EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Deleted.0D1GND33
Deleted.0D1GP333
Deleted.0D1GRA93
Deleted.0E0TPP13
Deleted.0E0TLS73
Deleted.0E0TQ323
Deleted.0E0STZ53
Deleted.0E0SX643
Deleted.0B5E6033
Deleted.0B5E6T23
Deleted.0B5E4Y53
Deleted.0B8ZLN13
Deleted.0Q2MGF73
Deleted.0Q97NH73
Deleted.0E0TRH73
Deleted.0E0SYE43
Deleted.0C1CP013
Deleted.0D1GNE73
Deleted.0D1GSK03
Deleted.0D1GSK13
Deleted.0D1GSJ93
Deleted.0A0A025FZ313
Deleted.0A0A066T0N83
Deleted.0A0A0E3MW473
Deleted.0A0A0D8W0F43
Deleted.0A0A0X4ZZR03
Deleted.0A0A0D8VYX33
Deleted.0A0A0E3MX443
Deleted.0A0A075L8483
Deleted.0A0A0B0XAB53
Deleted.0A0A0E2U1Q63
Deleted.0A0A0F6GKK53
Deleted.0A0A0C2D9V73
Deleted.0A0A0D8VYJ93
Deleted.0A0A0D8VGY93
Deleted.0A0A0E3KE963
Deleted.0A0A075LGH13
Deleted.0H9UR613
Deleted.0A0A075LC573
Deleted.0A0A025GK563
Deleted.0A0A025FSQ03
Dihydrofolate reductase (EC 1.5.1.3)folA_1 folA EC3234A_2c00340 ERS085365_01073 ERS085366_00734 ERS085374_01814 ERS085379_00656 ERS085383_01301 ERS085386_01665 ERS085404_00833 ERS085406_00441 ERS085416_01539 ERS139211_00792 ERS139235_01236 ERS150873_00992 ERS150876_00187 FORC28_5155 MS6198_00560 PGD_03692 SK85_00048 SM09_00790A0A024L7M83
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of branched-chain alpha-keto acid dehydrogenase complex) (LPD-Val)lpdV PA2250Q9I1L93
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein)lpdA lpd b0116 JW0112P0A9P03
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2)sucB Smlt3198B2FLD23
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex)sucB b0727 JW0716P0AFG63
Dihydroorotase (DHOase) (EC 3.5.2.3)pyrC MXAN_3511Q1D6L83
Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase)pyrD ECONIH1_05980 MS6198_10880A0A0A1A6K23
Dihydropteroate synthase type-2 (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase type II) (Dihydropteroate synthase type II) (DHPS)sulIIP0AC113
Disulfide bond formation protein D (Disulfide oxidoreductase D) (Thiol-disulfide oxidoreductase D)bdbD yvgV BSU33480O322183
DNA binding regulator, beta subunit BhupB PP_2303Q88KI73
DNA polymerase I (EC 2.7.7.7)polA BX52_07305A0A0E2TN733
DNA protection during starvation protein (EC 1.16.-.-)dps Cj1534cQ0P8913
DNA repair protein RecN (Recombination protein N)recN PA4763Q9HV413
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)topA PA3011Q9HZJ53
DNA-binding proteinstpA Ec53638_3273A0A0E1T7B13
DNA-binding transcriptional regulator (DeoR faimly transcriptional regulator)BE932_26485 SY51_02935A0A061KSL23
DNA-directed DNA polymerase (EC 2.7.7.7)dnaE spr0795Q8DQ863
DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta)rpoB FTN_1568A0Q8673
DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta)rpoB Smlt0898B2FQ383
DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta)rpoB EcE24377A_4528A7ZUK13
DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta')rpoC FTN_1567A0Q8663
DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta')rpoC PP_0448Q88QP13
dTDP-glucose 4,6-dehydratase (EC 4.2.1.46)rffG A5958_09955 ACU57_26095 AMK83_07115 ERS085379_03211 UN86_04465 WQ89_13645 WR15_15375A0A061KPW23
DUF4432 domain-containing protein (Deoxyribose mutarotase)BMT53_10700 JD73_00530A0A085P7G23
ECF RNA polymerase sigma-E factor (RNA polymerase sigma-E factor) (Sigma-24)rpoE Z3855 ECs3439P0AGB83
EcoE type I restriction modification enzyme M subunit (EC 3.1.21.3)hsdM spr0449Q8DQX13
Ecotineco EL75_1424 EL79_1433 EL80_1455A0A090JLU13
Efem/EfeO family lipoprotein NMB0035NMB0035Q9K1P63
Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA)lepA EC958_2875 UG58_13975W8ZUS13
Elongation factor G (EF-G)fusA far fus b3340 JW3302P0A6M83
Elongation factor G (EF-G)fusA FTN_0237A0Q4I13
Elongation factor G (EF-G)fusA Cj0493Q9PI163
Elongation factor G (EF-G)fusA HP_1195P560023
Elongation factor G (EF-G)fusA Smlt0903B2FQ423
Elongation factor G 1 (EF-G 1)fusA fusA-1 PP_0451Q88QN83
Elongation factor G 2 (EF-G 2)fusB fusA2 PA2071Q9I2443
Elongation factor Ts (EF-Ts)tsf EcE24377A_0174A7ZHR03
Elongation factor Tu (EF-Tu)tufA tufA1 NMB0124; tufB tufA2 NMB0139P640273
Elongation factor Tu (EF-Tu)tuf FTN_1576A0Q8743
Elongation factor Tu (EF-Tu)tuf tufB Cj0470O693033
Elongation factor Tu (EF-Tu) (P-40)tuf tufA BSU01130P331663
Elongation factor Tu-A (EF-Tu-A)tufA tuf-1 PP_0440Q88QP83
Elongation factor Tu-B (EF-Tu-B)tufB tuf-2 PP_0452Q88QN73
Endolytic peptidoglycan transglycosylase RlpA (EC 4.2.2.-)rlpA PP_4804Q88DM13
Endolytic peptidoglycan transglycosylase RlpA (EC 4.2.2.-)rlpA HP_1571O260913
Endolytic peptidoglycan transglycosylase RlpA (EC 4.2.2.-)rlpA Smlt4051B2FUT33
Endolytic peptidoglycan transglycosylase RlpA (EC 4.2.2.-) (Rare lipoprotein A)rlpA PA4000Q9X6V63
Endonuclease MutS2 (EC 3.1.-.-)mutS2 spr0368Q8DR263
EndopeptidaseBX51_19210A0A025C7P33
Endopeptidase (Putative lipoprotein) (EC 3.4.-.-)nlpC AC067_17865 ACN77_27830 APU18_09625 AWP75_03785 BE932_03985 BK373_05010 BMT49_11120 ERS085366_03027 ERS085406_02850 GJ11_11670 MJ49_22805 PU06_10450 SY51_09515 WR15_13885E2QMR93
Endopeptidase La (EC 3.4.21.53)PA4576Q9HVK83
Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)eno Cj1672cP424483
Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)eno spr1036Q8DPS03
Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)eno BSU33900P378693
Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)eno EcE24377A_3083A7ZQM23
Esterase EstP (EC 3.1.1.1) (Autotransporter esterase EstP) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2)estP PP_0418Q88QS03
Fatty acid oxidation complex subunit alpha [Includes: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8)]fadB BE932_18600 SY51_21950A0A061K6E73
Fe(3+) dicitrate transport protein FecA (Iron(III) dicitrate transport protein FecA)fecA b4291 JW4251P130363
Fe/S biogenesis protein NfuAnfuA EcE24377A_3889A7ZSU33
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