EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]CFLAR CASH CASP8AP1 CLARP MRITO155198
Caveolin-2CAV2P516368
Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG-2)CITED4 MRG2Q96RK18
CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)CD151 TSPAN24P485098
CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (Protein HSF-27)CDK5RAP3 IC53 MSTP016 OK/SW-cl.114 PP1553Q96JB58
Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein)CDC5L KIAA0432 PCDC5RPQ994598
Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1)CENPM C22orf18 ICEN39 PANE1Q9NSP48
Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)ITGB3BP CENPR NRIF3Q133528
Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa)APITD1 CENPS FAAP16 MHF1Q8N2Z98
Centrosomal protein of 63 kDa (Cep63)CEP63Q96MT88
Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1Q9HD428
Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa)BAP18 C17orf49Q8IXM28
Chromodomain Y-like protein (CDY-like) (EC 2.3.1.48)CDYL CDYL1Q9Y2328
Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein)CHD9 KIAA0308 KISH2 PRIC320 AD-013 x0008Q3L8U18
Chromosome 12 open reading frame 10 (Chromosome 12 open reading frame 10, isoform CRA_b)C12orf10 hCG_23362Q86UA38
Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12)CHTF18 C16orf41 CTF18Q8WVB68
CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7)CMTM7 CKLFSF7Q96FZ58
Claudin domain-containing protein 2CLDND2Q8NHS18
Claudin-14CLDN14 UNQ777/PRO1571O955008
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CFIm25) (CPSF 25 kDa subunit) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Pre-mRNA cleavage factor Im 25 kDa subunit)NUDT21 CFIM25 CPSF25 CPSF5O438098
Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)COPEO145798
Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2)STAG2 SA2Q8N3U48
Coiled-coil domain-containing protein 130 (9 kDa protein)CCDC130 SB115P139948
Coilin (p80)COIL CLN80P384328
Collagen alpha-2(IX) chainCOL9A2Q140558
COMM domain-containing protein 3 (Protein Bup) (Protein PIL)COMMD3 BUP C10orf8Q9UBI18
COMM domain-containing protein 6COMMD6 MSTP076Q7Z4G18
Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP)C1QTNF1 CTRP1 UNQ310/PRO353Q9BXJ18
Complement C1q tumor necrosis factor-related protein 6C1QTNF6 CTRP6 UNQ581/PRO1151Q9BXI98
Complement decay-accelerating factor (CD antigen CD55)CD55 CR DAFP081748
Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2)NCAPH2 CAPH2Q6IBW48
Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B)FAM120B CCPG KIAA1838Q96EK78
Copine-3 (Copine III)CPNE3 CPN3 KIAA0636O751318
Copper transport protein ATOX1 (Metal transport protein ATX1)ATOX1 HAH1O002448
CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard)CTDNEP1 DULLARDO954768
CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)CTPS2Q9NRF88
Cullin-4B (CUL-4B)CUL4B KIAA0695Q136208
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)CUL5 VACM1Q930348
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)CDK1 CDC2 CDC28A CDKN1 P34CDC2P064938
Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R)CDK2AP2 DOC1RO759568
Cyclin-dependent kinase 5 activator 2 (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (p39) (p39I)CDK5R2 NCK5AIQ133198
Cyclin-L1 (Cyclin-L)CCNL1 BM-001 UNQ530/PRO1073Q9UK588
Cysteine-rich protein 2 (CRP-2) (Protein ESP1)CRIP2 CRP2P529438
Cysteine-rich with EGF-like domain protein 1CRELD1 CIRRIN UNQ188/PRO214Q96HD18
Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)CDA CDDP323208
Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)UQCRC1P319308
Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein)UQCR10 UCRC HSPC119Q9UDW18
Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L)COX6A1 COX6ALP120748
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)CYFIP1 KIAA0068Q7L5768
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)CYFIP2 KIAA1168 PIR121Q96F078
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)NCK2 GRB4O436398
Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63)CKAP4Q070658
Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (ATP/GTP-binding protein-like 5)AGBL5 CCP5Q8NDL98
DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)DCAF5 BCRG2 KIAA1824 WDR22Q96JK28
Desumoylating isopeptidase 2 (DeSI-2) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)DESI2 C1orf121 FAM152A PPPDE1 CGI-146 PNAS-4Q9BSY98
Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta)DGKZ DAGK6Q135748
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)DPYSL2 CRMP2 ULIP2Q165558
Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase)GNPAT DAPAT DHAPATO152288
Diphthamide biosynthesis protein 2 (DPH2 homolog) (HsDph2) (Diphthamide biosynthesis protein 2 homolog-like 2) (DPH2-like 2)DPH2 DPH2L2Q9BQC38
Disco-interacting protein 2 homolog A (DIP2 homolog A)DIP2A C21orf106 DIP2 KIAA0184Q146898
DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)DDIT4 REDD1 RTP801Q9NX098
DNA polymerase delta subunit 2 (EC 2.7.7.7) (DNA polymerase delta subunit p50)POLD2P490058
DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)POLR1BQ9H9Y68
DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)POLR2G RPB7P624878
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15)POLR2F POLRFP612188
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)POLR2HP524348
DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)DNAJB1 DNAJ1 HDJ1 HSPF1P256858
DNCL1 protein (Dynein, light chain, LC8-type 1) (Dynein, light chain, LC8-type 1, isoform CRA_a) (cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA)DNCL1 DYNLL1 hCG_27767Q6FGH98
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)MAP2K5 MEK5 MKK5 PRKMK5Q131638
Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)DUSP1 CL100 MKP1 PTPN10 VH1P285628
Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3)DUSP5 VH3Q166908
Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5)DUSP8 C11orf81 VH5Q132028
Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B)CDC14BO607298
Dynamin-2 (EC 3.6.5.5)DNM2 DYN2P505708
Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein)DTNBP1 BLOC1S8 My031Q96EV88
E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)PIAS2 PIASXO759288
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 6.3.2.-) (Triad1 protein)ARIH2 ARI2 TRIAD1 HT005O953768
E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin RING finger protein 1) (RING finger protein 156)MGRN1 KIAA0544 RNF156O602918
E3 ubiquitin-protein ligase RBX1 (EC 6.3.2.-) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed]RBX1 RNF75 ROC1P628778
E3 ubiquitin-protein ligase RNF13 (EC 6.3.2.-) (RING finger protein 13)RNF13 RZFO435678
E3 ubiquitin-protein ligase RNF14 (EC 6.3.2.-) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) (Triad2 protein)RNF14 ARA54 HRIHFB2038Q9UBS88
E3 ubiquitin-protein ligase RNF187 (EC 6.3.2.-) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187)RNF187Q5TA318
E3 ubiquitin-protein ligase RNF34 (EC 6.3.2.-) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF)RNF34Q969K38
E3 ubiquitin-protein ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)SIAH1 HUMSIAHQ8IUQ48
EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B)EFCAB4A CRACR2BQ8N4Y28
ELM2 and SANT domain-containing protein 1ELMSAN1 C14orf117 C14orf43Q6PJG28
Elongator complex protein 6 (Angiotonin-transactivated protein 1) (Protein TMEM103)ELP6 ATP1 C3orf75 TMEM103Q0PNE28
Enhancer of rudimentary homologERHP840908
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)EPHA3 ETK ETK1 HEK TYRO4P293208
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKEQ083458
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)EPN1Q9Y6I38
ER membrane protein complex subunit 6 (Transmembrane protein 93)EMC6 TMEM93Q9BV818
Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein)ESPN DFNB36 LP2654B1AK538
Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Placental 17-beta-hydroxysteroid dehydrogenase)HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17P140618
ETS domain-containing protein Elk-1ELK1P194198
ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)ERFP505488
ETS-related transcription factor Elf-1 (E74-like factor 1)ELF1P325198
ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor)ELF2 NERFQ157238
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog)GSPT1 ERF3AP151708
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)ETF1 ERF1 RF1 SUP45L1P624958
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