EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Immunoglobulin heavy constant alpha 2 (Ig alpha-2 chain C region) (Ig alpha-2 chain C region BUT) (Ig alpha-2 chain C region LAN)IGHA2P0187777
Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha)LAMA3 LAMNAQ1678777
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]NOTCH2Q0472177
Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase)FKBP3 FKBP25Q0068877
Polypeptide N-acetylgalactosaminyltransferase 2 (EC (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]GALNT2Q1047177
Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)S100A7 PSOR1 S100A7CP3115177
Protein-glutamine gamma-glutamyltransferase E (EC (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]TGM3Q0818877
Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)SLC39A10 KIAA1265 ZIP10Q9ULF577
ADP-ribosylation factor-like protein 1ARL1P4061676
Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL)API5 MIG8Q9BZZ576
Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH)CAPN7 PALBHQ9Y6W376
Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201)PROCR EPCRQ9UNN876
Endothelin-converting enzyme 1 (ECE-1) (EC
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)FEN1 RAD2P3974876
Hemicentin-1 (Fibulin-6) (FIBL-6)HMCN1 FIBL6Q96RW776
Histone H2B type 1-B (Histone H2B.1) (Histone H2B.f) (H2B/f)HIST1H2BB H2BFFP3377876
HLA class I histocompatibility antigen, A-69 alpha chain (Aw-69) (HLA class I histocompatibility antigen, A-28 alpha chain) (MHC class I antigen A*69)HLA-A HLAAP1031676
Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225)IFITM1 CD225 IFI17P1316476
Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)LAMA4Q1636376
Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)P4HA1 P4HAP1367476
Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1)MEMO1 C2orf4 MEMO NS5ATP7 CGI-27Q9Y31676
Ras-related protein Rab-6BRAB6BQ9NRW176
Ribose-phosphate pyrophosphokinase 2 (EC (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)PRPS2P1190876
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC (Flavoprotein subunit of complex II) (Fp)SDHA SDH2 SDHFP3104076
Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268Q9H3N176
UDP-glucose 4-epimerase (EC (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC (UDP-galactose 4-epimerase)GALEQ1437676
Very-long-chain 3-oxoacyl-CoA reductase (EC (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC (Short chain dehydrogenase/reductase family 12C member 1)HSD17B12 SDR12C1Q53GQ076
Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI)ANP32A C15orf1 LANP MAPM PHAP1P3968775
CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha)CD5L API6 UNQ203/PRO229O4386675
Costars family protein ABRACL (ABRA C-terminal-like protein)ABRACL C6orf115 HSPC280 PRO2013Q9P1F375
DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)RAD50Q9287875
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)KHDRBS1 SAM68Q0766675
Oxysterol-binding protein 1OSBP OSBP1P2205975
Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)PECAM1P1628475
Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer)PCOLCE PCPE1Q1511375
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]PTMA TMSAP0645475
Putative histone H2B type 2-C (Histone H2B.t) (H2B/t)HIST2H2BCQ6DN0375
Serine/threonine-protein kinase mTOR (EC (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1P4234575
Signal transducing adapter molecule 1 (STAM-1)STAM STAM1Q9278375
Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)SNX9 SH3PX1 SH3PXD3AQ9Y5X175
Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)SLC26A2 DTD DTDSTP5044375
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)TJP2 X104 ZO2Q9UDY275
Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1)UBL3 PNSC1O9516475
UDP-glucuronic acid decarboxylase 1 (EC (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1)UXS1 UNQ2538/PRO6079Q8NBZ775
3'(2'),5'-bisphosphate nucleotidase 1 (EC (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)BPNT1O9586174
Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)ARPC1A SOP2LQ9274774
Alpha-adducin (Erythrocyte adducin subunit alpha)ADD1 ADDAP3561174
Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)C1QTNF3 CTRP3 UNQ753/PRO1484Q9BXJ474
Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB)DNASE1L1 DNAS1L1 DNL1LP4918474
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)EIF1AX EIF1A EIF4CP4781374
Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)EXOSC4 RRP41 SKI6Q9NPD374
FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)FARP1 CDEP PLEKHC2Q9Y4F174
Galectin-7 (Gal-7) (HKL-14) (PI7) (p53-induced gene 1 protein)LGALS7 PIG1; LGALS7BP4792974
Histone H1.3 (Histone H1c) (Histone H1s-2)HIST1H1D H1F3P1640274
HLA class I histocompatibility antigen, B-59 alpha chain (MHC class I antigen B*59)HLA-B HLABQ2994074
Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)KRT4 CYK4P1901374
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)TOMM70 KIAA0719 TOM70 TOMM70AO9482674
Phospholipase D3 (PLD 3) (EC (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3)PLD3Q8IV0874
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx) (EC (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)GPX4P3696974
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)PRPSAP1Q1455874
Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1)TMBIM1 LFG3 RECS1 PP1201 PSEC0158Q969X174
Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]RBP4 PRO2222P0275374
Ribonuclease UK114 (EC 3.1.-.-) (14.5 kDa translational inhibitor protein) (p14.5) (Heat-responsive protein 12) (UK114 antigen homolog)HRSP12 PSPP5275874
Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)SCAMP4Q969E274
Serine/threonine-protein kinase 10 (EC (Lymphocyte-oriented kinase)STK10 LOKO9480474
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)SMC4 CAPC SMC4L1Q9NTJ374
Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8)TSPAN3 TM4SF8O6063774
Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]TGFB1 TGFBP0113774
Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)SSR1 TRAPA PSEC0262P4330774
45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4)SDF4 CAB45 PSEC0034Q9BRK573
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)ARL6IP1 ARL6IP ARMER KIAA0069Q1504173
Crk-like proteinCRKLP4610973
Cytosolic purine 5'-nucleotidase (EC (Cytosolic 5'-nucleotidase II)NT5C2 NT5B NT5CP PNT5P4990273
DNA replication licensing factor MCM5 (EC (CDC46 homolog) (P1-CDC46)MCM5 CDC46P3399273
G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2)GPRC5B RAIG2Q9NZH073
GTP-binding protein SAR1b (GTP-binding protein B) (GTBPB)SAR1B SARA2 SARBQ9Y6B673
Guanine nucleotide-binding protein G(o) subunit alphaGNAO1P0947173
Histone H2B type 1-L (Histone H2B.c) (H2B/c)HIST1H2BL H2BFCQ9988073
HLA class I histocompatibility antigen, A-3 alpha chain (MHC class I antigen A*3)HLA-A HLAAP0443973
Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)KPNA3 QIP2O0050573
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.-) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog)AASDHPPT CGI-80 HAH-P HSPC223 x0005Q9NRN773
Phosphoglucomutase-2 (PGM 2) (EC (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphopentomutase) (EC MSTP006Q96G0373
Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA)RABGAP1 HSPC094Q9Y3P973
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]RPA1 REPA1 RPA70P2769473
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]SAE1 AOS1 SUA1 UBLE1AQ9UBE073
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC (Tau-protein kinase PRKAA1) (EC AMPK1Q1313172
Alpha-mannosidase 2 (EC (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)MAN2A1 MANA2Q1670672
COMM domain-containing protein 9COMMD9 HSPC166Q9P00072
Complement component C6C6P1367172
DNA replication licensing factor MCM4 (EC (CDC21 homolog) (P1-CDC21)MCM4 CDC21P3399172
Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)EML4 C2orf2 EMAPL4Q9HC3572
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924O9490572
Fragile X mental retardation syndrome-related protein 1 (hFXR1p)FXR1P5111472
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)GCLM GLCLRP4850772
Hepatocyte growth factor receptor (HGF receptor) (EC (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)METP0858172
Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0)HNRNPA0 HNRPA0Q1315172
HLA class I histocompatibility antigen, B-8 alpha chain (MHC class I antigen B*8)HLA-B HLABP3046072
Long-chain-fatty-acid--CoA ligase 3 (EC (Long-chain acyl-CoA synthetase 3) (LACS 3)ACSL3 ACS3 FACL3 LACS3O9557372
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