EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)AP1M1 CLTNMQ9BXS587
AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)AP3S1 CLAPS3Q9257287
Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))]APOA2P0265287
C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)C4BPA C4BPP0400387
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]CDH1 CDHE UVOP1283087
Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)CAPN5 NCL3O1548487
Cysteine--tRNA ligase, cytoplasmic (EC (Cysteinyl-tRNA synthetase) (CysRS)CARSP4958987
Enhancer of rudimentary homologERHP8409087
Eukaryotic translation initiation factor 5B (eIF-5B) (EC (Translation initiation factor IF-2)EIF5B IF2 KIAA0741O6084187
Extracellular matrix protein 1 (Secretory component p85)ECM1Q1661087
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)RBBP7 RBAP46Q1657687
Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)NACAE9PAV387
Nucleolar protein 56 (Nucleolar protein 5A)NOP56 NOL5AO0056787
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41)PRPSAP2O6025687
Prefoldin subunit 3 (HIBBJ46) (Von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)VBP1 PFDN3P6175887
Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein)SBDS CGI-97Q9Y3A587
Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)SNRPG PBSCGP6230887
AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)AP1S1 AP19 CLAPS1P6196686
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)AP2S1 AP17 CLAPS2P5368086
Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24)CARHSP1Q9Y2V286
CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)CD99 MIC2 MIC2X MIC2YP1420986
Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)TMEM30A C6orf67 CDC50AQ9NV9686
Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)CEP55 C10orf3 URCC6Q53EZ486
Complement C1q subcomponent subunit CC1QC C1QGP0274786
Complement factor B (EC (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment]CFB BF BFDP0075186
CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318)CDCP1 TRASK UNQ2486/PRO5773Q9H5V886
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)CYFIP2 KIAA1168 PIR121Q96F0786
Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma)NAPG SNAPGQ9974786
Lysosomal alpha-glucosidase (EC (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]GAAP1025386
Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)RRBP1 KIAA1398Q9P2E986
Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC (EC (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]TKFC DAKQ3LXA386
Tyrosine-protein kinase CSK (EC (C-Src kinase) (Protein-tyrosine kinase CYL)CSKP4124086
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1P0862186
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)UBA6 MOP4 UBE1L2A0AVT186
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]PLAUP0074986
von Willebrand factor A domain-containing protein 1VWA1Q6PCB086
1,4-alpha-glucan-branching enzyme (EC (Brancher enzyme) (Glycogen-branching enzyme)GBE1Q0444685
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) (c-Myc-responsive protein RCL)DNPH1 C6orf108 RCLO4359885
Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein)CTNNA2 CAPRP2623285
Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1)CLDN3 C7orf1 CPETR2O1555185
Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)DYNLT1 TCTEL1 TCTEX-1 TCTEX1P6317285
Glutathione S-transferase kappa 1 (EC (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13)GSTK1 HDCMD47PQ9Y2Q385
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)ITGA4 CD49DP1361285
Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)KRT6C KRT6EP4866885
Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)FIS1 TTC11 CGI-135Q9Y3D685
N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100)NAA15 GA19 NARG1 NATH TBDN100Q9BXJ985
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]PSEN1 AD3 PS1 PSNL1P4976885
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)ADRM1 GP110Q1618685
Protein Shroom3 (Shroom-related protein) (hShrmL)SHROOM3 KIAA1481 SHRML MSTP013Q8TF7285
Rho-associated protein kinase 1 (EC (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)ROCK1Q1346485
V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)ATP6V1C1 ATP6C ATP6D VATCP2128385
Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)SMPDL3B ASML3BQ9248584
Aldehyde dehydrogenase, mitochondrial (EC (ALDH class 2) (ALDH-E2) (ALDHI)ALDH2 ALDMP0509184
ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein)ABCF1 ABC50Q8NE7184
Coagulation factor X (EC (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]F10P0074284
Cyclin-dependent-like kinase 5 (EC (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)CDK5 CDKN5Q0053584
Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)DSC1 CDHF1Q0855484
DNA replication licensing factor MCM7 (EC (CDC47 homolog) (P1.1-MCM3)MCM7 CDC47 MCM2P3399384
Interferon-induced, double-stranded RNA-activated protein kinase (EC (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC (p68 kinase)EIF2AK2 PKR PRKRP1952584
Isopentenyl-diphosphate Delta-isomerase 1 (EC (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1)IDI1Q1390784
Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)MVB12B C9orf28 FAM125BQ9H7P684
Prefoldin subunit 4 (Protein C-1)PFDN4 PFD4Q9NQP484
Protein transport protein Sec23B (SEC23-related protein B)SEC23BQ1543784
Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC (Pyrroline-5-carboxylate reductase-like protein)PYCRLQ53H9684
Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3)LAMTOR2 MAPBPIP ROBLD3 HSPC003Q9Y2Q584
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC PTPA PTPRL2P1843384
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform)PPP3CA CALNA CNAQ0820984
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)STXBP1 UNC18AP6176484
Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90)THY1P0421684
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)MYO18A CD245 KIAA0216 MYSPDZQ9261484
Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]ACE DCP DCP1P1282183
ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)ATP5C1 ATP5C ATP5CL1P3654283
Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]CLSTN1 CS1 KIAA0911O9498583
Copine-2 (Copine II)CPNE2Q96FN483
Cullin-4B (CUL-4B)CUL4B KIAA0695Q1362083
Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)UQCRC1P3193083
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)POLR2HP5243483
Glucosylceramidase (EC (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase)GBA GC GLUCP0406283
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)HIST1H2AB H2AFM; HIST1H2AE H2AFAP0490883
HLA class I histocompatibility antigen, A-1 alpha chain (MHC class I antigen A*1)HLA-A HLAAP3044383
HLA class I histocompatibility antigen, B-7 alpha chain (MHC class I antigen B*7)HLA-B HLABP0188983
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)IGSF3 EWI3 KIAA0466O7505483
LanC-like protein 1 (40 kDa erythrocyte membrane protein) (p40)LANCL1 GPR69AO4381383
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)BAG6 BAT3 G3P4637983
MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1)MPP6 VAM1Q9NZW583
Nicotinate phosphoribosyltransferase (NAPRTase) (EC (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1)NAPRT FHIP NAPRT1Q6XQN683
Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein)RFTN1 KIAA0084 MIG2Q1469983
Ras-related protein Rab-34 (Ras-related protein Rab-39) (Ras-related protein Rah)RAB34 RAB39 RAHQ9BZG183
Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23Q8WVM883
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]PPP6C PPP6O0074383
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1Q1468383
Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3)BTF3 NACB OK/SW-cl.8P2029083
2,4-dienoyl-CoA reductase, mitochondrial (EC (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)DECR1 DECR SDR18C1Q1669882
60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)TROVE2 RO60 SSA2P1015582
ADP-ribosylation factor-like protein 2ARL2P3640482
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)CRYAB CRYA2 HSPB5P0251182
AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)AP3D1 PRO0039O1461782
BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain)KCTD12 C13orf2 KIAA1778 PFET1Q96CX282
Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105Q1444482
Complement component C7C7P1064382
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