EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Lon protease (EC 3.4.21.53) (ATP-dependent protease La)lon NGO_0775Q5F8J84
LPS-assembly lipoprotein LptElptE NGO_0282Q5F9V64
LPS-assembly protein LptDlptD imp ostA NGO1715Q5F6514
Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)lysS NGO1454Q5F6U24
Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)lysS PA3700Q9HXU04
Lysine-specific pyridoxal 5'-phosphate-dependent carboxylase, LdcAldcA PA1818Q9I2S74
Lysozyme inhibitorA4T40_12855 AC067_17495 APT94_06095 APU18_09985 AWP75_03415 BE932_03615 BE949_04670 BIQ85_09400 BK248_09565 BK334_14445 BK375_03325 BK383_06975 BUE82_10830 BXT93_13565 ECONIH1_09530 GJ11_11300 HMPREF3040_05297 SY51_09155 UC41_05625A0A066SZP24
Lytic murein transglycosylaseNGO_2135Q5F5054
M18 family aminopeptidase (EC 3.4.11.-)MXAN_2382Q1D9S14
Major ferric iron-binding protein (FBP) (Iron(III) periplasmic-binding protein) (Major iron-regulated protein) (MIRP)fbpA fbp NMB0634P0A0Y44
Major fimbrial subunit SMF-1 (S. maltophilia fimbriae 1) (SMF-1)smf-1 Smlt0706B2FNJ04
Malate synthase (EC 2.3.3.9)BE932_19535 SY51_23045A0A061L2B24
Malonic semialdehyde reductaseNGO_1079Q5F7U14
Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)NGO_2166Q5F4X74
Maltoporin (Lambda receptor protein) (Maltose-inducible porin)lamB malB b4036 JW3996P029434
Maltose/maltodextrin-binding proteinmalX spr1918P592144
Manganese-binding lipoprotein mntALMRG_00994A0A0H3GDS94
Manganese/iron transport system ATP-binding proteinLMRG_00996A0A0H3GD684
Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)mtlD BK373_22890 MJ49_12185 SY51_20545A0A066TAS44
Mannose-6-phosphate isomerase (EC 5.3.1.8)BE932_03465 SY51_09010A0A066T0E24
Mannose-specific PTS system IID componentLMRG_02347A0A0H3GGW34
Matrix-associated zinc metalloprotease FibAfibA MXAN_6106Q1CZD24
Membrane proteinNGO_1812Q5F5V74
Membrane proteinNGO_1577Q5F6I14
Membrane proteinNGO_0233Q5FA014
Membrane proteinNGO_1802Q5F5W74
Membrane proteinNGO_0994Q5F8094
Membrane proteinNGO_1956Q5F5H04
Membrane proteinNGO_0868Q5F8B84
Membrane proteinNGO_0648Q5F8W24
Membrane proteinNGO_1559Q5F6J54
Membrane proteinNGO_0834Q5F8E44
Membrane proteinNGO_0413Q5F9I14
Membrane proteinNGO_0778Q5F8J54
Membrane proteinNGO_1958Q5F5G84
Membrane proteinNGO_1688Q5F6744
Membrane proteinMJ49_11300 SY51_21055 WM48_20405A0A061YGY84
Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC)yidC NGO2178Q5F4W64
Membrane-bound lysozyme-inhibitor of c-type lysozyme family proteinNGO_1063Q5F7V44
Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M)map Ec53638_1143A0A0E1T1844
Methionyl-tRNA formyltransferase (EC 2.1.2.9)fmt NGO1870Q5F5P74
Methionyl-tRNA formyltransferase (EC 2.1.2.9)fmt A4T40_22135 BK334_26360 ECONIH1_19360 MS6198_38020A0A0A1ADD04
Methyl-accepting chemotaxis protein PctCpctC PA4307Q9HW934
Molybdenum-pterin-binding protein MopA (Molybdenum-pterin-binding-protein) (Transporter)mopA modE_2 AML35_05550 APT94_21275 APU18_18795 BE932_11605 BE949_27170 BE963_03400 BET08_27250 BHF46_04795 BK248_12735 BK334_12275 BK373_16140 BMT97_02885 BXT93_17980 ECONIH1_15655 ERS085406_04261 GJ11_17750 JD73_16590 MJ49_17365 MS6198_30380 SY51_15360 WM48_14690A0A023LDF94
MORN repeat variant family proteinNGO_1299Q5F7844
Multidrug efflux pump channel proteinmtrE NMB1714Q9JY684
Multidrug transporterNGO_1363Q5F7264
Multidrug transporterNGO_1365Q5F7244
Multiple sugar transport system substrate-binding proteinLMRG_02746A0A0H3GCT34
Murein transglycosylaseNGO_2048Q5F5814
Murein transglycosylaseNGO_0608Q5F9014
Murein transglycosylaseNGO_0626Q5F8Y34
N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38) (N-acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase)argC NGO0118Q5FAA94
N-acetylmuramoyl-L-alanine amidaseamiC NGO_1502Q5F6P74
N-acetylmuramoyl-L-alanine amidase (N-acetylmuramoyl-L-alanine amidase amid)BE932_28035 SY51_04440 WM48_04475E2QIN34
N-succinylarginine dihydrolase (EC 3.5.3.23)astB APU18_09440 BE932_04180 SY51_09700A0A061KX904
NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog)cobB AUQ13_23145 BET08_21805 BK337_22035 BUE81_15995 EC3234A_26c00910A0A0A6S7A24
NADH dehydrogenaseLMRG_02183A0A0H3GG154
NADH-quinone oxidoreductase subunit C/D (EC 1.6.5.11) (NADH dehydrogenase I subunit C/D) (NDH-1 subunit C/D)nuoC nuoCD nuoD EcE24377A_2579A7ZPA04
NADH-quinone oxidoreductase subunit F (EC 1.6.5.11) (NADH dehydrogenase I subunit F) (NDH-1 subunit F)nuoF PA2641Q9I0J74
NADPH-dependent 7-cyano-7-deazaguanine reductase (EC 1.7.1.13) (7-cyano-7-carbaguanine reductase) (NADPH-dependent nitrile oxidoreductase) (PreQ(0) reductase)queF NGO1684Q5F6784
Nitrite reductase (EC 1.7.2.1) (Cytochrome cd1) (Cytochrome oxidase) (Hydroxylamine reductase) (EC 1.7.99.1)nirS PA0519P244744
Octaprenyl diphosphate synthase (EC 2.5.1.90) (All-trans-octaprenyl-diphosphate synthase) (Octaprenyl pyrophosphate synthase) (OPP synthase)ispB cel yhbD b3187 JW3154P0AD574
Oligopeptide transport ATP-binding protein oppFLMRG_01640A0A0H3GER94
Oligopeptide transporter subunitoppA CE10_1421A0A0E0V3U54
Oligoribonuclease (EC 3.1.-.-)orn WRSd3_02570A0A090NFF24
Opacity protein opA54NGO_1513Q5F6N64
Osmotically inducible lipoprotein E (Transcriptional regulator)osmE A4T50_01185 APU18_09475 BE932_04150 BK373_05160 ERS085406_02820 MJ49_22655 SY51_09665 WM48_08885E2QMU74
Outer membrane protein A (Outer membrane protein II*)ompA con tolG tut b0957 JW0940P0A9104
Outer membrane protein assembly factor BamAbamA NGO_1801Q5F5W84
Outer membrane protein assembly factor BamBbamB Smlt2059B2FNR04
Outer membrane protein assembly factor BamDbamD NGO_0277Q5F9W04
Outer membrane protein assembly factor BamDcomL bamD Smlt3748B2FRR94
Outer membrane protein assembly factor BamD (Competence lipoprotein ComL)bamD comL NMB0703Q9K0B14
Outer membrane protein assembly factor BamEbamE omlA oprX PA4765O685624
Outer membrane protein assembly factor BamEbamE NGO_1780Q5F5Y84
Outer membrane protein C (Outer membrane protein 1B) (Porin OmpC)ompC meoA par b2215 JW2203P069964
Outer membrane protein NspAnspA NMB0663Q7DDM24
Outer membrane protein XompX ybiG b0814 JW0799P0A9174
Outer-membrane lipoprotein LolBlolB NMB0873P570244
Outer-membrane lipoprotein LolBlolB hemM PA4668P428124
OxidoreductaseNGO_0624Q5F8Y54
OxidoreductaseNGO_0197Q5FA374
OxidoreductaseBE932_25710 SY51_02195A0A061YF334
Patatin-like protein, PlpDplpD PA3339Q9HYQ64
Penicillin binding protein 1ALMRG_01039A0A0H3GDX64
Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]mrcA ponA PA5045Q078064
Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]mrcA NGO0099Q5FAC74
Penicillin-binding protein 1b (EC 2.3.2.-) (EC 2.4.1.129)pbp1b spr1909Q7CRA44
PeptidaseNGO_1056Q5F7W04
PeptidaseNGO_0275Q5F9W24
PeptidaseNGO_1375Q5F7144
Peptidase M23NGO_1686Q5F6764
Peptidase PmbApmbA NGO_0411Q5F9I34
Peptidase propeptide and ypeb domain-containing proteinLMRG_01045A0A0H3GLF44
Peptidase S41NGO_0572Q5F9324
Peptidase, M10A/M12A subfamilies (EC 3.4.24.-)MXAN_0805Q1DE554
Peptidase, S8 (Subtilisin) family (EC 3.4.21.-)MXAN_5970Q1CZR84
Peptide chain release factor 3 (RF-3)prfC NGO0209Q5FA254
Peptide chain release factor 3 (RF-3)prfC spr0396Q8DR094
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