EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1)SMCHD1 KIAA0650A6NHR946
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)SMARCC2 BAF170Q8TAQ246
Transcription factor COE2 (Early B-cell factor 2) (EBF-2)EBF2 COE2Q9HAK246
Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1) (Tumor-associated antigen L6)TM4SF1 M3S1 TAAL6P3040846
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)PTPN12Q0520946
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)VPS45 VPS45A VPS45BQ9NRW746
182 kDa tankyrase-1-binding proteinTNKS1BP1 KIAA1741 TAB182Q9C0C245
7,8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55) (2-hydroxy-dATP diphosphatase) (EC 3.6.1.56) (8-oxo-dGTPase) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)NUDT1 MTH1P3663945
AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)AMPD2Q0143345
Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)ANXA13 ANX13P2721645
ATPase family AAA domain-containing protein 3AATAD3AQ9NVI745
CDC42 small effector protein 2 (Small effector of CDC42 protein 2)CDC42SE2 SPEC2Q9NRR345
CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)CISD2 CDGSH2 ERIS ZCD2Q8N5K145
Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE)CENPEQ0222445
Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)CSTF3Q1299645
Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment]C2P0668145
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)SLC7A11Q9UPY545
Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein)UQCRB UQBPP1492745
D-tyrosyl-tRNA(Tyr) deacylase 1 (EC 3.1.-.-) (DNA-unwinding element-binding protein B) (DUE-B) (Histidyl-tRNA synthase-related)DTD1 C20orf88 DUEB HARS2Q8TEA845
DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)TOP2BQ0288045
EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)EFEMP2 FBLN4 UNQ200/PRO226O9596745
Follistatin-related protein 1 (Follistatin-like protein 1)FSTL1 FRPQ1284145
General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)GTF2I BAP135 WBSCR6P7834745
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)GAPVD1 GAPEX5 KIAA1521 RAP6Q14C8645
H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)NHP2 NOLA2 HSPC286Q9NX2445
Heme oxygenase 2 (HO-2) (EC 1.14.14.18)HMOX2 HO2P3051945
Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain)HBG2P6989245
Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)HSPBP1 HSPBP PP1845Q9NZL445
Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1)HSDL2 C9orf99 SDR13C1Q6YN1645
Immunoglobulin heavy variable 3-48 (Ig heavy chain V-III region WEA)IGHV3-48P0176345
Matrix remodeling-associated protein 8 (Limitrin)MXRA8Q9BRK345
mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)RNMT KIAA0398O4314845
Mucin-5AC (MUC-5AC) (Gastric mucin) (Lewis B blood group antigen) (LeB) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM)MUC5AC MUC5P9808845
Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase)NRDC NRD1O4384745
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]NOTCH3Q9UM4745
Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)MTDH AEG1 LYRICQ86UE445
Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein)LZICQ8WZA045
Protein MON2 homolog (Protein SF21)MON2 KIAA1040 SF21Q7Z3U745
Putative helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)MOV10 KIAA1631Q9HCE145
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)ARHGAP17 RICH1 MSTP066 MSTP110Q68EM745
RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)RBM8A RBM8 HSPC114 MDS014Q9Y5S945
Signal peptidase complex subunit 3 (EC 3.4.-.-) (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)SPCS3 SPC22 UNQ1841/PRO3567P6100945
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)SART3 KIAA0156 TIP110Q1502045
Synembryn-A (Protein Ric-8A)RIC8AQ9NPQ845
THO complex subunit 2 (Tho2) (hTREX120)THOC2 CXorf3Q8NI2745
THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)THOC6 WDR58 PSEC0006Q86W4245
Transforming growth factor beta-2 (TGF-beta-2) (BSC-1 cell growth inhibitor) (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) (Polyergin) [Cleaved into: Latency-associated peptide (LAP)]TGFB2P6181245
Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma)EIF2B3Q9NR5045
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)VANGL1 STB2Q8TAA945
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)PLCG2P1688544
AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin)AP1M2Q9Y6Q544
Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)PEA15Q1512144
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39)BCAT1 BCT1 ECA39P5468744
Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP-18) (hCAP-18) [Cleaved into: Antibacterial peptide FALL-39 (FALL-39 peptide antibiotic); Antibacterial peptide LL-37]CAMP CAP18 FALL39 HSD26P4991344
Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9)CNBP RNF163 ZNF9P6263344
Choline transporter-like protein 4 (Solute carrier family 44 member 4)SLC44A4 C6orf29 CTL4 NG22 UNQ441/PRO874Q53GD344
Disco-interacting protein 2 homolog C (DIP2 homolog C)DIP2C KIAA0934Q9Y2E444
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)POLR2C A-152E5.7P1938744
Double-stranded RNA-binding protein Staufen homolog 1STAU1 STAUO9579344
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)RNF20 BRE1AQ5VTR244
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)EPS15 AF1PP4256644
Gem-associated protein 5 (Gemin5)GEMIN5Q8TEQ644
Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Glutathione transferase T1-1)GSTT1P3071144
Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35)GET4 C7orf20 CEE TRC35 CGI-20Q7L5D644
Immunoglobulin lambda variable 3-19 (Ig lambda chain V-III region SH)IGLV3-19P0171444
Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11)IPO11 RANBP11Q9UI2644
Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)ICAM3P3294244
Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)KRT72 K6IRS2 KB35 KRT6 KRT6IRS2Q14CN444
La-related protein 1 (La ribonucleoprotein domain family member 1)LARP1 KIAA0731 LARPQ6PKG044
Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)LSS OSCP4844944
Lipocalin-1 (Tear lipocalin) (Tlc) (Tear prealbumin) (TP) (Von Ebner gland protein) (VEG protein)LCN1 VEGPP3102544
Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)LPPQ9305244
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)LRP2P9816444
MAGUK p55 subfamily member 5MPP5Q8N3R944
Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen)MAGED2 BCG1Q9UNF144
Myb-binding protein 1AMYBBP1A P160Q9BQG044
NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)UBA3 UBE1CQ8TBC444
Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase)LCATP0418044
Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]KLKB1 KLK3P0395244
Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c)GP1BBP1322444
POTE ankyrin domain family member IPOTEIP0CG3844
POTE ankyrin domain family member JPOTEJP0CG3944
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)PRPF6 C20orf14O9490644
Proteasome subunit alpha type-7-like (EC 3.4.25.1)PSMA8 PSMA7LQ8TAA344
Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4)PIPSL PSMD4P2A2A3N644
Ras-related protein Rab-6C (Rab6-like protein WTH3)RAB6C WTH3Q9H0N044
Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)RFC3P4093844
Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)ARHGEF18 KIAA0521Q6ZSZ544
Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)SFRP1 FRP FRP1 SARP2Q8N47444
Sn1-specific diacylglycerol lipase beta (DGL-beta) (EC 3.1.1.-) (KCCR13L)DAGLBQ8NCG744
Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)SLC52A2 GPR172A PAR1 RFT3Q9HAB344
Tenascin-X (TN-X) (Hexabrachion-like protein)TNXB HXBL TNX TNXB1 TNXB2 XBP2210544
Thymidine kinase, cytosolic (EC 2.7.1.21)TK1P0418344
Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)TFPI LACI TFPI1P1064644
Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B)TOR1AIP1 LAP1Q5JTV844
Trans-Golgi network integral membrane protein 2 (TGN38 homolog) (TGN46) (TGN48) (Trans-Golgi network protein TGN51)TGOLN2 TGN46 TGN51O4349344
Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)TAGLN SM22 WS3-10Q0199544
Transmembrane protein 165 (Transmembrane protein PT27) (Transmembrane protein TPARL)TMEM165 TPARLQ9HC0744
U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)PRPF4 PRP4O4317244
U6 snRNA-associated Sm-like protein LSm8LSM8O9577744
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