EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen)Col7a1Q638707
Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (mCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog)Ncapd2 Capd2 Cnap1 Kiaa0159Q8K2Z47
Cordon-bleu protein-like 1 (Cobl-related protein 1)Cobll1 Coblr1 Kiaa0977Q3UMF07
CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (CTPsH) (UTP--ammonia ligase 2)Ctps2P703037
CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (mETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (mNapor) (RNA-binding protein BRUNOL-3)Celf2 Cugbp2 NaporQ9Z0H47
Cullin-4A (CUL-4A)Cul4aQ3TCH77
Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]Uqcrfs1Q9CR687
Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)Cox6cQ9CPQ17
Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (CLM1) (SEC7 homolog A) (mSec7-1)Cyth1 Pscd1Q9QX117
Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related factor 4)Crlf3 Creme9 Cytor4Q9Z2L77
Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1)Nck1Q99M517
Dedicator of cytokinesis protein 2 (Protein Hch)Dock2Q8C3J57
Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-)Dhrs1 D14ertd484eQ99L047
Density-regulated protein (DRP)DenrQ9CQJ67
DesminDesP310017
Disheveled-associated activator of morphogenesis 2Daam2 Kiaa0381Q80U197
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog)Polr2eQ80UW87
Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (T-DSP11) (Vaccinia H1-related phosphatase) (VHR)Dusp3Q9D7X37
Dynein light chain roadblock-type 1 (Dynein light chain 2A, cytoplasmic)Dynlrb1 Dncl2a Dnlc2aP626277
Dynein light chain Tctex-type 1 (Activator of G-protein signaling 2) (AGS2) (T-complex testis-specific protein 1) (TCTEX-1)Dynlt1 Tctel1 Tctex-1 Tctex1P518077
Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2)Dst Bpag1 Macf2Q91ZU67
E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1)Mib1 Dip1 Kiaa1323 MibQ80SY47
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)Rnf114 Zfp228 Zfp313 Znf228 Znf313Q9ET267
E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (Goliath-related E3 ubiquitin-protein ligase 4) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)Rnf149 Greul4Q3U2C57
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)Trim25 Efp Zfp147 Znf147Q615107
Elongator complex protein 2 (ELP2) (STAT3-interacting protein 1) (StIP1)Elp2 Statip1Q91WG47
EMILIN-2 (Basilin) (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2)Emilin2Q8K4827
Endophilin-B1 (SH3 domain-containing GRB2-like protein B1)Sh3glb1 Kiaa0491Q9JK487
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32)Ergic1 Ergic32Q9DC167
Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH)Echs1Q8BH957
Eph receptor A3 (Ephrin type-A receptor 3) (Putative uncharacterized protein)Epha3Q8BRB17
Ephrin type-B receptor 1 (EC 2.7.10.1)Ephb1Q8CBF37
Ephrin type-B receptor 2 (EC 2.7.10.1) (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3)Ephb2 Epth3 Nuk Sek3P547637
Epithelial cell adhesion molecule (Ep-CAM) (Epithelial glycoprotein 314) (EGP314) (mEGP314) (Protein 289A) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)Epcam Tacstd1Q99JW57
Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2)Epn2Q8CHU37
ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)Emc2 Kiaa0103 Ttc35Q9CRD27
Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2)Eif5a2Q8BGY27
Excitatory amino acid transporter 1 (Glial high affinity glutamate transporter) (High-affinity neuronal glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3)Slc1a3 Eaat1 Gmt1P565647
Exocyst complex component 5 (Exocyst complex component Sec10)Exoc5 Sec10l1Q3TPX47
Exocyst complex component 8 (Exocyst complex 84 kDa subunit)Exoc8Q6PGF77
Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog)Exosc6 Mtr3Q8BTW37
Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1 homolog)Ext1P974647
Exportin-T (Exportin(tRNA)) (tRNA exportin)XpotQ9CRT87
Extended synaptotagmin-2 (E-Syt2)Esyt2 D12Ertd551e Fam62bQ3TZZ77
Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1)Sod3O091647
F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)Fbxl20 Fbl2Q9CZV87
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1)Fen1 FEN1 mCG_1942Q91Z507
Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)BlvrbQ923D27
Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase)FahP355057
G protein-coupled receptor, family C, group 5, member A (Retinoic acid-induced protein 3)Gprc5a mCG_22262G5E8C37
Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactocerebroside beta-galactosidase) (Galactosylceramidase) (Galactosylceramide beta-galactosidase)GalcP548187
Gamma-adducin (Adducin-like protein 70)Add3 AddlQ9QYB57
Gamma-tubulin complex component 2 (GCP-2)Tubgcp2 Gcp2Q921G87
Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3)Gm2aQ606487
Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)Gpx3P464127
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)Gapdhs Gapd-s GapdsQ644677
Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP)PgpQ8CHP87
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)Gsk3aQ2NL517
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)Gapvd1 Gapex5 Kiaa1521Q6PAR57
Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH)GdaQ9R1117
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)Gnai1 Gnai-1B2RSH27
Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin)Gnl3 NsQ8CI117
H-2 class I histocompatibility antigen, D-37 alpha chainH2-T23P063397
H-2 class I histocompatibility antigen, Q7 alpha chain (QA-2 antigen)H2-Q7P144297
H-2 class I histocompatibility antigen, Q8 alpha chainH2-Q8P144307
H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)Gar1 Nola1Q9CY667
HEAT repeat-containing protein 5AHeatr5a Kiaa1316Q5PRF07
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)Hspa4l Apg1 Hsp4l Osp94P487227
Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2-OST) (2OST) (EC 2.8.2.-)Hs2st1 Hs2stQ8R3H77
Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (Serpin D1)Serpind1 Hcf2 HciiP491827
Hepatocyte growth factor-regulated tyrosine kinase substrateHgs HrsQ99LI87
Hepatoma-derived growth factor (HDGF)Hdgf Tdrm1P518597
Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (JKT41-binding protein)Hnrnpdl Hnrpdl JktbpQ9Z1307
Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) (HK I) (Hexokinase, tumor isozyme)Hk1P177107
Histone H1t (Testicular H1 histone)Hist1h1t H1ft H1tQ071337
Histone H2AHist1h2alF8WIX87
Histone H2B type 2-E (H2b 613)Hist2h2beQ645247
Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)Carm1 Prmt4Q9WVG67
Hormone-sensitive lipase (HSL) (EC 3.1.1.79)LipeP543107
Ig gamma-2B chain C regionIgh-3P018677
Ig gamma-3 chain C region0P039877
Ig heavy chain V region 4410P018067
Ig kappa chain V-II region 26-100P016317
Immunoglobulin-binding protein 1 (Alpha4 phosphoprotein) (CD79a-binding protein 1) (Lymphocyte signal transduction molecule alpha 4) (Protein phosphatase 2/4/6 regulatory subunit) (p52)Igbp1 Pc52Q612497
Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)Ipo8Q7TMY77
Importin-9 (Imp9) (Importin-9a) (Imp9a) (Importin-9b) (Imp9b) (Ran-binding protein 9) (RanBP9)Ipo9 Imp9 Ranbp9Q91YE67
Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)Ints3Q7TPD07
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)Itga2Q624697
Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen 15) (Ly-15) (CD antigen CD11a)Itgal Lfa-1 Ly-15P240637
IQ motif-containing GTPase-activating protein 3Iqgap3F8VQ297
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)Idh3gP704047
Isocitrate dehydrogenase [NAD] subunit, mitochondrial (EC 1.1.1.41)Idh3b mCG_9915Q91VA77
Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)IvdQ9JHI57
Keratin 90Krt90 4732456N10RikE9Q1Z07
Keratin, type I cytoskeletal 18 (Cytokeratin endo B) (Keratin D) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)Krt18 Kerd Krt1-18P057847
Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Cytoskeletal 57 kDa keratin) (Keratin-4) (K4) (Type-II keratin Kb4)Krt4 Krt2-4P077447
Kinase D-interacting substrate 220Kidins220E9Q9B77
Kinesin-like protein KIF20A (Kinesin-like protein 174) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)Kif20a Rab6kiflP973297
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog)Krit1 Ccm1Q6S5J67
Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)Cyp51a1 Cyp51Q8K0C47
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