protein 2)SDCBP2 SITAC18Q9H19065
Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)F3P1372665
Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]PLATP0075065
Trypsin-2 (EC (Anionic trypsinogen) (Serine protease 2) (Trypsin II)PRSS2 TRY2 TRYP2P0747865
Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein)TNFAIP2Q0316965
WD repeat-containing protein 82 (Protein TMEM113) (Swd2)WDR82 TMEM113 WDR82A UNQ9342/PRO34047Q6UXN965
Casein kinase II subunit alpha' (CK II alpha') (EC CK2A2P1978464
Collagen alpha-2(V) chainCOL5A2P0599764
Complement factor I (EC (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]CFI IFP0515664
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)POLR2EP1938864
Ephrin type-B receptor 3 (EC (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)EPHB3 ETK2 HEK2 TYRO6P5475364
Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97)EIF4G2 DAP5 OK/SW-cl.75P7834464
Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)GPX3 GPXPP2235264
High mobility group protein B2 (High mobility group protein 2) (HMG-2)HMGB2 HMG2P2658364
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)HLA-DRA HLA-DRA1P0190364
Immunoglobulin kappa variable 3-11 (Ig kappa chain V-III region VG)IGKV3-11P0443364
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)IDH3AP5021364
Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta)LAMB3 LAMNB1Q1375164
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]NTMT1 C9orf32 METTL11A NRMT NRMT1 AD-003Q9BV8664
NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)NDFIP1 N4WBP5 PSEC0192 PSEC0223Q9BT6764
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)PUF60 FIR ROBPI SIAHBP1Q9UHX164
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