EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Nascent polypeptide-associated complex subunit alpha (Alpha-NAC) (Alpha-NAC/1.9.2)NacaQ6081713
Neuronal membrane glycoprotein M6-a (M6a)Gpm6a M6aP3580213
NHP2-like protein 1 (Fertilization antigen 1) (FA-1) (High mobility group-like nuclear protein 2 homolog 1) (Sperm-specific antigen 1) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]Snu13 Nhp2l1 Ssfa1Q9D0T113
Nidogen-2 (NID-2) (Entactin-2)Nid2O8832213
Nuclear migration protein nudC (Nuclear distribution protein C homolog) (Silica-induced gene 92 protein) (SIG-92)NudcO3568513
Palmitoyltransferase ZDHHC5 (EC (Zinc finger DHHC domain-containing protein 5) (DHHC-5)Zdhhc5 Kiaa1748Q8VDZ413
Peripheral plasma membrane protein CASK (EC (Calcium/calmodulin-dependent serine protein kinase)CaskO7058913
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MPF-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC (EC (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]Hsd17b4 Edh17b4P5166013
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC
Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase)Pfas Kiaa0361Q5SUR013
Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)Plekhb2 Evt2Q9QZC713
Protein FAM98BFam98bQ80VD113
Protein transport protein Sec23A (SEC23-related protein A)Sec23a Sec23 Sec23rQ0140513
Protein VAC14 homologVac14 D8Wsu151eQ80WQ213
Protein-glutamine gamma-glutamyltransferase 2 (EC (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase-2) (TGase-2)Tgm2P2198113
Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC (Pyrroline-5-carboxylate reductase-like protein)PycrlQ9DCC413
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC
Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18)Lamtor1Q9CQ2213
Ras-related protein Rab-12 (Rab-13)Rab12P3528313
RNA-binding protein 3 (RNA-binding motif protein 3)Rbm3O8908613
RNA-binding protein 39 (Coactivator of activating protein 1 and estrogen receptors) (Coactivator of AP-1 and ERs) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Transcription coactivator CAPER)Rbm39 Caper Rnpc2Q8VH5113
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)Skp1 Skp1aQ9WTX513
Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2)Scamp2Q9ERN013
Serine protease inhibitor A3K (Serpin A3K) (Contrapsin) (SPI-2)Serpina3k Mcm2 Spi2P0775913
Serine/threonine-protein kinase TAO3 (EC (Thousand and one amino acid protein 3)Taok3Q8BYC613
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT)Sgta SgtQ8BJU013
Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)SnrpgP6230913
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (mKCC1)Slc12a4 Kcc1Q9JIS813
Sulfhydryl oxidase 1 (mSOx) (EC (Quiescin Q6) (Skin sulfhydryl oxidase)Qsox1 Qscn6 SoxQ8BND513
Synaptobrevin homolog YKT6 (EC 2.3.1.-)Ykt6Q9CQW113
Syntaxin-7Stx7 Syn7O7043913
Syntaxin-8 (Syntaxin-like protein 3I35)Stx8O8898313
Target of Myb protein 1Tom1O8874613
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)Tjp2 Zo2Q9Z0U113
Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII)Tcn2O8896813
Transmembrane 9 superfamily member 2Tm9sf2P5802113
Tripartite motif-containing protein 47Trim47Q8C0E313
Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)Tmod3Q9JHJ013
Tyrosine--tRNA ligase, cytoplasmic (EC (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]YarsQ91WQ313
Tyrosine-protein kinase CSK (EC (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK)CskP4124113
UDP-glucuronic acid decarboxylase 1 (EC (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1)Uxs1Q91XL313
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)Myo18a MyspdzQ9JMH913
UV excision repair protein RAD23 homolog B (HR23B) (mHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)Rad23b Mhr23bP5472813
V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)Atp6v1f Atp6s14 VatfQ9D1K213
Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22)Snf8 D11Moh34Q9CZ2813
Very-long-chain 3-oxoacyl-CoA reductase (EC (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC (KIK-I)Hsd17b12 Kik1O7050313
Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)HdlbpQ8VDJ313
Vitronectin (VN) (S-protein) (Serum-spreading factor)VtnP2978813
von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog)Vwa5a Loh11cr2aQ99KC813
WD repeat-containing protein 48 (USP1-associated factor 1)Wdr48 Kiaa1449 Uaf1Q8BH5713
WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) [Cleaved into: WD repeat-containing protein 61, N-terminally processed]Wdr61Q9ERF313
Y+L amino acid transporter 2 (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)Slc7a6 Kiaa0245Q8BGK613
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Y-box protein 3)Ybx3 Csda Msy4Q9JKB313
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)Plcb3P5143212
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)Plcd3 Kiaa1964Q8K2J012
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-gamma-2) (PLC-gamma-2)Plcg2Q8CIH512
40S ribosomal protein S12Rps12P6332312
5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)Prkag1 PrkaacO5495012
Acetyl-CoA acetyltransferase, cytosolic (EC (Cytosolic acetoacetyl-CoA thiolase)Acat2Q8CAY612
Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (LANP) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A)Anp32a Anp32 LanpO3538112
Actin, gamma-enteric smooth muscle (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin)Actg2 Acta3 ActsgP6326812
Adenosine kinase (AK) (EC (Adenosine 5'-phosphotransferase)AdkP5526412
ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2)Arl8a Arl10b Gie2Q8VEH312
Afadin (Afadin adherens junction formation factor) (Protein Af-6)Afdn Af6 Mllt4Q9QZQ112
Aldehyde dehydrogenase family 3 member B1 (EC (Aldehyde dehydrogenase 7)Aldh3b1 Aldh7Q80VQ012
Aldose reductase-related protein 2 (AR) (EC (Aldehyde reductase) (Fibroblast growth factor-regulated protein) (Protein FR-1)Akr1b8 FgfrpP4537712
Alpha globin 1 (Alpha globin 2) (Alpha-globin) (Globin c1) (Hemoglobin alpha, adult chain 1) (Hemoglobin alpha, adult chain 2) (Putative uncharacterized protein)Hba-a2 Glnc1 haemaglobin alpha 1 haemaglobin alpha 2 Hba-a1Q91VB812
ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase subunit b) (ATPase subunit b)Atp5f1Q9CQQ712
ATP synthase subunit O, mitochondrial (Oligomycin sensitivity conferral protein) (OSCP)Atp5o D12Wsu28eQ9DB2012
ATP-binding cassette sub-family F member 2Abcf2Q99LE612
ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein 1 homolog) (Urate exporter) (CD antigen CD338)Abcg2 Abcp Bcrp1Q7TMS512
ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)Pfkm Pfk-m PfkaP4785712
ATP-dependent RNA helicase DDX19A (EC (DEAD box RNA helicase DEAD5) (mDEAD5) (DEAD box protein 19A) (Eukaryotic translation initiation factor 4A-related sequence 1)Ddx19a Ddx19 Eif4a-rs1Q6165512
Biglycan (Bone/cartilage proteoglycan I) (PG-S1)BgnP2865312
Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3)Capn5 Ncl3O0868812
Carboxypeptidase D (EC (Metallocarboxypeptidase D) (gp180)CpdO8900112
CD97 antigen (CD antigen CD97) [Cleaved into: CD97 antigen subunit alpha; CD97 antigen subunit beta]Cd97Q9Z0M612
Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a)Chmp1a Chmp1 Pcoln3Q921W012
Clathrin light chain B (Lcb)CltbQ6IRU512
Claudin domain-containing protein 1 (Claudin-25)Cldnd1 Cldn25 D11Moh34Q9CQX512
Cleavage and polyadenylation specificity factor subunit 5 (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21)Nudt21 Cpsf5Q9CQF312
Collagen alpha-1(IV) chain [Cleaved into: Arresten]Col4a1P0246312
Collagen alpha-1(V) chainCol5a1O8820712
Complement C1q subcomponent subunit AC1qaP9808612
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6)Cops6 Csn6O8854512
Copine-8 (Copine VIII)Cpne8Q9DC5312
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)H2afy2 H2afy3Q8CCK012
Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1)Csrp1 Crp1 CsrpP9731512
Cystine/glutamate transporter (Amino acid transport system xc-) (Solute carrier family 7 member 11) (xCT)Slc7a11Q9WTR612
Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC (Aldehyde dehydrogenase family 1 member L1)Aldh1l1 FthfdQ8R0Y612
Cytosolic purine 5'-nucleotidase (EC (Cytosolic 5'-nucleotidase II)Nt5c2Q3V1L412
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)Dock11 Ziz2A2AF4712
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Interferon-gamma-inducible protein Mg11) (SAM domain and HD domain-containing protein 1)Samhd1 Mg11Q6071012
Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein 1) (ULIP-1)Dpysl3 Drp3 UlipQ6218812
Disco-interacting protein 2 homolog A (DIP2 homolog A)Dip2a Dip2 Kiaa0184Q8BWT512
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC (MAPK/ERK kinase 3) (MEK 3)Map2k3 Mkk3 Prkmk3O0911012
eIF-2-alpha kinase activator GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1)Gcn1 Gcn1l1E9PVA812
Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein)Ikbkap Elp1 IkapQ7TT3712
Elongator complex protein 3 (EC
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