EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)AIP XAP2O0017048
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]PAPSS2 ATPSK2O9534048
Calcium load-activated calcium channel (CLAC channel) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3)TMCO1 TMCC4 PNAS-10 PNAS-136 UNQ151/PRO177Q9UM0048
CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99)CD99L2 MIC2L1 UNQ1964/PRO4486Q8TCZ248
Dolichol-phosphate mannosyltransferase subunit 1 (EC (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1)DPM1O6076248
Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17)FGFBP1 FGFBP HBP17Q1451248
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)FHL2 DRAL SLIM3Q1419248
Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)TUBGCP2 GCP2Q9BSJ248
Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)HDGF HMG1L2P5185848
HLA class I histocompatibility antigen, A-23 alpha chain (HLA class I histocompatibility antigen, A-9 alpha chain) (MHC class I antigen A*23)HLA-A HLAAP3044748
Hyccin (Down-regulated by CTNNB1 protein A) (Protein FAM126A)FAM126A DRCTNNB1AQ9BYI348
Kelch-like protein 17 (Actinfilin)KLHL17Q6TDP448
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)SPINT2 HAI2 KOPO4329148
Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen)MAGEE1 HCA1 KIAA1587Q9HCI548
Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)NXF1 TAPQ9UBU948
Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1)ATP13A3 AFURS1Q9H7F048
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)PCSK9 NARC1 PSEC0052Q8NBP748
Protein kinase C delta type (EC (Tyrosine-protein kinase PRKCD) (EC (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]PRKCDQ0565548
Protein VAC14 homolog (Tax1-binding protein 2)VAC14 TAX1BP2 TRXQ08AM648
Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1)REEP6 C19orf32 DP1L1Q96HR948
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)SH3KBP1 CIN85Q96B9748
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)SORL1 C11orf32Q9267348
TOM1-like protein 2 (Target of Myb-like protein 2)TOM1L2Q6ZVM748
Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)SSR3 TRAPGQ9UNL248
U8 snoRNA-decapping enzyme (EC (IDP phosphatase) (IDPase) (EC (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (U8 snoRNA-binding protein H29K) (m7GpppN-mRNA hydrolase)NUDT16Q96DE048
Vesicle transport protein GOT1B (Germ cell tumor 2) (Golgi transport 1 homolog B) (Putative NF-kappa-B-activating protein 470) (hGOT1a)GOLT1B GCT2 GOT1A CGI-141 HDCMA39P UNQ432/PRO793Q9Y3E048
Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)VTI1B VTI1 VTI1L VTI1L1 VTI2Q9UEU048
Zymogen granule protein 16 homolog BZG16B UNQ773/PRO1567Q96DA048
39S ribosomal protein L12, mitochondrial (L12mt) (MRP-L12) (5c5-2) (Mitochondrial large ribosomal subunit protein bL12m)MRPL12 MRPL7 RPML12P5281547
Alcohol dehydrogenase 6 (EC
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)MGAT1 GGNT1 GLCT1 GLYT1 MGATP2657247
Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N)EPB41L1 KIAA0338Q9H4G047
Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)B4GALT5O4328647
Carboxypeptidase N catalytic chain (CPN) (EC (Anaphylatoxin inactivator) (Arginine carboxypeptidase) (Carboxypeptidase N polypeptide 1) (Carboxypeptidase N small subunit) (Kininase-1) (Lysine carboxypeptidase) (Plasma carboxypeptidase B) (Serum carboxypeptidase N) (SCPN)CPN1 ACBPP1516947
Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5)COMPP4974747
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1Q9BY6747
DNA-directed RNA polymerase II subunit RPB2 (EC (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)POLR2BP3087647
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)DNAJB4 DNAJW HLJ1Q9UDY447
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)DIS3 KIAA1008 RRP44Q9Y2L147
Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)FMNL3 FHOD3 FRL2 KIAA2014 WBP3Q8IVF747
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC (mtGPD)GPD2P4330447
GTP:AMP phosphotransferase AK3, mitochondrial (EC (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)AK3 AK3L1 AK6 AKL3LQ9UIJ747
Guanidinoacetate N-methyltransferase (EC
Histone H1xH1FXQ9252247
Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r)HIST1H2BJ H2BFRP0689947
Inositol-3-phosphate synthase 1 (IPS 1) (EC (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1)ISYNA1 INO1Q9NPH247
LanC-like protein 2 (Testis-specific adriamycin sensitivity protein)LANCL2 GPR69B TASPQ9NS8647
Lipoma HMGIC fusion partner-like 2 proteinLHFPL2 KIAA0206Q6ZUX747
Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)CNNM3 ACDP3Q8NE0147
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)MTCH2 MIMP HSPC032Q9Y6C947
Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1)NCKAP1L HEM1P5516047
Neogenin (Immunoglobulin superfamily DCC subclass member 2)NEO1 IGDCC2 NGNQ9285947
Neutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]DEFA1 DEF1 DEFA2 MRS; DEFA1BP5966547
NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66)NUDCD1 CML66Q96RS647
Oligosaccharyltransferase complex subunit OSTC (Hydrophobic protein HSF-28)OSTC DC2 HDCMD45P HSPC307Q9NRP047
Pirin (EC (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)PIRO0062547
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225O7540047
Protein kinase C beta type (PKC-B) (PKC-beta) (EC PKCB PRKCB1P0577147
Protein O-GlcNAcase (OGA) (EC (Beta-N-acetylglucosaminidase) (EC 3.2.1.-) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)MGEA5 HEXC KIAA0679 MEA5O6050247
Serine/threonine-protein kinase MRCK alpha (EC (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)CDC42BPA KIAA0451Q5VT2547
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)PPP2R1BP3015447
Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)ATP1A3P1363747
Sorting nexin-27SNX27 KIAA0488 My014Q96L9247
TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)TBC1D10A EPI64 TBC1D10Q9BXI647
Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)SLC25A1 SLC20A3P5300747
Tsukushin (Tsukushi) (E2-induced gene 4 protein) (Leucine-rich repeat-containing protein 54)TSKU E2IG4 LRRC54 TSK UNQ850/PRO1788Q8WUA847
WW domain-binding protein 2 (WBP-2)WBP2Q969T947
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule)AQP1 CHIP28P2997246
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC (ManAc kinase)]GNE GLCNEQ9Y22346
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)CPSF1 CPSF160Q1057046
Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150)IKBKAP ELP1 IKAPO9516346
Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide]FBN2P3555646
Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)FHL1 SLIM1Q1364246
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)GABARAPL2 FLC3A GEF2P6052046
Glutathione S-transferase A1 (EC (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed]GSTA1P0826346
HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G)HLA-G HLA-6.0 HLAGP1769346
HLA class I histocompatibility antigen, B-53 alpha chain (Bw-53) (MHC class I antigen B*53)HLA-B HLABP3049146
Hydroxyacylglutathione hydrolase, mitochondrial (EC (Glyoxalase II) (Glx II)HAGH GLO2 HAGH1Q1677546
Immunoglobulin kappa variable 1-5 (Ig kappa chain V-I region CAR) (Ig kappa chain V-I region EU) (Ig kappa chain V-I region HK102) (Ig kappa chain V-I region Kue)IGKV1-5P0160246
InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions)PATJ INADLQ8NI3546
Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)ITGAL CD11AP2070146
Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-)IAH1Q2TAA246
Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein)LRRC1 LANOQ9BTT646
Matrix metalloproteinase-9 (MMP-9) (EC (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]MMP9 CLG4BP1478046
Nodal modulator 1 (pM5 protein)NOMO1 PM5Q1515546
Nucleoredoxin (EC NRXQ6DKJ446
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)PSIP1 DFS70 LEDGF PSIP2O7547546
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)PIK3R4 VPS15Q9957046
Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)ATP2B3Q1672046
Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36)CD36 GP3B GP4P1667146
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)PABPN1 PAB2 PABP2Q86U4246
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC; Cathepsin H heavy chain; Cathepsin H light chain]CTSH CPSBP0966846
Reelin (EC 3.4.21.-)RELNP7850946
Ribulose-phosphate 3-epimerase (EC (Ribulose-5-phosphate-3-epimerase)RPE HUSSY-17Q96AT946
Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5)PGAM5Q96HS146
Sialidase-1 (EC (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)NEU1 NANHQ9951946
STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase)STAMBP AMSHO9563046
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