EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
E3 ubiquitin-protein ligase MARCH2 (EC 6.3.2.-) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172)MARCH2 RNF172 HSPC240Q9P0N811
E3 ubiquitin-protein ligase RING1 (EC 6.3.2.-) (Polycomb complex protein RING1) (RING finger protein 1) (Really interesting new gene 1 protein)RING1 RNF1Q0658711
E3 ubiquitin-protein ligase RNF220 (EC 6.3.2.-) (RING finger protein 220)RNF220 C1orf164Q5VTB911
Elongation factor 1-alphaEEF1A1 hCG_2033271Q6IPS911
Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH)ECHS1P3008411
EP300-interacting inhibitor of differentiation 1 (21 kDa pRb-associated protein) (CREBBP/EP300 inhibitory protein 1) (E1A-like inhibitor of differentiation 1) (EID-1)EID1 C15orf3 CRI1 RBP21 PNAS-22 PTD014Q9Y6B211
Epididymal secretory protein E1 (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein)NPC2 HE1P6191611
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)EIF3C EIF3S8Q9961311
Extended synaptotagmin-2 (E-Syt2) (Chr2Syt)ESYT2 FAM62B KIAA1228A0FGR811
Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)FOLR1 FOLRP1532811
Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)FOXC1 FKHL7 FREAC3Q1294811
Forkhead box protein J3FOXJ3 KIAA1041Q9UPW011
Forkhead box protein N3 (Checkpoint suppressor 1)FOXN3 C14orf116 CHES1O0040911
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)GRK6 GPRK6P4325011
G-protein coupled receptor 56 (Protein TM7XN1) [Cleaved into: GPR56 N-terminal fragment (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); GPR56 C-terminal fragment (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083Q9Y65311
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)CCND1 BCL1 PRAD1P2438511
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)LGALS1P0938211
Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)GJC1 GJA7P3638311
GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1)GAS2L1 GAR22Q9950111
Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)G6PDP1141311
Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)GLRX5 C14orf87Q86SX611
Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1)GNL1 HSR1P3691511
HCG26477 (Ribosomal protein S28, isoform CRA_a) (cDNA, FLJ92192, Homo sapiens ribosomal protein S28 (RPS28), mRNA)RPS28 hCG_23961 hCG_26477B2R4R911
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)HSPH1 HSP105 HSP110 KIAA0201Q9259811
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)HNRNPK HNRPKP6197811
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120)HNRNPU HNRPU SAFA U21.1Q0083911
High mobility group protein B2 (High mobility group protein 2) (HMG-2)HMGB2 HMG2P2658311
Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)HAT1 KAT1O1492911
Histone H2A.J (H2a/j)H2AFJQ9BTM111
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP)SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069Q9BYW211
HLA class I histocompatibility antigen, Cw-7 alpha chain (MHC class I antigen Cw*7)HLA-C HLACP1032111
Homer protein homolog 2 (Homer-2) (Cupidin)HOMER2Q9NSB811
Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)HAGH GLO2 HAGH1Q1677511
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)HPRT1 HPRTP0049211
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)KPNA4 QIP1O0062911
Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)IGFBP4 IBP4P2269211
Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]ITM2C BRI3 hucep-14 NPD018 PSEC0047Q9NQX711
Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK)ILK ILK1 ILK2Q1341811
Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16)IFI6 G1P3P0991211
Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20)ISG20 HEM45Q96AZ611
Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)IDH2P4873511
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)IDH3GP5155311
Keratin-associated protein 1-1 (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7)KRTAP1-1 B2A KAP1.1 KAP1.6 KAP1.7 KRTAP1.1Q0762711
Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9)KRTAP1-3 B2B KAP1.2 KAP1.3 KAP1.8 KAP1.9 KRATP1.9 KRTAP1.8Q8IUG111
Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12)KRTAP4-12 KAP4.12 KRTAP4.12Q9BQ6611
Keratinocyte-associated protein 2 (KCP-2)KRTCAP2 KCP2Q8N6L111
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)KHDRBS1 SAM68Q0766611
La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6)LARP6Q9BRS811
Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)GLO1Q0476011
Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA)LAD1 LADO0051511
LanC-like protein 1 (40 kDa erythrocyte membrane protein) (p40)LANCL1 GPR69AO4381311
Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)LSS OSCP4844911
Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)LRRFIP2Q9Y60811
Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a)LILRB3 ILT5 LIR3O7502211
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)LITAF PIG7 SIMPLEQ9973211
LSM domain-containing protein 1 (Phosphonoformate immuno-associated protein 2)LSMD1 MAK31 PFAAP2Q9BRA011
Major centromere autoantigen B (Centromere protein B) (CENP-B)CENPBP0719911
MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)MARCKSL1 MLP MRPP4900611
Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)MNT BHLHD3 ROXQ9958311
Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)MED16 DRIP92 THRAP5Q9Y2X011
Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX)MT1XP8029711
Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)MBD4 MED1O9524311
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)CLNS1A CLCI ICLNP5410511
Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)MITF BHLHE32O7503011
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)MAP1LC3B MAP1ALC3Q9GZQ811
Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)TOMM40 C19orf1 PEREC1 TOM40O9600811
Mitochondrial pyruvate carrier 1 (Brain protein 44-like protein)MPC1 BRP44L CGI-129 HSPC040 PNAS-115Q9Y5U811
Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)MFN2 CPRP1 KIAA0214O9514011
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1Q9Y6R411
MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B)MOB1A C2orf6 MOB4B MOBK1B MOBKL1BQ9H8S911
Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Protein MSL3-1) (Transcription factor-like protein MRG15)MORF4L1 MRG15 FWP006 HSPC008 HSPC061 PP368Q9UBU811
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)SMAD5 MADH5Q9971711
Myb/SANT-like DNA-binding domain-containing protein 3MSANTD3 C9orf30 L8Q96H1211
Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801)MAZ ZNF801P5627011
N-alpha-acetyltransferase 10 (EC 2.3.1.-) (EC 2.3.1.88) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit)NAA10 ARD1 ARD1A TE2P4122711
NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1)NQO1 DIA4 NMOR1P1555911
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit)NDUFB3O4367611
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit)NDUFV2P1940411
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)NAE1 APPBP1 HPP1Q1356411
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (55 kDa nuclear protein) (DNA-binding p52/p100 complex, 52 kDa subunit) (NMT55) (p54(nrb)) (p54nrb)NONO NRB54Q1523311
Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A)NSMCE4A C10orf86 PP4762Q9NXX611
Nucleolin (Protein C23)NCLP1933811
Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)PPIGQ1342711
Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140)BRPF1 BR140P5520111
Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17)PLIN3 M6PRBP1 TIP47O6066411
PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)PHF1 PCL1O4318911
Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1)LPIN1 KIAA0188Q1469311
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma)PIP5K1C KIAA0589O6033111
Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)PAIP2 PAIP2A HSPC218Q9BPZ311
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)DDX5 G17P1 HELR HLR1P1784411
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)CIAO1 WDR39O7607111
Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like)PREPL KIAA0436Q4J6C611
Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74)PTGR1 LTB4DHQ1491411
Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)PTOV1 ACID2 PP642 UNQ6127/PRO20092Q86YD111
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)ADRM1 GP110Q1618611
Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1)AATF CHE1 DED HSPC277Q9NY6111
Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5)BTG3 ANA TOB5Q1420111
Protein C-ets-1 (p54)ETS1 EWSR2P1492111
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)CASC3 MLN51O1523411
Protein CASPCUX1 CUTL1Q1394811
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