EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7)Macf1 Acf7 Aclp7 MacfQ9QXZ08
Mimecan (Osteoglycin)Ogn OgQ620008
Mitochondrial import inner membrane translocase subunit TIM50Timm50 Tim50Q9D8808
Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit)Tomm34Q9CYG78
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)Mapk14 Crk1 Csbp1 Csbp2P478118
Mitotic spindle assembly checkpoint protein MAD2A (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)Mad2l1 Mad2aQ9Z1B58
MOB kinase activator 1A (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B)Mob1a Mobk1b Mobkl1bQ921Y08
MOB-like protein phocein (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)Mob4 Mob3 Mobkl3 Phocn Prei3Q6PEB68
Myelin protein zero-like protein 1 (Protein zero-related)Mpzl1 PzrQ3TEW68
Myosin IF (Myosin-1F-like protein) (Unconventional myosin-If)Myo1f myosin-1F-like protein mCG_132700Q8CG298
N-terminal kinase-like protein (105 kDa kinase-like protein) (Mitosis-associated kinase-like protein NTKL) (SCY1-like protein 1)Scyl1Q9EQC58
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]Ntmt1 Mettl11aQ8R2U48
NAD(P)H-hydrate epimerase (EC (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase)Naxe Aibp Apoa1bpQ8K4Z38
Napsin-A (EC 3.4.23.-) (KDAP-1) (Kidney-derived aspartic protease-like protein) (KAP)Napsa Kdap NapO090438
NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)Uba3 Ube1cQ8C8788
Nuclear export mediator factor Nemf (Serologically defined colon cancer antigen 1 homolog)Nemf Sdccag1Q8CCP08
Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)Gtpbp4 Crfg Nog1Q99ME98
Olfactomedin-4 (OLM4)Olfm4Q3UZZ48
Olfactomedin-like protein 2B (Photomedin-2)Olfml2bQ3V1G48
Oxysterol-binding protein 1Osbp Kiaa4220Q3B7Z28
Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC (Rotamase H)PpihQ9D8688
Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein)Sacm1l Kiaa0851 Sac1Q9EP698
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)Prex1 Kiaa1415Q69ZK08
Phosphatidylinositol 4-kinase type 2-alpha (EC (Phosphatidylinositol 4-kinase type II-alpha)Pi4k2aQ2TBE68
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)Pip4k2b Pip5k2bQ80XI48
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)Pip4k2c Pip5k2cQ91XU38
Phosphoglucomutase-2 (PGM 2) (EC (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-1) (Phosphopentomutase) (EC Pgm1Q7TSV48
Phosphoinositide phospholipase C (EC
Phospholipid phosphatase 3 (EC (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b)Plpp3 Lpp3 Ppap2bQ99JY88
Phosphoserine phosphatase (PSP) (PSPase) (EC (O-phosphoserine phosphohydrolase)PsphQ99LS38
Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)Pttg1ipQ8R1438
Plasma kallikrein (EC (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]Klkb1 Klk3 PkP262628
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC
Plexin-B1Plxnb1 Kiaa0407Q8CJH38
Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)Ptbp1 PtbP172258
PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Addicsin) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (Prenylated Rab acceptor protein 2) (Protein JWa)Arl6ip5 Aip5 Jwa Pra2 Praf3Q8R5J98
Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)Vbp1 Pfdn3P617598
Probable ATP-dependent RNA helicase DDX47 (EC (DEAD box protein 47)Ddx47Q9CWX98
Probable palmitoyltransferase ZDHHC20 (EC (Zinc finger DHHC domain-containing protein 20) (DHHC-20)Zdhhc20Q5Y5T18
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC (Lysyl hydroxylase 2) (LH2)Plod2Q9R0B98
Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)P4ha1Q607158
Properdin (Complement factor P)Cfp PfcP116808
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC (Propanoyl-CoA:carbon dioxide ligase subunit beta)PccbQ99MN98
Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein TEMO)Psme4 Kiaa0077Q5SSW28
Proteasome assembly chaperone 1 (Down syndrome critical region protein 2 homolog)Psmg1 Dscr2Q9JK238
Proteasome subunit beta type-9 (EC (LMP-2d) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)Psmb9 Lmp2 Ring12P280768
Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer)Ago2 Eif2c2 Kiaa4215Q8CJG08
Protein C10Grcc10 C10O351278
Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein ZSIG9) (Transmembrane protein 4)Cnpy2 Msap Tmem4 Zsig9Q9QXT08
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (p140mDIA) (mDIA1)Diaph1 Diap1O088088
Protein FAM91A1Fam91a1 D15Ertd621e Kiaa0493Q3UVG38
Protein FAM98AFam98aQ3TJZ68
Protein phosphatase 2, regulatory subunit B (B56), delta isoform (Protein phosphatase 2, regulatory subunit B (B56), delta isoform, isoform CRA_b) (Protein phosphatase 2, regulatory subunit B', delta) (Protein phosphatase 2A B56delta regulatory subunit) (Putative uncharacterized protein)Ppp2r5d mCG_2696Q91V898
Protein S100-A8 (Calgranulin-A) (Chemotactic cytokine CP-10) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (Pro-inflammatory S100 cytokine) (S100 calcium-binding protein A8)S100a8 Caga Mrp8P270058
Protein S100-A9 (Calgranulin-B) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)S100a9 Cagb Mrp14P317258
Protein transport protein Sec61 subunit betaSec61bQ9CQS88
Protocadherin 1Pcdh1Q8CFX38
Putative uncharacterized protein (RIKEN cDNA 2210010C04 gene) (RIKEN cDNA 2210010C04, isoform CRA_b) (Trypsinogen 7)2210010C04Rik trypsinogen mCG_15095Q9CPN98
Putative uncharacterized protein (Syntaxin-2)Stx2 EpimQ3TJ558
Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)Pdxdc1Q99K018
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X)PdhxQ8BKZ98
Rab34 (Ras-related protein Rab-34)Rab34Q0PD208
Ran-binding protein 10 (RanBP10)Ranbp10 Kiaa1464Q6VN198
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)G3bp2P973798
Ras-related protein Rab-4ARab4a Rab4P563718
Ras-related protein Rab-6BRab6b D9Bwg0185eP612948
Ras-related protein Rab-9A (Sid 99)Rab9a Rab9 Sid99Q9R0M68
Receptor-type tyrosine-protein phosphatase (EC
Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)Rfc2Q9WUK48
Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)Rfc3Q8R3238
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)Rfc5Q9D0F68
Retrovirus-related Pol polyprotein [Includes: Reverse transcriptase (EC; Endonuclease] (Fragment)PolP104008
Rho GTPase-activating protein 17 (Neuron-associated developmentally-regulated protein) (Nadrin) (Rho-type GTPase-activating protein 17)Arhgap17Q3UIA28
Rho GTPase-activating protein 45 (Minor histocompatibility protein HA-1)Arhgap45 Hmha1Q3TBD28
Ribosome maturation protein SBDS (Protein 22A3) (Shwachman-Bodian-Diamond syndrome protein homolog)SbdsP701228
Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1-like 2)Scfd1 Stxbp1l2Q8BRF78
Secretory carrier-associated membrane protein 4 (SC4) (Secretory carrier membrane protein 4)Scamp4Q9JKV58
Sepiapterin reductase (Sepiapterin reductase, isoform CRA_b)Spr mCG_128676Q91XH58
Serine protease HTRA2, mitochondrial (EC (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)Htra2 Omi Prss25Q9JIY58
Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101)Srrm1 Pop101Q52KI88
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)Srsf6 Sfrs6 Srp55Q3TWW88
Serine/threonine-protein kinase 3 (EC (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]Stk3 Mess1 Mst2Q9JI108
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC (Protein phosphatase X) (PP-X)Ppp4c Ppp4 PpxP974708
Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)Srrt Ars2 Asr2Q99MR68
Serum amyloid P-component (SAP)Apcs Ptx2 SapP122468
SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)Sh3pxd2b Fad49 Tks4A2AAY58
SH3 domain-binding glutamic acid-rich-like proteinSh3bgrlQ9JJU88
SHC SH2 domain-binding protein 1 (Protein expressed in activated lymphocytes) (mPAL) (SHC-binding protein)Shcbp1 PalQ9Z1798
Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha)Srpra SrprQ9DBG78
Signal transducer and activator of transcription 3 (Acute-phase response factor)Stat3 AprfP422278
Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)Pds5b Aprin As3 Kiaa0979Q4VA538
Solute carrier family 12 member 2Slc12a2E9QM388
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1)Slc12a2 Nkcc1P550128
Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)Slc2a5 Glut5Q9WV388
Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) (SVCT-2) (mSVCT2) (Yolk sac permease-like molecule 2)Slc23a2 Kiaa0238 Svct2 Yspl2Q9EPR48
Sorting nexin-1Snx1Q9WV808
Sorting nexin-18 (Sorting nexin-associated Golgi protein 1)Snx18 Snag1Q91ZR28
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (mSART-3) (Tumor-rejection antigen SART3)Sart3 Kiaa0156Q9JLI88
STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM)Stambp AmshQ9CQ268
Stonin-1 (Stoned B-like factor)Ston1 Salf Sblf Stn1Q8CDJ88
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