EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
L-threonine 3-dehydrogenase (TDH) (EC A4T40_25510 BK334_24225 ECONIH1_21120 MS6198_41610A0A0A1AAF93
Lactonizing lipase (EC (Triacylglycerol lipase)lip lipA PA2862P268763
Large-conductance mechanosensitive channelmscL PP_4645Q88E233
Lipid A deacylase (EC (LPS 3-O-deacylase) (Outer membrane enzyme)pagL-II PP_3154Q88I473
Lipid A deacylase (EC (LPS 3-O-deacylase) (Outer membrane enzyme)pagL-I PP_0737Q88PW13
Lipopolysaccharide biosynthetic protein LpxO2lpxO2 PA0936Q9I5223
Lipopolysaccharide export system protein LptAlptA PA4460Q9HVV73
LipoproteinosmB E2348C_1475B7UR913
LipoproteinBE932_05435 SY51_10560A0A061YFP43
LipoproteinA4T40_18310 BK251_07215 BK292_15105 BK334_12765 BMT94_22310 BXT93_09620 ECONIH1_15155A0A023LHC83
Lipoprotein (Putative lipoprotein)A4T50_02175 ACN87_08960 APU18_08480 BE932_05830 ERS085406_02554 SY51_10960 WM48_09925A0A067HRK83
Lipoprotein required for swarmingyaiW PP_3805Q88GB93
Lipoprotein, Lppl familyPP_5226Q88CF53
Lipoprotein-releasing system ATP-binding protein LolD (EC 3.6.3.-)lolD E2348C_1209B7UPD33
Lon protease (EC (ATP-dependent protease La)lon PA1803Q9I2T93
Lon protease (EC (ATP-dependent protease La)lon c0555P0A9M13
Long-chain fatty acid outer membrane transporter (Long-chain fatty acid transporter)BE932_09340 SY51_13360A0A061L3833
Long-chain fatty acid transport protein (Outer membrane FadL protein) (Outer membrane flp protein)fadL ttr b2344 JW2341P103843
Long-chain fatty acid transport protein (Outer membrane FadL protein) (Outer membrane flp protein)fadL Z3608 ECs3227Q8XCN63
Low specificity L-threonine aldolase (Low-specificity L-threonine aldolase) (Threonine aldolase)ltaE A4T40_08110 BK248_26155 BK334_18400 ECONIH1_05190 MS6198_09970A0A0A1A3H63
LPS biosynthesis protein WbpGwbpG PA3150Q9HZ783
LPS-assembly lipoprotein LptElptE PP_4795Q88DN03
LPS-assembly lipoprotein LptElptE Smlt3484B2FPR63
LPS-assembly protein LptDlptD imp ostA FTN_0558A0Q5D83
Lysine / arginine / ornithine ABC transporter-periplasmic binding protein (EC PP_4486Q88EH73
Lysine decarboxylase 1 (EC (Lysine decarboxylase LdcC) (Lysine decarboxylase, inducible)cadA A4T40_01970 A4T50_15395 APU18_25275 BE932_20420 BK248_25250 BK334_08360 BK373_03500 ECONIH1_24620 ERS085406_00149 MJ49_08650 MS6198_48510 SY51_23835 WM48_22955E2QK233
Lysine decarboxylase, constitutive (EC Ec53638_1623A0A0E1T7F73
Lysine--tRNA ligase (EC (Lysyl-tRNA synthetase) (LysRS)lysS c3469P0A8N43
Lysophosphatidic acid acyltransferase, LptAlptA PA0005Q9I7C13
LysR family transcriptional regulator YdcIydcI ECRM12581_9730A0A023YXB33
M13 family metallopeptidasepepO FTN_1186A0Q7573
Macrolide 2'-phosphotransferase I (Macrolide 2'-phosphotransferase I Mph(A)) (Macrolide 2'-phosphotransferase Mph(A)) (Macrolide 2-phosphotransferase) (Macrolide 2-phosphotransferase protein, macrolide resistance protein) (Macrolide-phosphotransferase, mph(A)) (Mph(A)) (Mph(A) family macrolide 2'-phosphotransferase) (Mph(A) macrolide 2'-phosphotransferase I) (Phosphotransferase enzyme family protein)mphA mph(A) mph2 A9R57_28020 ACN77_02565 ACN77_03820 ACN77_19735 APT94_14590 APZ14_31330 AZ95_0038 BE932_01825 BE963_00520 BET08_23470 BJJ90_27660 BK248_28265 BK292_28790 BK334_26695 BK337_25500 BK373_25655 BK375_28440 BK383_16405 BK400_25080 ECONIH1_26770 ERS085366_04054 ERS150873_04753 ETN48_p0083 HMPREF3040_01642 MS6198_B122 orf00017 pCTXM123_C0996_11 pKC394-009 UN86_19875Q473963
Magnesium and cobalt efflux protein CorCcorC Ec53638_0656A0A0E1SW843
Magnesium and cobalt transportercorA spr0170Q8DRE53
Major outer membrane lipoproteinoprI PP_2322Q88KG83
Major outer membrane lipoprotein Lpp (Braun lipoprotein) (Murein-lipoprotein)lpp mlpA mulI b1677 JW1667P697763
Major outer membrane protein (Porin)porA Cj1259P806723
Major outer membrane protein P.IB (PIB) (Protein IB) (Class 3 protein) (Porin)porB NMB2039P306903
Malate dehydrogenase (EC b3236 JW3205P618893
Malate dehydrogenase (EC Smlt0944B2FQL83
Malate dehydrogenase (EC EcE24377A_3719A7ZSD03
Malate synthase G (EC E2348C_3255B7UI433
Malate synthase G (EC ECRM12581_19065A0A023Z2F83
Maltoporin (Maltose-inducible porin)lamB E2348C_4351B7UPJ73
Maltose ABC transporter substrate-binding protein MalE (Sugar ABC transporter substrate-binding protein)malE BE932_19685 SY51_23190A0A061KYM23
Maltose-binding periplasmic protein (MBP) (MMBP) (Maltodextrin-binding protein)malE b4034 JW3994P0AEX93
MarR-family transcriptional repressor (Transcriptional repressor MprA)mprA A5958_16620 ACN81_20455 AMK83_10095 ERS085379_00737 UN86_27085A0A066RG483
Membrane proteinBE932_10840 SY51_14895A0A061YH683
Membrane protein (Putative lipoprotein)A5958_09835 ACN81_24130 AM270_17720 AMK83_06995 AML07_08055 APZ14_07980 AUS26_17040 BMT53_14620 ERS085379_03176 ERS150876_04224 FORC28_5981 RG28_24355 UN86_04585 WQ89_13525A0A066R6Q93
Membrane-bound lytic murein transglycosylase A (EC 4.2.2.n1) (Mlt38) (Murein hydrolase A)mltA mlt ygdM b2813 JW2784P0A9353
Metallopeptidase, M23B subfamilyPP_1622Q88ME93
Methionine ABC transporter, periplasmic binding proteinmetQ PP_0112Q88RL73
Methionine import ATP-binding protein MetN 2 (EC 3.6.3.-)metN2 PA5503Q9HT703
Methionine--tRNA ligase (EC (Methionyl-tRNA synthetase) (MetRS)metG E2348C_2260B7UFD13
Methionine-binding lipoprotein MetQmetQ yusA BSU32730O321673
Methyl-accepting chemotaxis protein PA2652PA2652Q9I0I63
Methyl-accepting chemotaxis protein PctBpctB PA4310Q9HW913
Mg(2+) transport ATPase, P-type 2mgtA PA4825Q9HUY53
MltA-interacting proteinmipA yeaF b1782 JW1771P0A9083
Modulator of drug activity BmdaB Z4379 ECs3910P0AEY73
Molybdenum cofactor biosynthesis protein BmoaB AC789_1c08160 ACN002_0815 ACN77_24960 ACN81_02245 AML07_09330 APZ14_17870 AUS26_14775 BK251_08035 BK292_21500 BN17_05811 ERS139235_01854 ERS150876_00452 FORC28_4120 HW42_07735 PU06_03865 RG28_00620 WQ89_23285J7QYX73
Molybdenum cofactor biosynthesis protein BmoaB Z1001 ECs0860P0AF003
Molybdochelatase incorporating molybdenum into molybdopterinmogA CE10_0008A0A0E0V0853
Molybdopterin containing oxidoreductaseCj0264cQ0PBP13
Multidrug efflux systemacrA ECED1_0486B7MQH83
Multifunctional CCA protein [Includes: 2'-nucleotidase (EC 3.1.3.-); 2',3'-cyclic phosphodiesterase (EC 3.1.4.-); CCA-adding enzyme (EC (tRNA nucleotidyltransferase) (CCA tRNA nucleotidyltransferase) (tRNA adenylyl-/cytidylyl-transferase) (tRNA CCA-pyrophosphorylase) (tRNA-NT); Phosphatase]cca BE932_14180 SY51_17725A0A066SX663
Multifunctional fusion protein [Includes: DNA-directed RNA polymerase subunit; DNA-directed RNA polymerase subunit beta (EC]TTRE_0000800301A0A077ZM273
N-6 DNA methylaseSY51_01550A0A066SWZ83
N-acetyl-D-glucosamine kinase (EC (GlcNAc kinase)nagK BE932_29810 SY51_06160A0A061L1N03
N-acetylglucosamine-6-phosphate deacetylase (EC nagA_1 A4T40_06985 A4T50_18240 APT94_14370 APU18_23680 BE932_26975 BE963_17530 BK248_02830 BK334_19080 BK373_00070 BMT49_04940 BMT91_15565 BMT97_22520 ECONIH1_03820 ERS085406_01622 GJ11_03675 HMPREF3040_04637 MJ49_03225 MS6198_07300 SM09_01486 SY51_03400 WM48_03495A0A061KPP83
N-acetylmuramoyl-L-alanine amidaseamiB PA4947Q9HUL73
N-acetylmuramoyl-L-alanine amidase (EC PP_4897Q88DD03
N-acetylmuramoyl-L-alanine amidase (N-acetylmuramoyl-L-alanine amidase AmiA) (N-acetylmuramoyl-l-alanine amidase I)amiA A4T40_17440 APT94_12785 BE949_09710 BIQ85_13775 BK248_17165 BK334_04155 BK373_06330 BK383_23640 BMT97_19265 BUE82_06370 BXT93_01890 ECONIH1_14005 HMPREF3040_04896 MJ49_18690 MS6198_27580 SM09_02588A0A023L0H53
N-acetylneuraminate lyase (NAL) (Neu5Ac lyase) (EC (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialic acid aldolase) (Sialic acid lyase)nanA BY96_04275A0A027U3Z53
N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC (5-(carboxyamino)imidazole ribonucleotide synthetase)purK A9R57_25690 BHS87_02825 BJJ90_19630 BW690_15560 ERS085365_04381 ERS085416_04151 ERS139211_04464 ERS150873_03918 PGD_02791A0A024L6J73
NAD(P)-dependent oxidoreductase (Short-chain dehydrogenase)AKG99_14870 BHF46_01090 BMT61_05540 BMT91_11820 JD73_18240A0A085P1L73
NAD+ dependent aldehyde dehydrogenase ExaCexaC PA1984Q9I2C43
NAD-dependent succinate-semialdehyde dehydrogenase (Succinate-semialdehyde dehydrogenase) (EC BE932_11225 SY51_14980A0A061YGG73
NADH dehydrogenase-like protein YjlD (EC 1.6.99.-) (Glucose starvation-inducible protein 5) (GSI5)yjlD BSU12290P808613
NADH-quinone oxidoreductase (EC FTN_1674A0Q8G63
NADH-quinone oxidoreductase (EC A4T50_04465 AML35_07635 APU18_03185 BE932_09015 BE963_27215 BHF46_01735 BK248_00865 BK373_07045 BK375_19570 BK383_00255 BMT49_14700 BMT94_02690 BMT97_08490 BUE82_07125 ERS085386_00209 JD73_19290 MJ49_19400 SM09_02402 SY51_13060A0A023LCA93
NADH-quinone oxidoreductase subunit B (EC (NADH dehydrogenase I subunit B) (NDH-1 subunit B)nuoB PA2638Q9I0K03
NADH-quinone oxidoreductase subunit C (EC (NADH dehydrogenase I subunit C) (NDH-1 subunit C)nuoC Smlt3403B2FNX73
NADH-quinone oxidoreductase subunit D (EC (NADH dehydrogenase I subunit D) (NDH-1 subunit D)nuoD FTN_1677A0Q8G93
NADH-quinone oxidoreductase subunit F (EC AC789_1c26350A0A0E1LC253
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC spr1028Q8DPS73
NADP-dependent malic enzyme (NADP-ME) (EC ypfF b2463 JW2447P765583
Negative modulator of initiation of replicationseqA A4T50_18340 BE932_27080 SY51_03505A0A061KQD63
Ni/Fe-hydrogenase large subunit (EC Cj1266cQ0P8Z03
Ni/Fe-hydrogenase small chain (EC Cj1267cQ0P8Y93
Nicotinate phosphoribosyltransferase (EC
Nitrate reductase alpha chain (EC BSU37280P421753
Nitrate reductase beta chain (EC BSU37270P421763
Nitrogen regulation protein NR(I)glnG BY96_18755A0A027TPV13
Nitrogen regulatory protein P-II (Nitrogen regulatory protein P-II 1) (Transcriptional regulator)glnB AC067_03135 AWP75_06510 BMT61_04910 EL75_1094 EL79_1105 EL80_1108 PGD_00683A0A024KZV83
Non-specific ribonucleoside hydrolase RihC (EC 3.2.-.-) (Purine/pyrimidine ribonucleoside hydrolase)rihC BE932_23165 SY51_00155A0A066SP863
NrdJanrdJa PA5497Q9HT763
Nucleoid-associated protein YejKyejK BY96_25240A0A027U6933
Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC (Nucleoside-2-P kinase)ndk EcE24377A_2802A7ZPW13
Nucleoside-specific channel-forming protein tsxtsx nupA b0411 JW0401P0A9273
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